Cited by 1,870Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

Schizophrenia

Open access
Owen, Michael J, Sawa, Akira, Mortensen, Preben B·2016·The Lancet

Abstract

Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous--but so are the challenges.

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Crossref · 10.1016/s0140-6736(15)01121-6

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  • Abnormal neuronal function in schizophrenia is not confined to a small number of brain structures, which might explain its diverse psychopathology, broad cognitive impairments, and lack of regional specificity in neuroimaging.

    “This suggests that abnormal neuronal function in schizophrenia is not confined to a small number of brain structures, which in turn might explain its diverse psychopathology, association with a broad range of cognitive impairments, and lack of regional specificity in neuroimaging measures1.”

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Research works printed but not linked: 5

  1. [11]American Psychological Association Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition: DSM-5 2013 Arlington, VA American Psychiatric Association
  2. [37]Craddock N Owen MJ The Kraepelinian dichotomy – going, going… but still not gone Br J Psychiatry 2010 196 92 95 20118450 PMC2815936
  3. [75]Kirov G Rees E Walters JTR The penetrance of copy number variations for schizophrenia and developmental delay Biological psychiatry 2014 75 5 378 385 23992924 PMC4229045
  4. [99]Hall J Trent S Thomas KL O'Donovan MC Owen MJ Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity Biological psychiatry 2015 77 1 52 58 25152434
  5. [134]van Os J Kenis G Rutten BP The environment and schizophrenia Nature 2010 468 7321 203 212 21068828

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Authors
Owen, M. J., Sawa, A., & Mortensen, P. B.
Affiliations
  • Cardiff University (GB)
  • Johns Hopkins University (US)
  • Aarhus University (DK)
Corresponding author
Owen, Michael J
Venue
The Lancet
Publisher
Elsevier BV
Published
2016-07
Volume
388
Issue
10039
Pages
86-97
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W4211145950
Cited by
1,870
References
141
Citations by year
2026: 182 · 2025: 188 · 2024: 214 · 2023: 198 · 2022: 259 · 2021: 226 · 2020: 173 · 2019: 143 · 2018: 152 · 2017: 97 · 2016: 37
FWCI
20.55
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Wellcome Trust
  • Lundbeckfonden (R155-2014-1724)
  • Medical Research Council (MR/L010305/1)
  • National Institute of Mental Health (R21MH085226, MH‐105660, MH084018, MH085226, RC1MH088753, MH 092443, MH‑088753, P20MH084018, R01MH069853, R01MH105660, MH-094268, P50MH094268, MH069853, R01MH092443)
  • National Institute on Drug Abuse (DA-040127, R21DA040127)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
schizophrenia, brain development, genetic factors, environmental factors, dopamine signaling, psychotic symptoms, synaptic dysfunction, neuronal connectivity, interneurons, antipsychotic drugs, psychotherapy, social support, rehabilitation, genomics
MeSH terms
Brain, Cognition Disorders, Environmental Exposure, Humans, Psychotherapy, Schizophrenia, Schizophrenic Psychology, Social Support, Social Work, Antipsychotic Agents

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