The relationships of concentrations of insulin, intact proinsulin and 32–33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects

Nagi, D. K., Hendra, T. J., Ryle, A. J., Cooper, T. M., Temple, R. C., Clark, P. M. S., Schneider, A. E., Hales, C. N. +1 more·1990·Diabetologia
DOI 10.1007/bf00404140

Cited by (198)

Items 101–198 of 198

  1. Up-regulation of PAI-1 synthesis by insulin and proinsulin in HEP G2 cells but not in endothelial cells
    Marie‐Christine Alessi, Francine J. Anfosso, Mireille Henry, Franck Peiretti, Gilles Nalbone, Irène Juhan-Vague · 1995 · Fibrinolysis and Proteolysis
  2. Left ventricular mass and arterial compliance: relation to coronary heart disease and its risk factors in South Indian adults
    Kalyanaraman Kumaran, Caroline H. D. Fall, Christopher Martyn, M. Vijayakumar, Cláudia Stein, Rosie Shier · 2002 · International Journal of Cardiology
  3. A Novel Point Mutation in the Insulin Gene Giving Rise to Hyperproinsulinemia
    Margaret Warren-Perry, Susan E. Manley, Diane Ostrega, Kenneth S. Polonsky, Sandra Mussett, Phil Brown, Robert C. Turner · 1997 · The Journal of Clinical Endocrinology & Metabolism
  4. Separation and quantitation of serum proinsulin and proinsulin intermediates in humans
    Susanne Linde, Michael Einar Røder, SVEND G. HARTLING, Christian Binder, Benny Sabroe Welinder · 1991 · Journal of Chromatography A
  5. HOMA-Estimated Insulin Resistance Is Associated with Hypertension in Iranian Diabetic and Non-Diabetic Subjects
    Alireza Esteghamati, Omid Khalilzadeh, Mehrshad Abbasi, Manouchehr Nakhjavani, Leila Novin, Abdul Reza Esteghamati · 2008 · Clinical and Experimental Hypertension
  6. 8 Fibrinolysis and thrombosis
    Nuala A. Booth, Bruce Bennett · 1994 · Baillière s Clinical Haematology
  7. Insulin resistance, insulin, proinsulin, and ambulatory blood pressure in type II diabetes.
    Jonathan H. Pinkney, Vidya Mohamed‐Ali, A. E. Denver, C Foster, Mike Sampson, John S Yudkin · 1994 · Hypertension
  8. Serum insulin and ECG abnormalities suggesting coronary heart disease in the populations of Mauritius and Nauru: Cross-sectional and longitudinal associations
    Veronica Collins, Gary K. Dowse, Paul Zimmet, Jaakko Tuomilehto, K. George, M.M. Alberti, H. Gareeboo, Nan Li · 1993 · Journal of Clinical Epidemiology
  9. Insulin and cardiovascular disease: biomarker or association?
    Karin Agnes Maria Jandeleit-Dahm, Stephen P. Gray · 2012 · Diabetologia
  10. Specific insulin and proinsulin concentrations in nondiabetic South Indians
    Chamukuttan Snehalatha, Ambady Ramachandran, K. Satyavani, Vijay Viswanathan, Steven M. Haffner · 1998 · Metabolism
  11. Progress in Population Analyses of the Insulin Resistance Syndrome
    Steven M. Haffner · 1997 · Annals of the New York Academy of Sciences
  12. Effect of Race and Hypertension on Plasma Amylin Concentrations
    Joel E. Dimsdale, Orville Kolterman, Joy E. Koda, Richard A. Nelesen · 1996 · Hypertension
  13. Diabetes and Thrombosis
    David J. Schneider, Burton E. Sobel · 2005 · Humana Press eBooks
  14. Is Insulin Atherogenic?
    Paul N. Durrington · 1992 · Diabetic Medicine
  15. Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene
    Arshia Panahloo · 2003 · Atherosclerosis
  16. Diminished Fibrinolysis in Diabetes Mellitus and its Implication for Diabetic Vascular Disease
    Arshia Panahloo, John S Yudkin · 1997 · European Journal of Cardiovascular Prevention & Rehabilitation
  17. Insulin secretion and action in different stages of glucose tolerance in Asian Indians
    Chamukuttan Snehalatha, K. Satyavani, Selvaraj Sivasankari, Vijay Viswanathan, Ambady Ramachandran · 1999 · Diabetic Medicine
  18. A switch in the direction of the effect of insulin on the partitioning of hepatic fatty acids for the formation of secreted triacylglycerol occurs in vivo, as predicted from studies with perfused livers
    Susan M. Rennie, B S Park, Victor A. Zammit · 2000 · European Journal of Biochemistry
  19. Proinsulin: Biosynthesis, conversion, assay methods and clinical studies
    Thomas R. Csorba · 1991 · Clinical Biochemistry
  20. Insulin propeptides in conditions associated with insulin resistance in humans and their relevance to insulin measurements.
