The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Optical Coherence Tomography (OCT): Principle and Technical Realization
Open accessAbstract
Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional tissue imaging. It typically uses light in the near-infrared spectral range which has a penetration depth of several hundred microns in tissue. The backscattered light is measured with an interferometric set-up to reconstruct the depth profile of the sample at the selected location. A scanning OCT beam allows for acquisition of cross-sectional images of the tissue structure. Different technical methods are introduced and compared regarding their properties like sensitivity, imaging speed and penetration depth. Regardless of the technical realization, axial resolution and imaging range of an OCT system are determined by light source and detector characteristics. Combining retinal OCT with a confocal scanning laser ophthalmoscope allows for motion tracking during acquisition and to examine the exact same position at any time again. Segmentation of features is the basis for automatic depth measurements and standardized measurements to be compared with normative databases. New trends show the ability of functional OCT to image flow, polarizing properties of tissue and even mechanical properties like elasticity. Recent approaches to improve the resolution and the acquisition speed show the ongoing research interest in OCT.
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“OCT imaging at depth is negatively affected by absorption with light absorption and attenuation in upper tissue layers leading to less light reaching lower layers.”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [85]
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Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K. W., Puliafito, C. A., et al. (1991) · Science · doi:10.1126/science.1957169 · Cited by 14,001
Optical coherence tomography - principles and applications
FERCHER, A. F., Drexler, W., Hitzenberger, C. K. F., & Lasser, T. (2003) · Reports on Progress in Physics · doi:10.1088/0034-4885/66/2/204 · Cited by 1,871
Performance of fourier domain vs time domain optical coherence tomography
Leitgeb, R. A., Hitzenberger, C. K. F., & FERCHER, A. F. (2003) · Optics Express · doi:10.1364/oe.11.000889 · Cited by 1,859
Sensitivity advantage of swept source and Fourier domain optical coherence tomography
Choma, M. A., Šarunic, M. V., Yang, C., & Izatt, J. A. (2003) · Optics Express · doi:10.1364/oe.11.002183 · Cited by 1,789
de Boer, J. F., Cense, B., Park, B. H., Pierce, M. C., Tearney, G. J., & Bouma, B. E. (2003) · Optics Letters · doi:10.1364/ol.28.002067 · Cited by 1,245
Measurement of intraocular distances by backscattering spectral interferometry
FERCHER, A. F., Hitzenberger, C. K. F., Kamp, G., & El-Zaiat, S. Y. (1995) · Optics Communications · doi:10.1016/0030-4018(95)00119-s · Cited by 1,208
von Braunmühl, T. (2015) · Der Hautarzt · doi:10.1007/s00105-015-3607-z · Cited by 1,036
Huber, R. A., Wojtkowski, M., & Fujimoto, J. G. (2006) · Optics Express · doi:10.1364/oe.14.003225 · Cited by 982
Refractive indices of water and ice in the 065- to 25-μm spectral range
Kou, L., Labrie, D., & Chýlek, P. (1993) · Applied Optics · doi:10.1364/ao.32.003531 · Cited by 804
Optical coherence tomography using a frequency-tunable optical source
Chinn, S. R., Swanson, E. A., & Fujimoto, J. G. (1997) · Optics Letters · doi:10.1364/ol.22.000340 · Cited by 666
The Development, Commercialization, and Impact of Optical Coherence Tomography
Fujimoto, J. G., & Swanson, E. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19963 · Cited by 477
Optical coherence tomography today: speed, contrast, and multimodality
Drexler, W., Liu, M., Kumar, A., Kamali, T., Unterhuber, A., & Leitgeb, R. A. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.7.071412 · Cited by 475
Polarization sensitive optical coherence tomography – a review [Invited]
de Boer, J. F., Hitzenberger, C. K. F., & Yasuno, Y. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.001838 · Cited by 463
