Control of Iron Metabolism in Bacteria
Abstract
Bacteria depend upon iron as a vital cofactor that enables a wide range of key metabolic activities. Bacteria must therefore ensure a balanced supply of this essential metal. To do so, they invest considerable resourse into its acquisition and employ elaborate control mechanisms to eleviate both iron-induced toxitiy as well as iron deficiency. This chapter describes the processes that bacteria engage in maintaining iron homeostasis. The focus is Escherichia coli, as this bacterium provides a well studied example. A summary of the current status of understanding of iron management at the 'omics' level is also presented.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Enterobacteriacae use other siderophores such as aerobactin, but can also directly ingest heme and ionic iron.
“However, enterobacteriacae use other siderophores such as aerobactin, but can also directly ingest heme and ionic iron (Andrews et al., 2013;Hantke, 2001).”
From Iron in infection and immunity (2020) · cites this paper as Andrews et al., 2013
Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works
Siderophore-Mediated Iron Transport: Crystal Structure of FhuA with Bound Lipopolysaccharide
Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., & Welte, W. (1998) · Science · doi:10.1126/science.282.5397.2215 · Cited by 787 · see citing works
Iron and metal regulation in bacteria
Hantke, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00184-3 · Cited by 755 · see citing works
Passage of Heme-Iron Across the Envelope of <i>Staphylococcus aureus</i>
Mazmanian, S. K., Skaar, E. P., Gaspar, A. H., Humayun, M., Gornicki, P., Jelenska, J., Joachmiak, A., Missiakas, D. M., & Schneewind, O. (2003) · Science · doi:10.1126/science.1081147 · Cited by 593 · see citing works
Lack of a role for iron in the Lyme disease pathogen
Posey, J. E., & Gherardini, F. C. (2000) · Science · doi:10.1126/science.288.5471.1651 · Cited by 538 · see citing works
Functional specialization within the Fur family of metalloregulators
Lee, J.-W., & Helmann, J. D. (2007) · BioMetals · doi:10.1007/s10534-006-9070-7 · Cited by 432 · see citing works
<i>Staphylococcus aureus</i> IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization
Torres, V. J., Pishchany, G., Humayun, M., Schneewind, O., & Skaar, E. P. (2006) · Journal of Bacteriology · doi:10.1128/jb.01335-06 · Cited by 302 · see citing works
Recognition of DNA by Fur: a Reinterpretation of the Fur Box Consensus Sequence
Baichoo, N., & Helmann, J. D. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.21.5826-5832.2002 · Cited by 282 · see citing works
Structural basis for iron piracy by pathogenic Neisseria
Noinaj, N., Easley, N. C., Oke, M., Mizuno, N., Gumbart, J., Boura, E., Steere, A. N., Zak, O., Aisen, P., Tajkhorshid, E., et al. (2012) · Nature · doi:10.1038/nature10823 · Cited by 262 · see citing works
Bearden, S. W., & Perry, R. D. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01360.x · Cited by 254 · see citing works
Global analysis of the <i>Bacillus subtilis</i> Fur regulon and the iron starvation stimulon
Baichoo, N., Wang, T., Ye, R., & Helmann, J. D. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03113.x · Cited by 250 · see citing works
Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse
Tsolis, R. M., Bäumler, A. J., Heffron, F., & Stojiljkovic, I. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4549-4556.1996 · Cited by 174 · see citing works
The ferric uptake regulation (Fur) repressor is a zinc metalloprotein
Althaus, E. W., Outten, C. E., Olson, K. E., Cao, H., & O'Halloran, T. V. (1999) · Biochemistry · doi:10.1021/bi982788s · Cited by 147 · see citing works
Reduction of iron by extracellular iron reductases: implications for microbial iron acquisition
Cowart, R. E. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00012-7 · Cited by 68 · see citing works
Fournier, C., Smith, A., & Delepelaire, P. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07562.x · Cited by 67 · see citing works
Mechanism of metal ion activation of the diphtheria toxin repressor DtxR
D'Aquino, J. A., Tetenbaum-Novatt, J., White, A., Berkovitch, F., & Ringe, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500908102 · Cited by 57 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Fontenot, C. R., Tasnim, H., Valdes, K. A., Popescu, C. V., & Ding, H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014814 · Cited by 74 · see citing works
Iron acquisition and regulation systems in Streptococcus species
Ge, R., & Sun, X. (2014) · Metallomics · doi:10.1039/c4mt00011k · Cited by 48 · see citing works
- Authors
- Andrews, S., Norton, I., Salunkhe, A. S., Goodluck, H., Aly, W. S. M., Mourad-Agha, H., & Cornelis, P.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Andrews, Simon
- Venue
- Metal Ions in Life Sciences
- Publisher
- Springer Netherlands
- Published
- 2012-12-05
- Volume
- 12
- Pages
- 203-239
- ISSN
- 1559-0836 (ISSN-L)
- 1868-0402
- OpenAlex
- W2264589151
- Cited by
- 72
- References
- 16
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 14 · 2022: 11 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3
- FWCI
- 5.51
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Metal ions in life sciences (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
- Keywords
- iron metabolism, iron homeostasis, iron acquisition, iron toxicity, iron deficiency, Escherichia coli, omics
- MeSH terms
- Bacteria, Homeostasis, Iron
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