    A. Proudler, I. Godsland, John C. Stevenson · 1994 · Metabolism: Clinical and Experimental
  21. Association of insulin and insulin propeptides with an atherogenic lipoprotein phenotype
    Peter Båvenholm, Fredrik Karpe, Anthony J. Proudler, Per Tornvall, David Crook, Anders Hamsten · 1995 · Metabolism
  22. Evaluation of two insulin assays in insulin resistance syndrome (syndrome X).
    Steven M. Haffner, Leena Mykkänen, Rodolfo A. Valdez, Michael P. Stern · 1994 · Arteriosclerosis and Thrombosis A Journal of Vascular Biology
  23. Cross-Sectional and Prospective Associations Between Proinsulin and Cardiovascular Disease Risk Factors in a Population Experiencing Rapid Cultural Transition
    Anthony J. Hanley, Gail McKeown‐Eyssen, Stewart B. Harris, Robert Alexander Hegele, Thomas M. S. Wolever, Jeremy Kwan, Philip W. Connelly, Bernard Zinman · 2001 · Diabetes Care
  24. Autonomic dysfunction is related to impaired pancreatic β cell function in patients with coronary artery disease
    Jeremy Sayer, B Marchant, S V Gelding, Jackie A. Cooper, Adam Timmis · 2000 · Heart
  25. Good metabolic and safety profile of troglitazone alone and following alcohol in NIDDM subjects
    ELIZABETH A. FOOT, Richard Eastmond · 1997 · Diabetes Research and Clinical Practice
  26. Insulin and hypertension: Are they related?
    Woerner P. Meehan, Christine Hema Darwin, Maalouf Nb, Thomas A. Buchanan, Mohammed F. Saad · 1993 · Steroids
  27. Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes
    L. S. Hermann, Jonas Ranstam, Stein Vaaler, Arne Melander · 1999 · Diabetes Obesity and Metabolism
  28. Insulingene expression and biosynthesis
    Vincent Poitout, Roland W. Stein, Christopher J. Rhodes · 2015
  29. Capillary electrophoresis for simultaneous quantification of human proinsulin, insulin and intermediate forms
    Cinzia Arcelloni, Luca Falqui, Sabina Martinenghi, Antonio Ettore Pontiroli, Rita Clara Paroni · 1998 · Electrophoresis
  30. Disproportionately Elevated Fasting Proinsulin Levels in Normoglycemic Patients with Thalassemia major Are Correlated to the Degree of Iron Overload
    Holger Cario, Reinhard Walter Holl, Klaus‐Michael Debatin, ELISABETH KOHNE · 2003 · Hormone Research in Paediatrics
  31. Processing and release of human proinsulin-cleavage products into culture media by different engineered non-endocrine cells: a specific assessment by capillary electrophoresis
    Cinzia Arcelloni, Luca Falqui, Sabina Martinenghi, Angela Stabilini, A. E. Pontiroli, Rita Clara Paroni · 2000 · Journal of Endocrinology
  32. Do Increased Proinsulin Concentrations Explain the Excess Risk of Coronary Heart Disease in Diabetic and Prediabetic Subjects?
    Steven M. Haffner, Anthony J. Hanley · 2002 · Circulation
  33. Triglycerides and disease
    Carol A. Seymour, Christopher D. Byrne · 1993 · Postgraduate Medical Journal
  34. Which fasting triglyceride levels best reflect coronary risk? evidence from the turkish adult risk factor study
    Altan Onat, Vedat Sansoy, Beytullah Yıldırım · 2001 · Clinical Cardiology
  35. Decreased Plasminogen Activator Inhibitor‐1 Activity in Newly Diagnosed Type 2 Diabetic Patients Following Dietary Modification
    Y. Bahru, Patrick J. Kesteven, K. G. M. M. Alberti, Mark Walker · 1993 · Diabetic Medicine
  36. The Relationship Between Obesity, Plasma Immunoreactive Insulin Concentration and Blood Pressure in Newly Diagnosed Indian Type 2 Diabetic Patients
    Chittaranjan Sakerlal Yajnik, Sadanand S. Naik, Dattatray Bhat, V.M. Joshi, K.M. Shelgikar, K.G.M.M. Alberti, T. D. R. Hockaday · 1993 · Diabetic Medicine
  37. PAI-1, Obesity, and Insulin Resistance
    Irène Juhan-Vague, Marie‐Christine Alessi, Pierre‐Emmanuel Morange · 1999 · Humana Press eBooks
  38. Normal proinsulin processing despite beta-cell dysfunction in persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)
    Gil Leibowitz, N. Weintrob, Alon J. Pikarsky, ZEEV JOSEFSBERG, Heddy Landau, Benjamin Gläser, Charles Nicholas Hales, Erol Cerasi · 1996 · Diabetologia
  39. Effects of Glimepiride vs Glibenclamide on Ischaemic Heart Disease Risk Factors and Glycaemic Control in Patients with Type 2 Diabetes Mellitus
    Mary E Britton, A. E. Denver, Vidya Mohamed‐Ali, John S Yudkin · 1998 · Clinical Drug Investigation
  40. Controversies in Management of Diabetes in Patients with Coronary Heart Disease
    Nabila Abdella · 2002 · Medical Principles and Practice
  41. Insulin treatment improves microalbuminuria and other cardiovascular risk factors in patients with type 2 diabetes mellitus
    Torbjörn Lindström, ANDERS G. OLSSON, H. von Schenck, Lars C. Wallentin, Hans J. Arnqvist · 1994 · Journal of Internal Medicine
