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Interrelationships of microangiopathy, plasma glucose and other risk factors in 3583 diabetic patients: A multinational study
Open accessAbstract
In a multinational study, fasting plasma glucose values in 3583 diabetic patients, aged 34-56 years, were related to the characteristics of these subjects and to the presence and severity of microangiopathy as ascertained by standardised methods. The patients were from nine different populations and ranged in number from 193 to 686 per population (London, Warsaw, Berlin (FRG), New Delhi, Tokyo, Havana, Oklahoma Indians, Arizona Pima Indians, and a national sample in Switzerland). In the total group, mean fasting plasma glucose was 8.1 mmol/l for those on diet alone, 9.7 mmol/l for those on oral agents, and 12.7 mmol/l for insulin-treated patients, of whom 25% had values exceeding 16.5 mmol/l. Since many variables were measured in each patient, it was possible to take into account many confounding factors in evaluating the relationship of plasma glucose levels to retinopathy and nephropathy.
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Hyperglycaemia and hyperinsulinemia are involved in the development of long-term complications in NIDDM.
“Furthermore,hyperglycaemia as well as hyperinsulinemia is involved in the development of long-term complications inherent in this disease [18, 19].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [19]
The Plasma Glucose and Microvascular Disease section reports more retinopathy and proteinuria with higher glycaemia, supporting the hyperglycaemia part. The Discussion describes glucose as a possible risk factor and notes that the study was cross-sectional, so it does not establish a causal role in development. The passages on insulin concern treatment status, not hyperinsulinemia; they do not support that part of the claim. (LLM, conf=0.88)
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Metadata
- Authors
- West, K. M., Ahuja, M. M. S., Bennett, P. H., Grab, B., Grabauskas, V., Mateo-de-Acosta, O., Fuller, J. H., Jarrett, R. J., Keen, H., Kosaka, K., Krolewski, A. S., Miki, E., Schliack, V., & Teuscher, A.
- Affiliations
- World Health Organization (CH)
- Venue
- Diabetologia
- Published
- 1982-06
- Volume
- 22
- Issue
- 6
- Pages
- 412-420
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1968492285
- Cited by
- 68
- References
- 8
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- Funders
- World Health Organization
- University of Oklahoma
- National Institutes of Health
- University of Oklahoma Health Sciences Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetic microangiopathy, fasting blood glucose, diabetic retinopathy, diabetic nephropathy, diabetes mellitus, insulin therapy, oral antidiabetic drugs, dietary therapy, risk factors, hyperglycemia, cross-national comparison
- MeSH terms
- Adult, Blood Glucose, Blood Pressure, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Nephropathies, Diabetic Retinopathy, Female, Humans, Insulin, Male, Middle Aged, Proteinuria, Risk
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