Metabolomic Biomarkers in Mental Disorders: Bipolar Disorder and Schizophrenia
Abstract
Psychiatric disorders are some of the most impairing human diseases. Among them, bipolar disorder and schizophrenia are the most common. Both have complicated diagnostics due to their phenotypic, biological, and genetic heterogeneity, unknown etiology, and the underlying biological pathways, and molecular mechanisms are still not completely understood. Given the multifactorial complexity of these disorders, identification and implementation of metabolic biomarkers would assist in their early detection and diagnosis and facilitate disease monitoring and treatment responses. To date, numerous studies have utilized metabolomics to better understand psychiatric disorders, and findings from these studies have begun to converge. In this chapter, we briefly describe some of the metabolomic biomarkers found in these two disorders.
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The discovery of pathophysiological biomarkers in bipolar disorder may be crucial in developing novel molecular treatments.
“The discovery of pathophysiological biomarkers in BD may be crucial in developing novel molecular treatments [6].”
From Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Manic Episode Patients with Bipolar Disorder (2023) · cites this paper as [6]
Cites
Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative
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Costa, A., Riça, L., van de Bilt, M., Zandonadi, F., Gattaz, W., Talib, L., & Sussulini, A. (2023) · Metabolites · doi:10.3390/metabo13050600 · Cited by 25 · see citing works
İmre, O., & Güldeste Yılmaz, İ. V. (2023) · European Journal of Therapeutics · doi:10.58600/eurjther.20232902-1574.y · Cited by 9 · see citing works
- Authors
- Quintero, M., Stanisic, D., Cruz, G., Pontes, J. G. M., Costa, T. B. B. C., & Tasic, L.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing
- Published
- 2019
- Volume
- 1118
- Pages
- 271-293
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2911432352
- Cited by
- 32
- References
- 4
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2
- FWCI
- 3.42
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- metabolomic biomarkers, bipolar disorder, schizophrenia, mental illness, early diagnosis, disease surveillance, treatment response, metabolic pathways
- MeSH terms
- Bipolar Disorder, Humans, Schizophrenia, Biomarkers, Metabolomics
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