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Cited by 65Glycogen Storage Diseases and MyoclonusMetabolism, Diabetes, and CancerEstrogen and related hormone effects

Glucocorticoids and hepatic glycogen metabolism.

Stalmans, W., Laloux, M.·1979·Monographs on endocrinology
DOI 10.1007/978-3-642-81265-1_27
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Abstract

The steady accumulation of glycogen in fetal rat liver during the last fifth of gestation is elicited by a transient rise in the level of circulating corticosterone. One effect of glucocorticoids is to induce glycogen synthase. The actual deposition of glycogen, however, depends on the appearance of a small amount of glycogen synthase in the active, dephosphorylated form. Induction of glycogen synthase phosphatase by glucocorticoids may explain the latter crucial process. Insulin enhances further the rate of glycogen deposition. The effect of insulin requires a previous exposure of the fetal liver to glucocorticoids. It is exerted on the enzyme interconversion system and appears not to involve new protein synthesis. Administration of glucocorticoids to adult fed or fasted animals causes within 3 h an intensive deposition of glycogen in the liver. This phenomenon is ultimately explained by both an activation of glycogen synthase and an inactivation of glycogen phosphorylase. The latter process may be due to an enhanced activity of phosphorylase phosphatase, or possibly of phosphorylase kinase phosphatase. The activation of glycogen synthase is explained by an enhanced activity of glycogen synthase phosphatase. The latter enzyme is normally profoundly inhibited by phosphorylase a; glucocorticoids cause the appearance in the liver of a protein factor that decreases and eventually cancels this inhibitory effect of phosphorylase a. It remains to be established whether or not some part of the glucocorticoid effect on adult liver is mediated by insulin.

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Authors
Stalmans, W., & Laloux, M.
Venue
Monographs on endocrinology
Publisher
Springer Berlin Heidelberg
Published
1979
Volume
12
Pages
517-533
ISSN
0077-1015 (ISSN-L)
DOI
10.1007/978-3-642-81265-1_27
OpenAlex
W181382045
Cited by
65
References
78
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 4 · 2019: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2
FWCI
8.07
Type
book chapter
Language
en
Open access
closed
Locations
  • Monographs on endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
glucocorticoids, hepatic glycogen metabolism, glycogen synthase, glycogen synthase phosphatase, glycogen phosphorylase, phosphorylase a, insulin, corticosterone, enzyme dephosphorylation
MeSH terms
Animals, Female, Fetus, Glucocorticoids, Phosphorylases, Glycogen Synthase, Glycogen-Synthase-D Phosphatase, Hydrocortisone, Insulin, Kinetics, Liver, Liver Glycogen, Pregnancy, Protein Kinases, Rats

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