The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A two-step model of secretion control in neuroendocrine cells
Open accessAbstract
Recent experiments on a variety of neuroendocrine cells indicate that intense stimuli readily depress the secretory response. The most likely explanation for this depression is that a pool of release-ready granules is depleted. We present a two-step model of secretion that allows one to simulate the dynamics of such a pool for different time courses of free intracellular Ca concentration [Ca2+]i. We derive rate constants of the model from two types of experiment and find that, for the simplest type of model, not only the rate of consumption (exocytosis) but also the rate of vesicle supply to the pool of release-ready granules must be made Ca-dependent. Given these functional dependences a variety of results from the literature can be simulated. In particular, the model predicts the occurrence of secretory depression and augmentation under appropriate conditions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Capacitative calcium entry revisited
Putney, J. W. (1990) · Cell Calcium · doi:10.1016/0143-4160(90)90016-n · Cited by 1,487
Cited by
Neher, E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80983-6 · Cited by 1,010
Self-citationBurgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Calcium dependence of the rate of exocytosis in a synaptic terminal
Heidelberger, R., Heinemann, C., Neher, E., & Matthews, G. (1994) · Nature · doi:10.1038/371513a0 · Cited by 745
Self-citationHigh-frequency firing helps replenish the readily releasable pool of synaptic vesicles
Wang, L.-Y., & Kaczmarek, L. K. (1998) · Nature · doi:10.1038/28645 · Cited by 613
Calcium signaling and exocytosis in adrenal chromaffin cells
García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., & García-Sancho, J. (2006) · Physiological Reviews · doi:10.1152/physrev.00039.2005 · Cited by 349
Metadata
- Authors
- Heinemann, C., von Rüden, L., Chow, R. H., & Neher, E.
- Venue
- Pflügers Archiv
- Published
- 1993-07
- Volume
- 424
- Issue
- 2
- Pages
- 105-112
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- OpenAlex
- W2083973947
- Cited by
- 201
- References
- 1
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A two-step model of secretion control in neuroendocrine cells. https://app.cochat.ai/papers/10.1007/bf00374600
- The paper
- Heinemann, C., von Rüden, L., Chow, R. H., & Neher, E. (1993). A two-step model of secretion control in neuroendocrine cells. Pflügers Archiv. https://doi.org/10.1007/bf00374600
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
