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Cited by 425

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

Neisseria meningitidis: Biology, Microbiology, and Epidemiology

Open access
Rouphael, Nadine G., Stephens, David S.·2012·Methods in Molecular Biology

Abstract

Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis and/or septicemia. In this review, we describe the biology, microbiology, and epidemiology of this exclusive human pathogen. N.meningitidis is a fastidious, encapsulated, aerobic gram-negative diplococcus. Colonies are positive by the oxidase test and most strains utilize maltose. The phenotypic classification of meningococci, based on structural differences in capsular polysaccharide, lipooligosaccharide (LOS) and outer membrane proteins, is now complemented by genome sequence typing (ST). The epidemiological profile of N. meningitidis is variable in different populations and over time and virulence of the meningococcus is based on a transformable/plastic genome and expression of certain capsular polysaccharides (serogroups A, B, C, W-135, Y and X) and non-capsular antigens. N. meningitidis colonizes mucosal surfaces using a multifactorial process involving pili, twitching motility, LOS, opacity associated, and other surface proteins. Certain clonal groups have an increased capacity to gain access to the blood, evade innate immune responses, multiply, and cause systemic disease. Although new vaccines hold great promise, meningococcal infection continues to be reported in both developed and developing countries, where universal vaccine coverage is absent and antibiotic resistance increasingly more common.

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Metadata

Authors
Rouphael, N. G., & Stephens, D. S.
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2011-09-09
Volume
799
Pages
1-20
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
OpenAlex
W1532933231
Cited by
425
References
108
FWCI
24.35
Type
book chapter
Language
en
Open access
green

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CoChat. (2026). Citation check: Neisseria meningitidis: Biology, Microbiology, and Epidemiology. https://app.cochat.ai/papers/10.1007/978-1-61779-346-2_1
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Rouphael, N. G., & Stephens, D. S. (2012). Neisseria meningitidis: Biology, Microbiology, and Epidemiology. Methods in Molecular Biology. https://doi.org/10.1007/978-1-61779-346-2_1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.