In Vivo Evaluation of the Biocompatibility of Biomaterial Device
Abstract
Biomaterials are widely used to produce devices for regenerative medicine. After its implantation, an interaction between the host immune system and the implanted biomaterial occurs, leading to biomaterial-specific cellular and tissue responses. These responses may include inflammatory, wound healing responses, immunological and foreign-body reactions, and even fibrous encapsulation of the implanted biomaterial device. In fact, the cellular and molecular events that regulate the success of the implant and tissue regeneration are played at the interface between the foreign body and the host inflammation, determined by innate and adaptive immune responses. This chapter focuses on host responses that must be taken into consideration in determining the biocompatibility of biomaterial devices when implanted in vivo of animal models.
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Both in vitro and in vivo experiments show that PLCL maintains good histocompatibility after implantation and usually only triggers a mild, acute local inflammatory response that is self-limiting within a short period.
“Both in vitro and in vivo experiments show that PLCL maintains good histocompatibility after implantation, usually only triggers a mild, acute local inflammatory response, which is part of the normal wound healing process and is self-limiting within a short period of time [31, 32].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [31]
PLCL materials usually do not trigger severe immune responses or chronic inflammatory responses when degraded in vivo.
“Therefore, PLCL materials usually do not trigger severe immune responses or chronic inflammatory responses when degraded in vivo.”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [31]
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References 123 · Cited by 23
- Authors
- Frazão, L. P., Vieira de Castro, J., & Neves, N. M.
- Affiliations
- 3B's Research Group (PT)
- ORCID
- Neves, Nuno M.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Singapore
- Published
- 2020
- Volume
- 1250
- Pages
- 109-124
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W3039701765
- Cited by
- 23
- References
- 123
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 5
- FWCI
- 23.12
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- biomaterial biocompatibility, host immune response, foreign body reaction, fibrous encapsulation, inflammation, wound healing, innate and adaptive immunity, tissue regeneration, animal models
- MeSH terms
- Animals, Biocompatible Materials, Foreign-Body Reaction, Immunity, Cellular, Inflammation, Prostheses and Implants, Models, Animal
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