Cited by 119Heat shock proteins researchCell death mechanisms and regulationClusterin in disease pathology

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Hsp70: Anti-apoptotic and Tumorigenic Protein

Rérole, Anne-Laure, Jego, Gaëtan, Garrido, Carmen·2011·Methods in Molecular Biology

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Abstract

Heat shock protein 70 (Hsp70) is a powerful chaperone whose expression is induced in response to a wide variety of physiological and environmental insults, including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Hsp70 cytoprotective properties may be explained by its anti-apoptotic function. Indeed, this protein can inhibit key effectors of the apoptotic machinery at the pre- and postmitochondrial level. In cancer cells, the expression of Hsp70 is abnormally high, and Hsp70 may participate in oncogenesis and in resistance to chemotherapy. In rodent models, Hsp70 overexpression increases tumor growth and metastatic potential. Depletion or inhibition of Hsp70 frequently reduces the size of the tumors and even can cause their complete involution. But Hsp70 can also be found in the extracellular medium. Its role is then immunogenic and the term chaperokine to define the extracellular chaperones has been advanced. Hsp70 tumorigenic functions as well as the strategies that are being developed in cancer therapy in order to inhibit Hsp70 are commented in this chapter.

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Authors: Rérole, A.-L., Jego, G., & Garrido, C.
Affiliations: Inserm (FR)
Corresponding author: Garrido, Carmen
ORCID: Garrido, Carmen
Venue: Methods in Molecular Biology
Publisher: Humana Press
Published: 2011
Volume: 787
Pages: 205-230
ISSN: 1064-3745 (ISSN-L)
1940-6029
DOI: 10.1007/978-1-61779-295-3_16
OpenAlex: W7663529
Cited by: 118
References: 202
Citations by year: 2025: 5 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 15 · 2015: 9 · 2014: 12 · 2013: 11 · 2012: 7
FWCI: 12.87
Type: book chapter
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Methods in molecular biology (publishedVersion)
PubMed (publishedVersion)
Funders: Ligue Contre le Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Clusterin in disease pathology
Keywords: HSP70, heat shock proteins, anti-apoptotic effects, carcinogenesis, chemoresistance, metastasis, extracellular Hsp70, apoptosis, cancer therapy, Hsp70 inhibitors
MeSH terms: Antineoplastic Agents, Cell Differentiation, Humans, Neoplasm Metastasis, Neoplasms, Stress, Physiological, Gene Expression, Apoptosis, HSP70 Heat-Shock Proteins, Cell Proliferation, Apoptosis Regulatory Proteins, Receptors, Death Domain, Immunomodulation

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Hsp70: Anti-apoptotic and Tumorigenic Protein

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