Drosophila as a Model to Gain Insight into the Role of lncRNAs in Neurological Disorders
Abstract
It is now clear that the majority of transcription in humans results in the production of long non-protein-coding RNAs (lncRNAs) with a variable length spanning from 200 bp up to several kilobases. To date, we have a limited understanding of the lncRNA function, but a huge number of evidences have suggested that lncRNAs represent an outstanding asset for cells. In particular, temporal and spatial expression of lncRNAs appears to be important for proper neurological functioning. Stunningly, abnormal lncRNA function has been found as being critical for the onset of neurological disorders. This chapter focus on the lncRNAs with a role in diseases affecting the central nervous system with particular regard for the lncRNAs causing those neurodegenerative diseases that exhibit dementia and/or motor dysfunctions. A specific section will be dedicated to the human neuronal lncRNAs that have been modelled in Drosophila. Finally, even if only few examples have been reported so far, an overview of the Drosophila lncRNAs with neurological functions will be also included in this chapter.
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Several recent studies have indicated that lncRNAs are crucial in the development of numerous neurological disorders, including autism, schizophrenia, and depression.
“Several recent studies have indicated that lncRNAs are crucial in the development of numerous neurological disorders, including autism, schizophrenia, and depression.306–309”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [309]
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“306 – 309 However, further research is needed to determine their signal pathway targets and regulation.”
Background
- Authors
- Lo Piccolo, L.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Singapore
- Published
- 2018
- Volume
- 1076
- Pages
- 119-146
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2810514519
- Cited by
- 13
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 2
- FWCI
- 1.90
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- long non-coding RNA, lncRNA function, neurological disorders, neurodegenerative diseases, Drosophila model, dementia, motor impairment, central nervous system
- MeSH terms
- Animals, Disease Models, Animal, Drosophila melanogaster, Humans, Neurodegenerative Diseases, RNA, Long Noncoding
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