Psychiatric disorders in the encephalitic form of multiple sclerosis
Abstract
Multiple sclerosis lesions may occur predominantly in the hemispheric white matter and cause various psychiatric disorders such as remitting-relapsing endoform or exogenous psychosis, organic personality alterations and dementia. Nineteen patients suffering from this encephalitic form of multiple sclerosis as diagnosed by characteristic CSF immunoglobulin findings are analysed according to established psychopathological criteria. All cases began with psychiatric symptoms and neurological signs were either absent or overlooked. Several patients developed typical encephalomyelitic symptoms in successive relapses, but other remained with psychiatric disorders over many years. Only four patients had retrobulbar neuritis, but seven suffered from epileptic seizures. The humoral immune response was characterized by a strong dominance of IgG and a local synthesis of polyspecific antibodies against measles, rubella and varicella/zoster virus. The mononuclear CSF pleocytosis was comparatively marked with cell counts up to 180/microliter.
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Increased phasic activity of dopaminergic neurons could drown out dopaminergic activity associated with reinforcing or motivationally salient stimuli, leading to negative symptoms such as anhedonia, avolition, and apathy.
“With respect to the etiology of negative symptoms, it is possible that the increased phasic activity of these dopaminergic neurons could ''drown out'' the dopaminergic activity typically associated with reinforcing or motivationally salient stimuli, as per the suggestion of Roiser et al. 69 The consequently reduced valence of typically reinforcing stimuli could underlie such negative symptoms of”
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- Authors
- Felgenhauer, K.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Felgenhauer, K.
- Venue
- Journal of Neurology
- Published
- 1990-02
- Volume
- 237
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2083955800
- Cited by
- 36
- References
- 28
- Citations by year
- 2024: 1 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, mental illness, psychosis, organic personality disorder, dementia, retrobulbar neuritis, epileptic seizures, IgG, measles antibodies, rubella antibodies, varicella-zoster virus antibodies, cerebrospinal fluid pleocytosis, humoral immune response
- MeSH terms
- Adolescent, Adult, Antibodies, Viral, Chronic Disease, Encephalitis, Female, Humans, Male, Measles virus, Middle Aged, Multiple Sclerosis, Rubella virus, Herpesvirus 3, Human, Neurocognitive Disorders
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