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Cited by 130Metabolism, Diabetes, and CancerEstrogen and related hormone effectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Regulation of gluconeogenesis by glucocorticoids.

Exton, J. H.·1979·Monographs on endocrinology
DOI 10.1007/978-3-642-81265-1_28
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Abstract

1. Regulation of gluconeogenic substrate supply and modulation of the gluconeogenic pathway in the liver are both important in the control of gluconeogenesis by glucocorticoids. 2. Adrenal deficiency decreases the release of gluconeogenic and other amino acids from skeletal muscle during starvation. The effect is reversed by glucocorticoid replacement. The changes in amino acid release are accompanied by similar alterations in tissue amino acid levels and are not explained by alterations in net protein breakdown. Glucocorticoids do not alter protein catabolism and cause a small inhibition of protein synthesis. The biochemical alterations underlying the changes in amino acid metabolism induced by these steroids remain to be elucidated. Glucocorticoids may also regulate the supply of gluconeogenic substrates through permissive effects on the lipolytic action of catecholamines and other hormones in adipose tissue and on the glycogenolytic action of catecholamines on skeletal muscle. 3. Glucocorticoids are required for the increases in gluconeogenesis in starvation and diabetes. Part of their action is exerted directly on the liver and appears to involve modulation of P-enlopyruvate carboxykinase levels. Glucocorticoids increase the synthesis of this enzyme apparently through effects at the level of transcription. 4. Glucocorticoids exert permissive effects on the stimulation of gluconeogenesis in the liver by glucagon and epinephrine. The steroids are not required for cAMP generation or protein kinase activation by these hormones, but appear to act by maintaining the responsiveness of certain enzymes to the effects of the cAMP and alpha-adrenergic systems. It is proposed that this involves the maintenance of a normal intracellular ionic environment.

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Research works printed but not linked: 6

  1. Steele, R.: Influences of corticosteroids on protein and carbohydrate metabolism. In: Handbook of Physiology. Sect. 7: Endrocrinology, Vol. VI. Adrenal Gland. Blaschko, H., Sayers, G., Smith, A. D. (eds.), Washington, D. C.: American Physiological Society 1975, pp. 135–167.
  2. Caldwell, M. D., Lacy, W. W., Exton, J. H.: Effect of glucocorticoids on substrate utilization by muscle. Fed. Proc. 36, 527 (1977).
  3. Rannels, S. R., Li J. B., Jefferson, L. S.: Amino and release and protein turnover in perfused skeletal muscle of fasted normal and adrenalectomized rats. Diabetes 25, 333 (1976).
  4. Fain, J. N., Czech, M. P.: Glucocorticoid effects on lipid mobilization and adipose tissue metabolism. In: Handbook of Physiology. Section 7: Endocrinology, Vol. VI. Adrenal Gland. Blaschko, H., Sayers, G., Smith, A. D. (eds.) Washington, D. C.: American Physiological Society 1975, pp. 169–178.
  5. Chan, T. M.: Unpublished observations (1977).
  6. Chan, T. M., Exton, J. H.: Enhanced β-adrenergic activation of glycogen Phosphorylase in hepatocytes from adrenalectomized rats. Fed. Proc. 36, 384 (1977).

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Metadata

Authors
Exton, J. H.
Corresponding author
Exton, J. H.
Venue
Monographs on endocrinology
Publisher
Springer Berlin Heidelberg
Published
1979
Volume
12
Pages
535-546
ISSN
0077-1015 (ISSN-L)
DOI
10.1007/978-3-642-81265-1_28
OpenAlex
W2407810808
Cited by
130
References
46
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 4
FWCI
2.39
Type
book chapter
Language
en
Open access
closed
Locations
  • Monographs on endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
gluconeogenesis, glucocorticoids, starvation, adrenal insufficiency, glucocorticoid replacement therapy, protein synthesis, lipolysis, catecholamines, glycogenolysis, transcriptional regulation, glucagon, epinephrine, cAMP signaling, alpha-adrenergic receptors, diabetes mellitus
MeSH terms
Adrenalectomy, Animals, Diabetes Mellitus, Experimental, Epinephrine, Glucagon, Glucocorticoids, Gluconeogenesis, Hydrocortisone, Liver, Rats

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