Cholinergic and peptidergic systems in PSP
Abstract
PSP is associated with a widespread cholinergic deficit likely corresponding to a loss in cholinergic neurons. The cholinergic damage dramatically affects the basal ganglia and specific cell groups of the mesencephalon and pons. This provides an anatomically defined basis for motor and supranuclear oculomotor syndromes characteristic of PSP. Unlike Alzheimer's disease and Parkinson's disease with dementia, the disease is not associated with a marked cholinergic deficiency in the cerebral cortex. Various peptides are present at normal concentrations in extrapyramidal and limbic subcortical areas in brains of patients with PSP. Of particular interest, is somatostatin, the levels of which are subnormal in cerebral cortex of patients with dementia of Alzheimer' or Parkinson's disease type.
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PSP is associated with a widespread cholinergic deficit resulting from a loss of cholinergic neurons, and with an obvious cholinergic deficiency in the cerebral cortex.
“Meanwhile, PSP is associated with a widespread cholinergic deficit resulting from a loss of cholinergic neurons, and with an obvious cholinergic deficiency in the cerebral cortex [52].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [52]
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Progressive Supranuclear Palsy: Pathology and Genetics
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- Authors
- Javoy-Agid, F.
- Affiliations
- Inserm (FR)
- Corresponding author
- Javoy-Agid, F.
- Venue
- Journal of Neural Transmission. Supplementa
- Publisher
- Springer Vienna
- Published
- 1994
- Volume
- 42
- Pages
- 205-218
- ISSN
- 0303-6995 (ISSN-L)
- OpenAlex
- W39790970
- Cited by
- 23
- References
- 50
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Journal of neural transmission. Supplementum (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- progressive supranuclear palsy, cholinergic deficit, cholinergic neurons, peptidergic systems, somatostatin, basal ganglia, midbrain, passive optical networks, extrapyramidal system, limbic system, Alzheimer's disease, Parkinson's disease, dementia
- MeSH terms
- Acetylcholine, Humans, Neurons, Neuropeptides, Supranuclear Palsy, Progressive
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