From genes to phenotype: dynamical systems and evolvability
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Genotype space is highly redundant, meaning that a huge number of genotypes are consistent with the same phenotype.
“This is particularly relevant when dealing with the emergence of molecular functions, where the genotype space is highly redundant [46], meaning that a huge number of genotypes are consistent with the same phenotype [47].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [47]
Early literature on constraints in development supported the concept that there are limits to the possible in terms of forms and developmental paths.
“As we mentioned above, the early literature on constraints in development supported the concept that there are limits to the possible in terms of forms and developmental paths [47].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [47]
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Manrubia, S., Cuesta, J. A., Aguirre, J., Ahnert, S. E., Altenberg, L., Cano, A. V., Catalán, P., Diaz-Uriarte, R., Elena, S. F., García-Martín, J. A., et al. (2021) · Physics of Life Reviews · doi:10.1016/j.plrev.2021.03.004 · Cited by 88 · see citing works
Epigenetically Heritable Alteration of Fly Development in Response to Toxic Challenge
Stern, S., Fridmann-Sirkis, Y., Braun, E., & Soen, Y. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.03.012 · Cited by 80 · see citing works
Fundamental constraints to the logic of living systems
Solé, R., Kempes, C. P., Corominas-Murtra, B., De Domenico, M., Kolchinsky, A., Lachmann, M., Libby, E., Saavedra, S., Smith, E., & Wolpert, D. (2024) · Interface Focus · doi:10.1098/rsfs.2024.0010 · Cited by 34 · see citing works
“As we mentioned above, the early literature on constraints in development supported the concept that there are limits to the possible in terms of forms and developmental paths [47].”
BackgroundNakhle, F., & Harfouche, A. L. (2021) · Patterns · doi:10.1016/j.patter.2021.100323 · Cited by 28 · see citing works
Structured community transitions explain the switching capacity of microbial systems
Long, C., Deng, J., Nguyen, J., Liu, Y.-Y., Alm, E. J., Solé, R., & Saavedra, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312521121 · Cited by 19 · see citing works
- Authors
- Alberch, P.
- Affiliations
- Museo Nacional de Ciencias Naturales (ES)
- Corresponding author
- Alberch, P.
- Venue
- Genetica
- Published
- 1991-05
- Volume
- 84
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0016-6707 (ISSN-L)
- 1573-6857
- OpenAlex
- W2047919241
- Cited by
- 300
- References
- 0
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 22 · 2023: 14 · 2022: 12 · 2021: 45 · 2020: 13 · 2019: 17 · 2018: 26 · 2017: 12 · 2016: 19 · 2015: 14 · 2014: 17 · 2013: 9 · 2012: 8
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Genetica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- evolvability, dynamical systems, gene expression, phenotypes, gene regulatory networks, gene regulatory evolution
- MeSH terms
- Chromosome Mapping, Biological Evolution, Genes, Genotype, Mathematics, Phenotype, Phylogeny, Selection, Genetic, Genetic Variation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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