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Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers
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In the citing paper
“Piperine also enhances the bioavailability of several other compounds including phenytoin, coenzyme Q10, theophylline, and propranolol (Bano et al., 1991; Badmaev et al., 2000; Pattanaik et al., 2006).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Bano et al., 1991
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Research works printed but not linked: 10
- Atal CK, Zutshi U, Rao PG (1981) Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol 4: 229?232 · DOI
- Zutshi RK, Singh R, Zutshi U, Johri RK, Atal CK (1985) Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc Physicians India 33: 223?226
- Bano G, Amla V, Raina RK, Johri RK, Zutshi U, Chopra CL (1987) The effect of piperine on kinetics of phenytoin in healthy volunteers. Planta Medica 53: 568?569 · DOI
- Shand DG, Nuckoll EN, Gates JA (1970) Plasma propranolol levels in adults with observation in four children. Clin Pharmacol Ther 11: 112?120 · DOI
- Bano G, Raina RK, Sharma DB (1986) Pharmacokinetics of carbamazepine in protein energy malnutrition. Pharmacology 32: 232?236 · DOI
- Shargel L, Yu ABC (1980) Review of mathematical fundamentals. In: Applied biopharmaceutics and pharmacokinetics Appleton Century Crofts, New York, pp 1?12
- Gibaldi M (1984) Introduction to pharmacokinetics Biopharmaceutics and Clinical pharmacokinetics. Philadelphia, Lea and Febiger, Philadelphia, pp 1?16
- Atal CK, Dubey RK, Singh J (1985) Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther 232: 258?262
- Leahey WJ, Neill JD, Varma MP, Shanks RG (1980) Comparison of the efficacy and pharmacokinetics of conventional propranolol and a long acting preparation of propranolol. Br J Clin Pharmacol 9: 33?40 · DOI
- Piyachaturawat P, Glinsukon T, Toskulkao C (1983) Acute and Subacute toxicity of piperine in mice, rats and hamsters. Toxicol Lett 16: 351?359 · DOI
Cited by
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Srinivasan, K. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390601062054 · Cited by 821
Smith, A., Giunta, B., Bickford, P. C., Fountain, M., Tan, J., & Shytle, R. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.012 · Cited by 280
Volak, L. P., Ghirmai, S., Cashman, J. R., & Court, M. H. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.020552 · Cited by 214
Identification of drugs that interact with herbs in drug development
Zhou, S.-F., Zhou, Z.-W., Li, C.-G., Chen, X., Yu, X., Xue, C. C., & Herington, A. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.06.004 · Cited by 178
Gurley, B., Fifer, E., & Gardner, Z. (2012) · Planta Medica · doi:10.1055/s-0031-1298331 · Cited by 165
Metadata
- Authors
- Bano, G., Raina, R. K., Zutshi, U., Bedi, K. L., Johri, R. K., & Sharma, S. C.
- Venue
- European Journal of Clinical Pharmacology
- Published
- 1991-12
- Volume
- 41
- Issue
- 6
- Pages
- 615-617
- ISSN
- 0031-6970
- 1432-1041
- Cited by
- 157
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. https://app.cochat.ai/papers/10.1007/bf00314996
- The paper
- Bano, G., Raina, R. K., Zutshi, U., Bedi, K. L., Johri, R. K., & Sharma, S. C. (1991). Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. European Journal of Clinical Pharmacology. https://doi.org/10.1007/bf00314996
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
