The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Insulin and apolipoprotein A-1/C-III gene polymorphisms relating to hypertriglyceridaemia and diabetes mellitus
Open accessAbstract
Two gene specific probes have been used to identify polymorphic DNA loci on chromosome 11 close to the insulin and apoprotein A-1 genes in a genetic analysis of hypertriglyceridaemic patients with and without co-existing diabetes. Of the 45 patients studied with both probes, 15 were diabetic of whom nine possessed class 3/3 insulin polymorphism genotypes, compared with none in the non-diabetic group (p less than 0.001; chi 2 test). In contrast, an uncommon apolipoprotein A-1 polymorphism was found to be equally distributed in the diabetic and the non-diabetic patients. No co-segregation of these two particular genetic polymorphisms was found in either patient group. The differing associations of the two disease-related polymorphism genotypes in patients with hypertriglyceridaemia with or without co-existing diabetes may possibly reflect differing aetiologies of the hyperlipidaemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Apo C-III is a genetically validated target to reduce ASCVD risk.
“and is a genetically validated target to reduce ASCVD risk.8–10,64–66”
From Clinical review on triglycerides (2020) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
Botstein, D., White, R. L., Skolnick, M. H., & Davis, R. W. (1980) · Europe PMC (PubMed Central) · Cited by 8,327
Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.
Kunkel, L. M., Smith, K. D., Boyer, S. H., Borgaonkar, D. S., Wachtel, S. S., Miller, O. J., Breg, W. R., Jones, H. W., & RARY, J. M. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.3.1245 · Cited by 1,334
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.
Bell, G. I., Karam, J. H., & Rutter, W. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5759 · Cited by 883
[9] Gel electrophoresis of restriction fragments
Southern, E. M. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)68011-4 · Cited by 648
Bell, G. I., Selby, M., & Rutter, W. J. (1982) · Nature · doi:10.1038/295031a0 · Cited by 514
Pykälistö, O., Smith, P. H., & Brunzell, J. D. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108185 · Cited by 284
25-hydroxycholecalciferol stimulation of muscle metabolism.
Birge, S. J., & Haddad, J. G. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108184 · Cited by 260
DNA POLYMORPHISM ADJACENT TO HUMAN APOPROTEIN A-1 GENE: RELATION TO HYPERTRIGLYCERIDAEMIA
Rees, A., Stocks, J., Shoulders, C. C., Galton, D. J., & Baralle, F. E. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91440-x · Cited by 241
Self-citationSanten, R. J. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.130.6.833 · Cited by 166
FREQUENCY OF RISK FACTORS FOR ISCHÆMIC HEART-DISEASE IN A HEALTHY BRITISH POPULATION
Lewis, B., Wootton, I. D. P., Krikler, D. M., February, A., Chait, A., Oakley, C. M., Sigurdsson, G., Maurer, B., & Birkhead, J. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92438-6 · Cited by 165
Karathanasis, S. K., Norum, R. A., Zannis, V. I., & Breslow, J. L. (1983) · Nature · doi:10.1038/301718a0 · Cited by 144
Glueck, C. J., Levy, R. I., & Fredrickson, D. S. (1969) · Diabetes · doi:10.2337/diab.18.11.739 · Cited by 140
The Insulin Gene Is Located on the Short Arm of Chromosome 11 in Humans
Owerbach, D., Bell, G. I., Rutter, W. J., Brown, J. A., & Shows, T. B. (1981) · Diabetes · doi:10.2337/diab.30.3.267 · Cited by 104
Atherosclerosis in Diabetes Mellitus
Santen, R. J. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.1972.03650060025005 · Cited by 89
Variation in the sequence and modification state of the human insulin gene flanking regions
Ullrich, A., Dull, T. J., Gray, A., Philips, J. A., & Peter, S. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.7.2225 · Cited by 74
Evidence for diabetes mellitus and genetic forms of hypertriglyceridemia as independent entities
Brunzell, J. D., Hazzard, W. R., Motulsky, A. G., & Bierman, E. L. (1975) · Metabolism · doi:10.1016/0026-0495(75)90148-1 · Cited by 68
Insulin-independent diabetes: A defect in the activity of lipoprotein lipase in adipose tissue
Taylor, K. G., Galton, D. J., & Holdsworth, G. (1979) · Diabetologia · doi:10.1007/bf01223620 · Cited by 59
Self-citationHuman apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11
Law, S. W. T., Gray, G. J., Brewer, H. B., Sakaguchi, A. Y., & Naylor, S. L. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91485-2 · Cited by 56
Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene.
