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Twenty-four hour profiles of plasma C-peptide in Type 1 (insulin-dependent) diabetic children
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Twenty-four hour profiles of plasma C-peptide, an index of endogenous insulin secretion, were performed in 15 Type 1 (insulin-dependent) diabetic children. Plasma C-peptide was detectable in six children, of whom four ('C-peptide producers') had peak values above normal fasting levels. In each of the six children with residual B cell function, there was a close correlation between plasma C-peptide and simultaneous blood glucose (r greater than 0.50, p less than 0.05). Post-breakfast peak blood glucose was 10.2 +/- 1.7 mmol/l (mean +/- SEM) in the 'C-peptide producers' and 18.7 +/- 1.7 mmol/l in the 11 children with low or no detectable C-peptide. Mean M-value, an index of deviation from an ideal blood glucose, was lower in the 'C-peptide producers' (p less than 0.05). It is concluded that residual functioning B cells in diabetic children behave physiologically in that insulin secretion fluctuates in accordance with the prevailing blood glucose; and that the pattern of action of injected insulin is more critical in non-C peptide producers who lack the post-prandial dampening effect provided by residual endogenous insulin secretion.
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To minimize the possibility of meal-induced endogenous insulin secretion that could dampen postprandial glucose excursions and confound assessment and interpretation of postprandial glucose fluxes and SI, the authors enrolled a homogenous cohort of individuals with C-peptide-negative diabetes on insulin pump therapy and provided a single-wave prandial insulin bolus for every meal according to ther
“Furthermore, to minimize the possibility of meal-induced endogenous insulin secretion that could dampen postprandial glucose excursions (28) and confound assessment and interpretation of postprandial glucose fluxes and SI, we enrolled a homogenous cohort of individuals with C-peptide–negative diabetes on insulin pump therapy and provided a single-wave prandial insulin bolus for every meal”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [28]
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Individual Comparisons by Ranking Methods
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Albano, J. D. M., Ekins, R. P., Maritz, G., & Turner, R. C. (1972) · European Journal of Endocrinology · doi:10.1530/acta.0.0700487 · Cited by 620
Self-citationDetermination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics
Kuzuya, H., BLIX, P. M., Horwitz, D. L., Steiner, D. F., & Rubenstein, A. H. (1977) · Diabetes · doi:10.2337/diab.26.1.22 · Cited by 603
The M‐Value, an Index of Blood‐sugar Control in Diabetics
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Human C-peptide in normal and diabetic subjects
Hedïng, L. G., & Rasmussen, S. M. (1975) · Diabetologia · doi:10.1007/bf00422322 · Cited by 104
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Insulin Antibodies and the Control of Diabetes
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Self-citationA METHOD FOR QUANTITATIVE DETERMINATION OF INSULIN ANTIBODIES IN HUMAN PLASMA
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Research works printed but not linked: 3
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- Bergmeyer HU, Bernt E, Schmidt S, Stork H (1974) D-glucose determination with hexokinase and glucose-6-phosphate dehydrogenase, In: Bergmeyer HU (ed) Methods of enzymic analysis, No 3, 2nd edn. Academic Press, New York, pp 1196?1201
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Diurnal Pattern of Insulin Action in Type 1 Diabetes
Hinshaw, L., Dalla Man, C., Nandy, D. K., Saad, A., Bharucha, A. E., Levine, J. A., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., et al. (2013) · Diabetes · doi:10.2337/db12-1759 · Cited by 125
Couper, J., Hudson, I. L., Werther, G. A., Warne, G. L., Court, J. M., & Harrison, L. C. (1991) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(91)90135-z · Cited by 36
Self-citationClinical application of insulin pumps in the management of insulin dependent diabetes.
Greene, S. A., Smith, M. A., & Baum, J. D. (1983) · Archives of Disease in Childhood · doi:10.1136/adc.58.8.578 · Cited by 21
Self-citationDiabetes Nomenclature: Classification or Grading of Severity?
Turner, R. C., Holman, R. R., Matthews, D. R., O’Rahilly, S., Rudenski, A. S., & Braund, W. J. (1986) · Diabetic Medicine · doi:10.1111/j.1464-5491.1986.tb00747.x · Cited by 12
Self-citationDiscrimination of type I from insulin-treated type II diabetic patients by C-peptide measurement
Cravarezza, P., Radaeli, E., Toffoli, C., & Rigosa, C. (1986) · Acta Diabetologica · doi:10.1007/bf02582068 · Cited by 8
Glucose Profiles in Children Two Years After the Onset of Type 1 Diabetes
Simell, T. T., Simell, O., Lammia, E., Kaprio, E. A., Hakulinen, A., Hakalax, J., & Mäenpää, J. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00114.x · Cited by 7
Metabolic rhythms in adolescents with diabetes.
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Multivariate Analysis of Glycosylated Haemoglobin in Insulin-Treated Diabetics
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Serum insulin profiles in consecutive children 2 years after the diagnosis of IDDM
Simell, T. T., Mäenpää, J., Kaprio, E. A., Hakulinen, A., Hakalax, J., Sipilä, I., Åkerblom, H. K., & Simell, O. (1995) · Diabetologia · doi:10.1007/bf02369358 · Cited by 2
Immunosuppressive therapy for diabetes mellitus
Werther, G. A. (1985) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1985.tb00156.x
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Metadata
- Authors
- Werther, G. A., Turner, R. C., Jenkins, P. A., & Baum, J. D.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- ORCID
- Jenkins, P. A.
- Venue
- Diabetologia
- Published
- 1982-04
- Volume
- 22
- Issue
- 4
- Pages
- 245-249
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2039026116
- Cited by
- 11
- References
- 11
- Citations by year
- 2013: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- C-peptide, type 1 diabetes, children, residual beta-cell function, endogenous insulin secretion, blood glucose, m-value, postprandial blood glucose, insulin therapy
- MeSH terms
- Adolescent, Blood Glucose, C-Peptide, Child, Circadian Rhythm, Diabetes Mellitus, Type 1, Female, Humans, Insulin, Male, Peptides
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