Identification of drugs that interact with herbs in drug development

Zhou, Shu-Feng; Zhou, Zhi-Wei; Li, Chun-Guang; Chen, Xiao; Yu, Xiyong; Xue, Charlie Changli; Herington, Adrian

doi:10.1016/j.drudis.2007.06.004

Cited by 178Complementary and Alternative Medicine StudiesPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Identification of drugs that interact with herbs in drug development

Zhou, Shu-Feng, Zhou, Zhi-Wei, Li, Chun-Guang, Chen, Xiao, Yu, Xiyong, Xue, Charlie Changli, Herington, Adrian·2007·Drug Discovery Today

DOI 10.1016/j.drudis.2007.06.004

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Abstract

To date, several clinically important drugs have been identified that interact with commonly used herbs. These drugs include (among others) warfarin, midazolam, digoxin, amitriptyline, indinavir, cyclosporine, tacrolimus and irinotecan. Importantly, many of these drugs have very narrow therapeutic indices. Most of them are substrates for cytochrome P450s (CYPs) and/or P-glycoprotein (P-gp). Because drug-herb interactions can significantly affect circulating levels of drug and, hence, alter the clinical outcome, the identification of drugs that interact with commonly used herbal medicines has important implications in drug development. In silico, in vitro, animal and human studies are often used to identify drug interactions with herbs. We propose that drug-herb and herb-CYP interaction studies should be incorporated into drug development.

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Many herbs have been found to exhibit adverse drug reactions.
“recently many of the herbs were found to exhibit adverse drug reactions [267].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [267]
Coadministration of herbal drugs with prescribed drugs may cause serious adverse effects.
“Coadministration of herbal drugs with prescribed drugs may result in serious adverse effects.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [267]

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PTP70-2, a novel polysaccharide from Polygala tenuifolia, prevents neuroinflammation and protects neurons by suppressing the TLR4-mediated MyD88/NF-κB signaling pathway
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SSR identification and phylogenetic analysis in four plant species based on complete chloroplast genome sequences
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Authors: Zhou, S.-F., Zhou, Z.-W., Li, C.-G., Chen, X., Yu, X., Xue, C. C., & Herington, A.
Affiliations: Queensland University of Technology (AU)
Nanchang University (CN)
RMIT University (AU)
Sun Yat-sen University (CN)
Corresponding author: Zhou, Shu-Feng
ORCID: Li, Chun-Guang
Xue, Charlie Changli
Herington, Adrian
Venue: Drug Discovery Today
Publisher: Elsevier BV
Published: 2007-08
Volume: 12
Issue: 15-16
Pages: 664-673
ISSN: 1359-6446 (ISSN-L)
DOI: 10.1016/j.drudis.2007.06.004
OpenAlex: W2028023433
Cited by: 178
References: 115
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 14 · 2014: 13 · 2013: 18 · 2012: 14
FWCI: 1.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Drug Discovery Today (publishedVersion)
PubMed (publishedVersion)
QUT ePrints (Queensland University of Technology) (submittedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: herb-drug interactions, herbal medicine, cytochrome P450, P-glycoprotein, narrow therapeutic index drugs, warfarin, midazolam, digoxin, amitriptyline, indinavir, cyclosporine, tacrolimus, irinotecan, drug development
MeSH terms: Animals, Pharmaceutical Preparations, Humans, Models, Biological, Technology, Pharmaceutical, Drug Design, Plant Preparations, Herb-Drug Interactions, Drug-Related Side Effects and Adverse Reactions

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Identification of drugs that interact with herbs in drug development

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