Integrins: cell adhesives and modulators of cell function

Bosman, Fred T.

doi:10.1007/bf00159282

Cited by 79Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsBone and Dental Protein Studies

Integrins: cell adhesives and modulators of cell function

Bosman, Fred T.·1993·The Histochemical Journal

DOI 10.1007/bf00159282

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Abstract

Integrins encompass a family of cell-surface molecules which play a crucial role in cell-cell and cell-extracellular matrix interaction. Of these heterodimeric transmembrane glycoproteins (consisting of an alpha and beta chain) as yet at least 20 different types have been described, all with a different pattern of reactivity with extracellular matrix components. In this review the cell and tissue distribution of the integrins is discussed, with special emphasis on immunohistochemical localization of the beta 1 integrins and the alpha 6 beta 4 integrin. The beta 1 integrins comprise a subfamily in which eight alpha chains combine with one beta (the beta 1) chain. The alpha 2 beta 1, alpha 3 beta 1 and alpha 6 beta 1 and the alpha 6 beta 4 integrins are expressed on a wide variety of epithelia on the basolateral surface or exclusively on the basal surface facing the basement membrane (e.g. alpha 6 beta 1 and alpha 6 beta 4). Leucocyte integrins, which share a common beta 2 chain, occur almost exclusively on white blood cells and their precursors. The vitronectin receptors, which share a common alpha v chain, occur in a wide variety of cell types. Integrins play a major role in the interaction of the cell with the extracellular matrix in order to create and maintain tissue architecture. It has become clear, however, that through integrin-ligand interaction cell function is also modulated. Furthermore, in pathological conditions integrins play a role of some significance. Integrins mediate leucocyte traffic in developing inflammatory processes and function in neoplastic growth when it comes to invasion and metastasis.

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Authors: Bosman, F. T.
Affiliations: Erasmus University Rotterdam (NL)
Corresponding author: Bosman, Fred T.
ORCID: Bosman, Fred T.
Venue: The Histochemical Journal
Publisher: Springer Science and Business Media LLC
Published: 1993-07
Volume: 25
Issue: 7
Pages: 469-477
ISSN: 0018-2214 (ISSN-L)
1573-6865
DOI: 10.1007/bf00159282
OpenAlex: W2013214344
Cited by: 79
References: 69
Citations by year: 2024: 1 · 2021: 2 · 2019: 1 · 2018: 2 · 2015: 1 · 2014: 1
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: The Histochemical Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords: integrins, beta1 integrin, alpha2beta1 integrin, beta2 integrins, integrin αvβ3, cell-matrix interactions, cell adhesion, basement membrane, epithelium, inflammation, metastasis, tumor invasion, integrin-ligand interaction, immunolocalization
MeSH terms: Amino Acid Sequence, Animals, Cell Adhesion, Epithelial Cells, Epithelium, Humans, Immunohistochemistry, Leukocytes, Molecular Sequence Data, Neoplasms, Tissue Distribution, Tumor Cells, Cultured, Integrins

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Integrins: cell adhesives and modulators of cell function

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