Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus in palm-oil medium
Abstract
Palm and palm-kernel oils and their olein and stearin fractions were suitable as the main carbon sources for growth and production of clavulanic acid by Streptomyces clavuligerus. However, oleic and lauric acids were not utilized for growth. A spontaneous mutant, which was selected for higher cephamycin C production, also produced more clavulanic acid with these oils in the medium.
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In Lee and Ho (1996), no clavulanic acid production was observed in glycerol-containing media, but higher production occurred in sucrose media (3.63 mg/L).
“When comparing between glycerol and sucrose as a sole carbon source, Lee and Ho (1996) observed no production of clavulanic acid in media added with glycerol, but higher production of the compound in media with sucrose (3.63 mg/L).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Lee and Ho (1996)
Lee and Ho (1996) revealed relatively low clavulanic acid production in media containing different fractions of palm oil or its purified major constituents.
“An earlier study revealed a relatively low production of clavulanic acid in media containing different fractions of palm oil or its purified, major constituents (e.g., palmitic acid, stearic acid, lauric acid, oleic acid) (Lee and Ho, 1996).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Lee and Ho, 1996
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
- Authors
- Lee, P. C., & Ho, C. C.
- Affiliations
- University of Malaya (MY)
- Venue
- World Journal of Microbiology and Biotechnology
- Published
- 1996-01
- Volume
- 12
- Issue
- 1
- Pages
- 73-75
- ISSN
- 0959-3993 (ISSN-L)
- 1573-0972
- OpenAlex
- W2022974400
- Cited by
- 25
- References
- 0
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- World Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia, Tecnología y Medio Ambiente
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- clavulanic acid, cephamycin C, Streptomyces clavuligerus, palm oil, palm kernel oil, olein, stearin, carbon source, oleic acid, lauric acid, spontaneous mutants, antibiotic production
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