The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Environmentally directed mutations in the dehalogenase system of Pseudomonas putida strain PP3
Abstract
Favourable mutations involving the two dehalogenases (DehI and DehII) of Pseudomonas putida PP3 and derivative strains containing the cloned gene for DehI (dehI) occurred in response to specific environmental conditions, namely: starvation conditions; the presence of dehalogenase substrates (halogenated alkanoic acids--HAAs) which were toxic to P. putida; and/or the presence of a potential growth substrate. Fluctuation tests showed that these mutations were environmentally directed by the presence of HAAs. The mutations were associated with complex DNA rearrangements involving the movement of dehI located on a transposon DEH. Some mutations resulted in switching off the expression of either one or both of the dehalogenases, events which were effective in protecting P. putida from toxic compounds in its growth environment. Other mutations partially restored P. putida's dehalogenating capability under conditions where toxic substrates were absent. Restoration of the capability to untilize HAAs was favoured when normal growth substrates were present in the environment.
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“Difluoroacetate has been found to be much more recalcitrant to biodegradation (Alexandrino et al., 2018), while dichloroacetate is readily biodegraded (Slater et al., 1985; Busto et al., 1992; Thomas et al., 1992; Blackburn et al., 2000; Dixon et al., 2000; Pandey et al., 2017; Chen et al., 2021).”
From Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances (2022) · cites this paper as Thomas et al., 1992
Citations
Cites
Mutations of bacteria from virus sensitivity to virus resistance
Luria, S. E., & Delbrück, M. (1943) · Genetics · doi:10.1093/genetics/28.6.491 · Cited by 3,894
Bagdasarian, M., Lurz, R., Rückert, B., Franklin, F. C. H., Bagdasarian, M. M., Frey, J., & Timmis, K. N. (1981) · Gene · doi:10.1016/0378-1119(81)90080-9 · Cited by 1,106
Cairns, J., Overbaugh, J., & Miller, S. (1988) · Nature · doi:10.1038/335142a0 · Cited by 1,025 · cited 2×
“putida PP3, and for the mutation to 2mcpa + for those strains carrying the cloned, but non-expressed, dehI, the mutations were environmentally directed responding to the presence of HAAs in the environment (Cairns et al. 1988; Hall 1990).”
BackgroundPlasmids of medical, environmental and commercial importance
Szybalski, E. H. (1980) · Gene · doi:10.1016/0378-1119(80)90148-1 · Cited by 343
Spontaneous point mutations that occur more often when advantageous than when neutral.
Hall, B. G. (1990) · Genetics · doi:10.1093/genetics/126.1.5 · Cited by 324
Hall, B. G. (1988) · Genetics · doi:10.1093/genetics/120.4.887 · Cited by 198
Enzyme evolution in a microbial community growing on the herbicide Dalapon
Senior, E., Bull, A. T., & Slater, J. H. (1976) · Nature · doi:10.1038/263476a0 · Cited by 185
Self-citationThe Growth of Pseudomonas putida on Chlorinated Aliphatic Acids and its Dehalogenase Activity
Slater, J. H., Lovatt, D., Weightman, A. J., Senior, E., & Bull, A. T. (1979) · Journal of General Microbiology · doi:10.1099/00221287-114-1-125 · Cited by 111
Self-citationWeightman, A. J., Weightman, A. L., & Slater, J. H. (1982) · Microbiology · doi:10.1099/00221287-128-8-1755 · Cited by 102
Self-citationNew data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis
Mittler, J., & Lenski, R. (1990) · Nature · doi:10.1038/344173a0 · Cited by 95
Research works printed but not linked: 1
- SokalRR, RothJR (1981) Biometry. W. H. Freeman, San Francisco
Cited by
Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation
Foster, P. L. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.57 · Cited by 182
Wackett, L. P. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.13928 · Cited by 165
Metadata
- Authors
- Thomas, A. W., Lewington, J., Hope, S., Topping, A. W., Weightman, A. J., & Slater, J. H.
- Venue
- Archives of Microbiology
- Published
- 1992-08
- Volume
- 158
- Issue
- 3
- Pages
- 176-182
- ISSN
- 0302-8933
- 1432-072X
- Cited by
- 25
- References
- 20
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- Thomas, A. W., Lewington, J., Hope, S., Topping, A. W., Weightman, A. J., & Slater, J. H. (1992). Environmentally directed mutations in the dehalogenase system of Pseudomonas putida strain PP3. Archives of Microbiology. https://doi.org/10.1007/bf00290813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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