Clinical features of type III hyperlipoproteinemia: analysis of 64 patients
Abstract
The clinical and biochemical characteristics of type III hyperlipoproteinemia are described in 64 patients (35 males and 29 females). Homozygosity for apolipoprotein E2, the presence of an abnormally cholesterol-rich very low density lipoprotein fraction (beta-VLDL) and an elevated ratio of very low density lipoprotein cholesterol to plasma triglycerides (> 0.3; normal ratio about 0.2) were the basis for the diagnosis. Mean serum cholesterol and triglyceride concentrations at the first visit in the clinic were 426 +/- 221 and 719 +/- 996 mg/dl, respectively. The mean age at diagnosis of the disorder was 49 years in males and 53 years in females. There was a high prevalence of obesity (72%), xanthomas (42%), and atherosclerosis (39%), especially peripheral vascular disease (31%). Early and correct diagnosis of this familial lipoprotein disorder seems necessary because of the prompt and beneficial response to therapeutic interventions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Palmar xanthomas occur in type III HLP patients at a rate of 39%.
“Typical (and nearly pathognomonic) findings are palmar xanthomas (orangeyellowish discolourations of the palmar creases) which have been reported to occur in these patients at a rate of 39%.3”
From Severe xanthomatosis associated with familial apolipoprotein E deficiency. (1996) · cites this paper as [3]
Cites
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741 · see citing works
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Young, S., Veniant, M., Beigneux, A., Bensadoun, A., & Fong, L. (2008) · Current Drug Targets · doi:10.2174/138945008783755629 · Cited by 33 · see citing works
Severe xanthomatosis associated with familial apolipoprotein E deficiency.
Feussner, G. (1996) · Journal of Clinical Pathology · doi:10.1136/jcp.49.12.985 · Cited by 10 · see citing works
Self-citation
- Authors
- Feussner, G., Wagner, A., Kohl, B., & Ziegler, R.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Ziegler, R.
- Venue
- The Clinical Investigator
- Published
- 1993
- Volume
- 71
- Issue
- 5
- Pages
- 362-6
- ISSN
- 0946-2716 (ISSN-L)
- 0941-0198
- 1432-1440
- OpenAlex
- W2092891802
- Cited by
- 27
- References
- 2
- Citations by year
- 2022: 2 · 2020: 2 · 2014: 2
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type III hyperlipoproteinemia, familial hypertriglyceridemia, apolipoprotein E2, VLDL, obesity, xanthoma, atherosclerosis, peripheral vascular disease, serum cholesterol, serum triglycerides, age at diagnosis
- MeSH terms
- Adult, Apolipoproteins E, Arteriosclerosis, Cholesterol, Female, Homozygote, Humans, Hyperlipoproteinemia Type III, Lipoproteins, VLDL, Male, Middle Aged, Obesity, Triglycerides, Xanthomatosis, Peripheral Vascular Diseases, Apolipoprotein E2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