Wolf, S., Ćeklić, L., Brinkmann, C. K., Iliev, M. E., Frey, M., Rothenbuehler, S. P., Enzmann, V., & Wolf, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2970 · Cited by 426
Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography
Götzinger, E., Pircher, M., Geitzenauer, W., Ahlers, C., Baumann, B., Michels, S., Schmidt-Erfurth, U. M., & Hitzenberger, C. K. F. (2008) · Optics Express · doi:10.1364/oe.16.016410 · Cited by 293
Optical coherence elastography in ophthalmology
Kirby, M. A., Pelivanov, I., Song, S., Ambroziński, Ł., Yoon, S. J., Gao, L., Li, D. S., Shen, T. T., Wang, R. K., & O’Donnell, M. (2017) · Journal of Biomedical Optics · doi:10.1117/1.jbo.22.12.121720 · Cited by 232
In vivo optical imaging of physiological responses to photostimulation in human photoreceptors
Hillmann, D., Spahr, H., Pfäffle, C., Sudkamp, H. M., Franke, G. L., & Hüttmann, G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606428113 · Cited by 227
In vivo Brillouin optical microscopy of the human eye
Scarcelli, G., & Yun, S. H. (2012) · Optics Express · doi:10.1364/oe.20.009197 · Cited by 216
A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity
Wang, S., Larin, K. V., Li, J., Vantipalli, S., Manapuram, R. K., Aglyamov, S. R., Emelianov, S., & Twa, M. D. (2013) · Laser Physics Letters · doi:10.1088/1612-2011/10/7/075605 · Cited by 182
Wavelength-tuning interferometry of intraocular distances
Lexer, F., Hitzenberger, C. K. F., FERCHER, A. F., & Kulhavy, M. (1997) · Applied Optics · doi:10.1364/ao.36.006548 · Cited by 181
Yi, J., Liu, W., Chen, S., Backman, V., Sheibani, N., Sorenson, C. M., Fawzi, A. A., Linsenmeier, R. A., & Zhang, H. F. (2015) · Light Science & Applications · doi:10.1038/lsa.2015.107 · Cited by 173
Aberration-free volumetric high-speed imaging of in vivo retina
Hillmann, D., Spahr, H., Hain, C., Sudkamp, H. M., Franke, G. L., Pfäffle, C., Winter, C., & Hüttmann, G. (2016) · Scientific Reports · doi:10.1038/srep35209 · Cited by 160
Fernández, E. J. M., Hermann, B. M., Považay, B., Unterhuber, A., Sattmann, H., Höfer, B., Ahnelt, P. K., & Drexler, W. (2008) · Optics Express · doi:10.1364/oe.16.011083 · Cited by 156
Drexler, W. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374203-2.00247-5 · Cited by 142
Biological and medical physics, biomedical engineering
Herman, I. P. (2014) · Cited by 136
Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity
Ambroziński, Ł., Song, S., Yoon, S. J., Pelivanov, I., Li, D. S., Gao, L., Shen, T. T., Wang, R. K., & O’Donnell, M. (2016) · Scientific Reports · doi:10.1038/srep38967 · Cited by 134
Spaide, R. F., Akïba, M., & Ohno‐Matsui, K. (2012) · Retina · doi:10.1097/iae.0b013e318242b9c0 · Cited by 127
Subaperture correlation based digital adaptive optics for full field optical coherence tomography
Kumar, A., Drexler, W., & Leitgeb, R. A. (2013) · Optics Express · doi:10.1364/oe.21.010850 · Cited by 126
Photoreceptor disc shedding in the living human eye
Kocaoglu, O. P., Liu, Z., Zhang, F., Kurokawa, K., Jonnal, R. S., & Miller, D. T. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.004554 · Cited by 97
Zawadzki, R. J., Jones, S. M., Pilli, S., Balderas-Mata, S. E., Kim, D. Y., Olivier, S. S., & Werner, J. S. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.001674 · Cited by 90
Nakamura, Y., Makita, S., Yamanari, M., Itoh, M., Yatagai, T., & Yasuno, Y. (2007) · Optics Express · doi:10.1364/oe.15.007103 · Cited by 89
Braaf, B., Vermeer, K. A., de Groot, M., Vienola, K. V., & de Boer, J. F. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.002736 · Cited by 87
Roy, A. S., Kurian, M., Matalia, H. P., & Shetty, R. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.04.010 · Cited by 87
Miura, M., Makita, S., Sugiyama, S., Hong, Y.-J., Yasuno, Y., Elsner, A. E., Tamiya, S., Tsukahara, R., Iwasaki, T., & Goto, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-03529-8 · Cited by 85
Line-field parallel swept source MHz OCT for structural and functional retinal imaging
Fechtig, D. J., Grajciar, B., Schmoll, T., Blatter, C., Werkmeister, R. M., Drexler, W., & Leitgeb, R. A. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.000716 · Cited by 81
