Schizophrenia
Open accessAbstract
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous--but so are the challenges.
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Abnormal neuronal function in schizophrenia is not confined to a small number of brain structures, which might explain its diverse psychopathology, broad cognitive impairments, and lack of regional specificity in neuroimaging.
“This suggests that abnormal neuronal function in schizophrenia is not confined to a small number of brain structures, which in turn might explain its diverse psychopathology, association with a broad range of cognitive impairments, and lack of regional specificity in neuroimaging measures1.”
From Mapping genomic loci implicates genes and synaptic biology in schizophrenia (2022) · cites this paper as [1]
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- Authors
- Owen, M. J., Sawa, A., & Mortensen, P. B.
- Affiliations
- Cardiff University (GB)
- Johns Hopkins University (US)
- Aarhus University (DK)
- Corresponding author
- Owen, Michael J
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 388
- Issue
- 10039
- Pages
- 86-97
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC4940219
- OpenAlex
- W4211145950
- Cited by
- 1,870
- References
- 141
- Citations by year
- 2026: 182 · 2025: 188 · 2024: 214 · 2023: 198 · 2022: 259 · 2021: 226 · 2020: 173 · 2019: 143 · 2018: 152 · 2017: 97 · 2016: 37
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Wellcome Trust
- Lundbeckfonden (R155-2014-1724)
- Medical Research Council (MR/L010305/1)
- National Institute of Mental Health (R21MH085226, MH‐105660, MH084018, MH085226, RC1MH088753, MH 092443, MH‑088753, P20MH084018, R01MH069853, R01MH105660, MH-094268, P50MH094268, MH069853, R01MH092443)
- National Institute on Drug Abuse (DA-040127, R21DA040127)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, brain development, genetic factors, environmental factors, dopamine signaling, psychotic symptoms, synaptic dysfunction, neuronal connectivity, interneurons, antipsychotic drugs, psychotherapy, social support, rehabilitation, genomics
- MeSH terms
- Brain, Cognition Disorders, Environmental Exposure, Humans, Psychotherapy, Schizophrenia, Schizophrenic Psychology, Social Support, Social Work, Antipsychotic Agents
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