Jowett, N. I., Williams, L. G., Hitman, G. A., & Galton, D. J. (1984) · BMJ · doi:10.1136/bmj.288.6411.96 · Cited by 49
Self-citationINCIDENCE OF DIABETES IN THE FIRST 26 YEARS OF LIFE
Wadsworth, M. E. J., & Jarrett, R. J. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90812-5 · Cited by 35
[2] Directory of restriction endonucleases
Roberts, R. J. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)68004-7 · Cited by 29
Prevalence of hyperlipoproteinaemia in apparently healthy men.
Lorimer, A. R., Cox, F. C., Greaves, D., Jubb, J. S., Hawthorne, V. M., Morgan, H., & Lawrie, T. D. V. (1974) · Heart · doi:10.1136/hrt.36.2.192 · Cited by 11
Flagged first, then by citations
Cited by
Sorted by citations
Clinical review on triglycerides
Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544
Lipid-Lowering Agents: Targets Beyond PCSK9
Hegele, R. A., & Tsimikas, S. (2019) · Circulation Research · doi:10.1161/circresaha.118.313171 · Cited by 171
Ordovás, J. M., Civeira, F., Genest, J. J., Craig, S., Robbins, A. H., MEADE, T., Pocovı́, M., Frossard, P. M., Masharan, U., Wilson, P. W. F., et al. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90234-t · Cited by 145
Genetics of Coronary Heart Disease and its Risk Factors
Berg, K. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513507.ch3 · Cited by 44
Baker, W. A., Hitman, G. A., Hawrami, K., McCarthy, M. I., Riikonen, A., Tuomilehto‐Wolf, E., Nissinen, A. M., Tuomilehto, J. O., Mohan, V., Viswanathan, M., et al. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00252.x · Cited by 38
Self-citationKlein, R. L., McHenry, M. B., Lok, K. H., Hunter, S. J., Le, N., Jenkins, A. J., Zheng, D., Semler, A. J., Brown, W. V., Lyons, T. J., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2004.05.004 · Cited by 33
A DNA polymorphism of an apoprotein gene associates with the hypertriglyceridaemia of primary gout
Ferns, G., Lanham, J., Dieppe, P. A., & Galton, D. J. (1988) · Human Genetics · doi:10.1007/bf00291235 · Cited by 31
Self-citationTrembath, R. C., Thomas, D. J. B., Hendra, T. J., Yudkin, J. S., & Galton, D. J. (1987) · BMJ · doi:10.1136/bmj.294.6587.1577 · Cited by 31
Self-citationLipoprotein analyses in varying degrees of glucose tolerance
Falko, J. M., Parr, J. H., Simpson, R. N., & Wynn, V. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90892-8 · Cited by 24
DNA polymorphisms flanking the apo A-1 and insulin genes and type III hyperlipidaemia
Vella, M. A., Kessling, A. M., Jowett, N. I., Rees, A., Stocks, J., Wallis, S. C., & Galton, D. J. (1985) · Human Genetics · doi:10.1007/bf00293040 · Cited by 24
Self-citationZhang, Q., Liu, Y., Liu, B. W., Fan, P., Cavanna, J., & Galton, D. J. (1998) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1998.2712 · Cited by 20
Self-citationInsulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review
Mandrup-Poulsen, T. R., Owerbach, D., Nerup, J., Johansen, K., Ingerslev, J. K., & Hansen, A. T. (1985) · Diabetologia · doi:10.1007/bf00281989 · Cited by 17
Raffel, L. J., Vadheim, C. M., Roth, M., Klein, R., Moss, S. E., & Rotter, J. I. (1991) · Diabetologia · doi:10.1007/bf00400999 · Cited by 14
Apolipoprotein A-I gene polymorphism and susceptibility of non-insulin-dependent diabetes mellitus.
