Textbook of Aging Skin
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GHK suppresses production of Interleukin-6, a main positive regulator of fibrinogen production, both in cell cultures and in mice.
“As mentioned above (Park et al.), GHK suppresses the production of Interleukin-6, a main positive regulator of fibrinogen production, both in cell cultures and in mice.”
From Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data (2018) · cites this paper as [44]
Because equal amounts of all three polypeptide chains are needed to produce fibrinogen, suppression of synthesis of one chain will have a general inhibitory effect on fibrinogen synthesis.
“Since equal amounts of all three polypeptide chains are needed to produce fibrinogen, when synthesis of one of the chain of fibrinogen is suppressed, it will have a general inhibitory effect on fibrinogen synthesis [44].”
From Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data (2018) · cites this paper as [44]
The authors' gene profiling data indicate that GHK downregulates the gene for the beta chain of fibrinogen by 475%.
“As our gene profiling data indicate, GHK downregulates (−475%) the gene for the beta chain of fibrinogen.”
From Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data (2018) · cites this paper as [44]
GHK restores function of damaged fibroblasts.
“Early research showed that GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin, accelerates wound healing, restores function of damaged fibroblasts, reduces scarring, and improves regeneration of skin, stomach, and intestinal linings.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK is naturally present in human blood and declines with age.
“GHK, which is naturally present in human blood, declines with age.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK accelerates wound healing.
“Early research showed that GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin, accelerates wound healing, restores function of damaged fibroblasts, reduces scarring, and improves regeneration of skin, stomach, and intestinal linings.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin.
“Early research showed that GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin, accelerates wound healing, restores function of damaged fibroblasts, reduces scarring, and improves regeneration of skin, stomach, and intestinal linings.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK reduces scarring.
“Early research showed that GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin, accelerates wound healing, restores function of damaged fibroblasts, reduces scarring, and improves regeneration of skin, stomach, and intestinal linings.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK stimulates hair growth and improves outcomes in hair grafting.
“GHK stimulates hair growth and is used to improve outcomes in hair grafting [7].”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
GHK improves regeneration of skin, stomach, and intestinal linings.
“Early research showed that GHK stimulates synthesis of collagen, elastin, and glycosaminoglycans in skin, accelerates wound healing, restores function of damaged fibroblasts, reduces scarring, and improves regeneration of skin, stomach, and intestinal linings.”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [7]
Cites
The Procter and Gamble Company
(1925) · Industrial & Engineering Chemistry · doi:10.1021/ie50188a048 · Cited by 9 · see citing works
Biology of Stratum Corneum: Tape Stripping and Protein Quantification
Alikhan, A., & Maïbach, H. I. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_40 · Cited by 8 · see citing works
Tsuchida, K., & Yamada, H. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_119-1 · Cited by 5 · see citing works
Torres, S. M., Hughes, C. R., & Berwick, M. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_57-2 · Cited by 2 · see citing works
Assessing Quality of Ordinal Scales Depicting Skin Aging Severity
Valet, F., Ezzedine, K., Malvy, D. J.-M., Mary, J., & Guinot, C. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_87-2 · Cited by 2 · see citing works
Cutaneous Responses to Tropospheric Ozone Exposure
Valacchi, G. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_41 · Cited by 2 · see citing works
Cosmetic Surgery in the Elderly
(2012) · SpringerReference · doi:10.1007/springerreference_168465 · Cited by 2 · see citing works
Elderly Face No Added Risk from Cosmetic Surgery
Winocour, J. S., Gupta, V., Higdon, K. K., et al. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_148-1 · Cited by 1 · see citing works
Κατσαρού, Α., Armenaka, M. C., Zafiriou, E., et al. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_62-2 · Cited by 1 · see citing works
Susceptibility to Irritation in the Elderly
Farage, M. A., Miller, K. W., Gerberick, G. F., Ryan, C. A., & Maïbach, H. I. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_80 · Cited by 1 · see citing works
Self-citationInfluence of Exogenous Factors on Skin Aging
Ahuja, A., Singh, N., Gupta, P., Mishra, S., & Rani, V. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_173-1 · Cited by 1 · see citing works
Cellular Energy Metabolism and Oxidative Stress
Cheng, S., Hourigan, R., Nabi, Z. F., & Du‐Thumm, L. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_30 · Cited by 1 · see citing works
Farage, M. A., Miller, K. W., & Ledger, W. J. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_103 · Cited by 1 · see citing works
Self-citation
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Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Pickart, L., & Margolina, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071987 · Cited by 158 · see citing works
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works
Skin Regenerative and Anti-Cancer Actions of Copper Peptides
Pickart, L., & Margolina, A. (2018) · Cosmetics · doi:10.3390/cosmetics5020029 · Cited by 33 · see citing works
- Authors
- Maibach, H. I., Miller, K. W., & Farage, M. A.
- Affiliations
- Procter & Gamble (United States) (US)
- University of California, San Francisco (US)
- Venue
- Springer eBooks
- Publisher
- Springer Berlin Heidelberg
- Published
- 2017
- OpenAlex
- W4247218755
- Cited by
- 51
- References
- 13
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5
- Type
- reference entry
- Language
- en
- Open access
- closed
- Licence
- Locations
- Springer eBooks (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- skin aging, age-related diseases, skin physiology, genomics, cosmetic ingredients, geriatric dermatology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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