The DOI matches its Crossref record; 501 of the 501 references it cites were found in a registry or an index.
Inhibition of Cytochrome P450 Enzymes
Open accessAbstract
Cytochrome P450s (P450s) are subject to inhibition/inactivation by various chemically diverse agents, which may interact directly or indirectly with either the P450 prosthetic heme or the protein moiety or with both moieties. This inhibition is clinically relevant, as it can block physiological pathways as well as result in therapeutically significant beneficial or adverse effects and clinically relevant drug–drug interactions. Herein, we discuss the various chemical agents and their chemical mechanisms that lead to such reversible, quasi-irreversible, or irreversible inhibition of these enzymes. We note that such inhibition targeted at P450-dependent physiological and/or pathological processes has been ingeniously and effectively harnessed not only in the design and development of clinically relevant therapeutic agents but also of fungicides, insecticides, and herbicides.
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Feyereisen, R. (2005) · Comprehensive Molecular Insect Science · doi:10.1016/b0-44-451924-6/00049-1 · Cited by 420
Shafiei, M., Peyton, L., Hashemzadeh, M., & Foroumadi, A. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104240 · Cited by 295
Chatterjee, P., & Franklin, M. R. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.11.1391 · Cited by 146
Hamamura, N., Page, C., Long, T., Semprini, L., & Arp, D. J. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.9.3607-3613.1997 · Cited by 80
Metadata
- Authors
- Correia, M. A., & Hollenberg, P. F.
- Venue
- Cytochrome P450
- Publisher
- Springer International Publishing
- Published
- 2015
- Pages
- 177-259
- OpenAlex
- W2155231169
- Cited by
- 257
- References
- 501
- FWCI
- 69.64
- Type
- book chapter
- Language
- en
- Open access
- hybrid
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