Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release
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Secretory granules in β-cells belong to at least two functionally distinct pools: the readily releasable pool (RRP) and the reserve pool (RP).
“Secretory granules in β-cells belong to (at least) two functionally distinct pools: the readily releasable pool (RRP) and the reserve pool (RP) (472).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [472]
In “Dynamics of Vesicle Pools” (indexed as Abstract; page unavailable), Neher describes functionally distinct vesicle pools and an immediately releasable store supplied by a larger store. The copy also discusses readily releasable secretory granules in neuroendocrine cells, but it does not establish that β-cell granules specifically belong to an RRP and a reserve pool (RP). (LLM, conf=0.84)
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- Authors
- Neher, E.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Corresponding author
- Neher, Erwin
- ORCID
- Neher, Erwin
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 20
- Issue
- 3
- Pages
- 389-399
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1965893090
- Cited by
- 1,010
- References
- 1
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 22 · 2021: 12 · 2020: 22 · 2019: 27 · 2018: 25 · 2017: 25 · 2016: 25 · 2015: 35 · 2014: 34 · 2013: 37 · 2012: 39
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- vesicle pools, calcium microdomains, neurotransmitter release, synaptic transmission, presynaptic terminals, synaptic plasticity, vesicle docking, exocytosis, synaptic depression, presynaptic calcium channels
- MeSH terms
- Calcium, Synaptic Transmission, Synaptic Vesicles, Neurotransmitter Agents
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