Phagocytosis of bacterial aggregates by granulocytes
Abstract
A study was conducted on the granulocytic phagocytosis of bacterial aggregates obtained under ideal environmental conditions. For the strains studied, aggregation was favored by low salt concentrations, low pH and temperatures between 30 degrees C and 40 degrees C. Our results show that the phagocytic capacity of granulocytes depends on the type and size of these aggregates. Those formed by a smaller number of cells are more easily phagocytized than the larger ones.
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Auto-aggregation is associated with enhanced colonization, inhibition of pathogenic infections and immunomodulation of the intestinal mucosa.
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Autoaggregation and microcolony formation may play a role in protection from the host immune system.
“Autoaggregation and microcolony formation may also play a role in protection from the host immune system [13],[14].”
From Bacterial autoaggregation (2018) · cites this paper as [14]
Aggregation impedes phagocytosis by cells of the host immune system.
“Aggregation has also been shown to influence pathogenesis by increasing tolerance against antimicrobial agents [3],[11],[114], elevating invasion frequency as well as invasion efficiency of host cells [42], impeding phagocytosis by cells of the host immune system [14], or increasing survival within phagosomes [13].”
From Bacterial autoaggregation (2018) · cites this paper as [14]
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- Authors
- Galdiero, F., Carratelli, C. R., Nuzzo, I., Bentivoglio, C., & Galdiero, M.
- Affiliations
- University of Naples Federico II (IT)
- ORCID
- Galdiero, M.
- Venue
- European Journal of Epidemiology
- Published
- 1988-12
- Volume
- 4
- Issue
- 4
- Pages
- 456-460
- ISSN
- 0393-2990 (ISSN-L)
- 0392-2990
- 1573-7284
- OpenAlex
- W1979698990
- Cited by
- 21
- References
- 10
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- phagocytosis, granulocytes, bacterial aggregates, bacterial aggregation, phagocytic capacity, salt concentration, pH, temperature, aggregate size
- MeSH terms
- Animals, Bacteria, Granulocytes, Humans, Phagocytosis, Mice
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