Salas, M., Augustin, M., Ginner, L., Kumar, A., Baumann, B., Leitgeb, R. A., Drexler, W., Prager, S. G., Häfner, J., Schmidt-Erfurth, U. M., et al. (2016) · Biomedical Optics Express · doi:10.1364/boe.8.000207 · Cited by 80
Computational optical coherence tomography [Invited]
Liu, Y.-Z., South, F. A., Xu, Y., Carney, P. S., & Boppart, S. A. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.001549 · Cited by 58
Lawman, S., Dong, Y., Williams, B. M., Romano, V., Kaye, S. B., Harding, S. P., Willoughby, C. E., Shen, Y., & Zheng, Y. (2016) · Optics Express · doi:10.1364/oe.24.012395 · Cited by 44
Schütze, C., Bolz, M., Sayegh, R. G., Baumann, B., Pircher, M., Götzinger, E., Hitzenberger, C. K. F., & Schmidt-Erfurth, U. M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7877 · Cited by 34
Off-axis reference beam for full-field swept-source OCT and holoscopy
Hillmann, D., Spahr, H., Sudkamp, H. M., Hain, C., Hinkel, L., Franke, G. L., & Hüttmann, G. (2017) · Optics Express · doi:10.1364/oe.25.027770 · Cited by 34
Go¨tzinger, E., Pircher, M., Baumann, B., Hirn, C., Vass, C., & Hitzenberger, C. K. F. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2081 · Cited by 29
Nafar, Z., Jiang, M.-S., Wen, R., & Jiao, S.-L. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.003220 · Cited by 23
Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second
Klein, T., Wieser, W., André, R., Pfeiffer, T., Eigenwillig, C. M., & Huber, R. A. (2012) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.908798 · Cited by 20
Optical Coherence Elastography
Kennedy, B. F., Kennedy, K. M., Oldenburg, A. L., Adie, S. G., Boppart, S. A., & Sampson, D. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_33 · Cited by 19
Optical Microangiography Based on Optical Coherence Tomography
Reif, R., & Wang, R. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_45 · Cited by 2
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Wave-based optical coherence elastography: the 10-year perspective
Zvietcovich, F., & Larin, K. V. (2021) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac4512 · Cited by 127
Anatomical structures, cell types and biomarkers of the Human Reference Atlas
Börner, K., Teichmann, S. A., Quardokus, E. M., Gee, J. C., Browne, K., Osumi-Sutherland, D., Herr, B. W., Bueckle, A., Paul, H., Haniffa, M. A., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00788-6 · Cited by 123
Towards a better understanding of annotation tools for medical imaging: a survey
Aljabri, M., Alamir, M., Alghamdi, M., Abdel-Mottaleb, M. S., & Collado‐Mesa, F. (2022) · Multimedia Tools and Applications · doi:10.1007/s11042-022-12100-1 · Cited by 111
Oculomics: Current concepts and evidence
Zhu, Z., Wang, Y., Qi, Z., Hu, W., Zhang, X., Wagner, S. K., Wang, Y., Ran, A. R., Ong, J., Waisberg, E., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101350 · Cited by 97
Imaging of Uveal Melanoma—Current Standard and Methods in Development
Solnik, M., Paduszyńska, N., Czarnecka, A. M., Synoradzki, K. J., Yousef, Y. A., Chorągiewicz, T., Ręjdak, R., Toro, M. D., Zweifel, S. A., Dyndor, K., et al. (2022) · Cancers · doi:10.3390/cancers14133147 · Cited by 92
Metadata
- Authors
- Aumann, S., Donner, S., Fischer, J., & Müller, F.
- Affiliations
- Heidelberg Engineering (Germany) (DE)
- Venue
- High Resolution Imaging in Microscopy and Ophthalmology
- Publisher
- Springer International Publishing
- Published
- 2019
- Pages
- 59-85
- OpenAlex
- W2967073593
- Cited by
- 449
- References
- 46
- Citations by year
- 2026: 41 · 2025: 112 · 2024: 109 · 2023: 71 · 2022: 70 · 2021: 31 · 2020: 15
- FWCI
- 44.32
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Springer eBooks (publishedVersion, cc-by)
- Funders
- Heidelberg Engineering GmbH
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Adaptive optics and wavefront sensing
- Keywords
- optical coherence tomography, retinal imaging, near-infrared light, interferometry, axial resolution, penetration depth, confocal scanning laser ophthalmoscope, motion tracking, image segmentation, depth measurement, tissue elasticity imaging, imaging speed
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