Cited by 36Multiple Sclerosis Research StudiesAutoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and Disorders

Psychiatric disorders in the encephalitic form of multiple sclerosis

Felgenhauer, K.·1990·Journal of Neurology

Abstract

Multiple sclerosis lesions may occur predominantly in the hemispheric white matter and cause various psychiatric disorders such as remitting-relapsing endoform or exogenous psychosis, organic personality alterations and dementia. Nineteen patients suffering from this encephalitic form of multiple sclerosis as diagnosed by characteristic CSF immunoglobulin findings are analysed according to established psychopathological criteria. All cases began with psychiatric symptoms and neurological signs were either absent or overlooked. Several patients developed typical encephalomyelitic symptoms in successive relapses, but other remained with psychiatric disorders over many years. Only four patients had retrobulbar neuritis, but seven suffered from epileptic seizures. The humoral immune response was characterized by a strong dominance of IgG and a local synthesis of polyspecific antibodies against measles, rubella and varicella/zoster virus. The mononuclear CSF pleocytosis was comparatively marked with cell counts up to 180/microliter.

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Crossref · 10.1007/bf00319661

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28 of 28 references verified0 citation errors · 0 not checkable

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  • Increased phasic activity of dopaminergic neurons could drown out dopaminergic activity associated with reinforcing or motivationally salient stimuli, leading to negative symptoms such as anhedonia, avolition, and apathy.

    “With respect to the etiology of negative symptoms, it is possible that the increased phasic activity of these dopaminergic neurons could ''drown out'' the dopaminergic activity typically associated with reinforcing or motivationally salient stimuli, as per the suggestion of Roiser et al. 69 The consequently reduced valence of typically reinforcing stimuli could underlie such negative symptoms of”

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Authors
Felgenhauer, K.
Affiliations
University of Göttingen (DE)
Corresponding author
Felgenhauer, K.
Venue
Journal of Neurology
Published
1990-02
Volume
237
Issue
1
Pages
11-18
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
OpenAlex
W2083955800
Cited by
36
References
28
Citations by year
2024: 1 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 1
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
multiple sclerosis, mental illness, psychosis, organic personality disorder, dementia, retrobulbar neuritis, epileptic seizures, IgG, measles antibodies, rubella antibodies, varicella-zoster virus antibodies, cerebrospinal fluid pleocytosis, humoral immune response
MeSH terms
Adolescent, Adult, Antibodies, Viral, Chronic Disease, Encephalitis, Female, Humans, Male, Measles virus, Middle Aged, Multiple Sclerosis, Rubella virus, Herpesvirus 3, Human, Neurocognitive Disorders

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