Buraczyńska, M., Hanzlik, J., & Grzywa, M. (1985) · Europe PMC (PubMed Central) · Cited by 13
Coronary artery disease and apolipoprotein A‐I/C‐III gene polymorphism: a study of Saudi Arabians
Johansen, K., Dunn, B., Tan, J., Kwaasi, A. A. A., Skotnicki, A. H., & Skotnickl, M. (1991) · Clinical Genetics · doi:10.1111/j.1399-0004.1991.tb02978.x · Cited by 12
Apolipoprotein A‐l/C‐lll gene cluster polymorphism in Saudi Arabians, Filipinos and Caucasians
Johansen, K., Skotnicki, A., Tan, J., Kwaasi, A. A. A., & Skotnicki, M. (1990) · Clinical Genetics · doi:10.1111/j.1399-0004.1990.tb03502.x · Cited by 8
[42] Genetic polymorphism in the ApoA-I/C-III complex
Shoulders, C. C., & Baralle, F. E. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28102-1 · Cited by 6
Coronary Artery Disease, HDL Cholesterol, and Insulin‐gene Flanking Sequences
Johansen, K., Skotnicki, A., Smith, R., Dunn, B., Ziady, G. M., & Skotnicki, M. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb01199.x · Cited by 5
Apolipoprotein Genes, DNA Polymorphisms and Hyperlipidemia
Shoulders, C. C., & Baralle, F. E. (1984) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7235-5_1 · Cited by 3
Diabetes mellitus, atherosclerosis, and the 5′ flanking polymorphism of the human insulin gene
Mandrup-Poulsen, T. R., Owerbach, D., Nerup, J., Johansen, K., & Hansen, A. T. (1986) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01800863 · Cited by 2
Diabetes mellitus und Gefäßkrankheiten — Gesamtschau
Standl, E., & Janka, H. U. (1989) · Springer eBooks · doi:10.1007/978-3-7091-7562-0_10 · Cited by 2
Intolérance aux hydrates de carbone: les sept questions
Grimaldi, A., Sachon, C., Bosquet, F., & Doumith, R. (1990) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(05)80862-8 · Cited by 1
Ordovás, J. M., Civeira, F., Garcés, C., & Pocovı́, M. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3690-1_9 · Cited by 1
Fettstoffwechsel bei Typ II Diabetes mellitus
Gries, F. A., & Koschinsky, T. (1986) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85459-0_104
Galton, D. J., Mattu, R. K., & Stocks, J. (1994) · Developments in cardiovascular medicine · doi:10.1007/978-94-011-1130-0_21
Self-citationDiabetes Mellitus, Atherosclerosis, and the 5’ Flanking Polymorphism of the Human Insulin Gene
Mandrup-Poulsen, T. R., Owerbach, D., Nerup, J., Johansen, K., & Hansen, A. T. (1986) · Springer eBooks · doi:10.1007/978-94-009-4131-1_10
Metadata
- Authors
- Jowett, N. I., Rees, A., Williams, L. G., Stocks, J., Vella, M. A., Hitman, G. A., Katz, J., & Galton, D. J.
- Affiliations
- St Bartholomew's Hospital (GB)
- Venue
- Diabetologia
- Published
- 1984-08
- Volume
- 27
- Issue
- 2
- Pages
- 180-183
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W68757838
- Cited by
- 26
- References
- 22
- Citations by year
- 2019: 2
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- insulin gene polymorphism, hypertriglyceridemia, diabetes mellitus, chromosome 11, genetic polymorphism, co-segregation, gene probes
- MeSH terms
- Adult, Aged, Apolipoproteins A, Apolipoproteins C, Diabetes Mellitus, Female, Humans, Insulin, Male, Middle Aged, Polymorphism, Genetic, Triglycerides, Apolipoprotein A-I, Apolipoprotein C-III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
