The DOI matches its Crossref record; 201 of the 202 references it cites were found in a registry or an index.
Hsp70: Anti-apoptotic and Tumorigenic Protein
Abstract
Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is induced in response to a wide variety of physiological and environmental insults, including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Hsp70 cytoprotective properties may be explained by its anti-apoptotic function. Indeed, this protein can inhibit key effectors of the apoptotic machinery at the pre- and postmitochondrial level. In cancer cells, the expression of Hsp70 is abnormally high, and Hsp70 may participate in oncogenesis and in resistance to chemotherapy. In rodent models, Hsp70 overexpression increases tumor growth and metastatic potential. Depletion or inhibition of Hsp70 frequently reduces the size of the tumors and even can cause their complete involution. But Hsp70 can also be found in the extracellular medium. Its role is then immunogenic and the term chaperokine to define the extracellular chaperones has been advanced. Hsp70 tumorigenic functions as well as the strategies that are being developed in cancer therapy in order to inhibit Hsp70 are commented in this chapter.
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“HSP70 safeguards cellular integrity by suppressing apoptosis [65]”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [65]
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Metadata
- Authors
- Rérole, A.-L., Jego, G., & Garrido, C.
- Affiliations
- Inserm (FR)
- Corresponding author
- Garrido, Carmen
- ORCID
- Garrido, Carmen
- Venue
- Methods in Molecular Biology
- Publisher
- Humana Press
- Published
- 2011
- Volume
- 787
- Pages
- 205-230
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W7663529
- Cited by
- 118
- References
- 202
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 15 · 2015: 9 · 2014: 12 · 2013: 11 · 2012: 7
- FWCI
- 12.87
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Clusterin in disease pathology
- Keywords
- HSP70, heat shock proteins, anti-apoptotic effects, carcinogenesis, chemoresistance, metastasis, extracellular Hsp70, apoptosis, cancer therapy, Hsp70 inhibitors
- MeSH terms
- Antineoplastic Agents, Cell Differentiation, Humans, Neoplasm Metastasis, Neoplasms, Stress, Physiological, Gene Expression, Apoptosis, HSP70 Heat-Shock Proteins, Cell Proliferation, Apoptosis Regulatory Proteins, Receptors, Death Domain, Immunomodulation
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