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Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences

Sievers, Fabian, Higgins, Desmond G.·2014·Methods in Molecular Biology

Abstract

Clustal Omega is a completely rewritten and revised version of the widely used Clustal series of programs for multiple sequence alignment. It can deal with very large numbers (many tens of thousands) of DNA/RNA or protein sequences due to its use of the mBED algorithm for calculating guide trees. This algorithm allows very large alignment problems to be tackled very quickly, even on personal computers. The accuracy of the program has been considerably improved over earlier Clustal programs, through the use of the HHalign method for aligning profile hidden Markov models. The program currently is used from the command line or can be run on line.

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  • Untitled work

    (2007) · doi:10.5555/1283383.1283494 · Cited by 7,364

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Metadata

Authors
Sievers, F., & Higgins, D. G.
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2013-08-23
Volume
1079
Pages
105-116
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
OpenAlex
W2189955651
Cited by
1,247
References
1
FWCI
62.40
Type
book chapter
Language
en
Open access
closed

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CoChat. (2026). Citation check: Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences. https://app.cochat.ai/papers/10.1007/978-1-62703-646-7_6
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Sievers, F., & Higgins, D. G. (2014). Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences. Methods in Molecular Biology. https://doi.org/10.1007/978-1-62703-646-7_6

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