  42. Proinsulin level in diabetes mellitus measured by a new immunochemiluminometric assay.
    Ta-Jen Wu, C L Lin, R L Taylor, Pei-Chun Kao · 1995 · PubMed
  43. Role of insulin and proinsulin in diabetic vascular disease
    Nicholas J. Wareham, Christopher D. Byrne, Charles Nicholas Hales · 1995 · Metabolism
  44. The genetics and pathophysiology of type II and gestational diabetes.
    Csorba Tr, E. Al · 1995 · Critical Reviews in Clinical Laboratory Sciences
  45. Hyperproinsulinemia in obesity and in type 2 diabetes and its relation to cardiovascular disease
    Michael Einar Røder · 2017 · Expert Review of Endocrinology & Metabolism
  46. Insulin Gene Expression and Biosynthesis
    Vincent Poitout, Roland W. Stein, Christopher J. Rhodes · 2003
  47. Diabetes mellitus
    Sacks, David B. · 2012 · Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
  48. Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan—The Taipei Children Heart Study
    An‐Tsz Hsieh, Nain‐Feng Chu, Muh‐Han Shen, Der‐Min Wu, Dan-Jiang Wang, Shih-Ming Hsieh · 2003 · Clinical Biochemistry
  49. Cholesterol Rich apo B Containing Lipoproteins and Smoking are Independently Associated with Macrovascular Disease in Normotensive NIDDM Patients
    John D. Dean, Stephanie B. Matthews, John Dolben, Grace Carolan‐Rees, Stephen D. Luzio, David R. Owens · 1994 · Diabetic Medicine
  50. Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control
    Simona I. Chisalita, Torbjörn Lindström, Pär E son Jennersjö, Johan F. Paulsson, Gunilla Torstensdotter Westermark, ANDERS G. OLSSON, Hans J. Arnqvist · 2008 · Acta Diabetologica
  51. Insulin and Atherosclerosis
    Robert W. Stout · 1992 · Developments in cardiovascular medicine
  52. Plasma proinsulin in recently diagnosed type 2 diabetes mellitus
    Robert S. Schmidli, Cassandra Hagan, Russell S. Scott, James Livesey, Louisa V. Forbes · 1993 · Diabetes Research and Clinical Practice
  53. Hypertension and coronary artery disease in non-insulin dependent diabetes--cause and effect?
    John S Yudkin · 1992 · Journal of the American Society of Nephrology
  54. Proinsulin conversion intermediates: a possible source of confusion
    P. A. Halban · 1991 · Diabetologia
  55. The deidesheimer meeting: Significance of classical and new risk factors in non-insulin-dependent diabetes mellitus
    John S Yudkin · 1997 · Journal of Diabetes and its Complications
  56. Insulin, The Renin-Angiotensin-Aldosterone System and Blood Pressure
    James Francis Tait, Sylvia A. S. Tait · 1997 · Perspectives in biology and medicine
  57. Importance of Validation of Immunoassays for Intact Proinsulin
    Stephen D. Luzio, Ivan Lucas, David R. Owens · 2001 · Clinical Chemistry and Laboratory Medicine (CCLM)
  58. Lipids, thrombosis and cardiovascular disease in diabetes
    John S Yudkin · 1997 · Proceedings of The Nutrition Society
  59. Congenital factor VII deficiency: a case report.
    Latiff A. Zarina, A Hamidah, J Rohana, A.K. Faraizah, A A Noryati, R Jamal, NY Boo · 2004 · PubMed
  60. Hyperinsulinemia and VLDL Kinetics
    George A. Steiner · 1993 · Advances in experimental medicine and biology
  61. PAI-1 and the Risk of Cardiovascular Disease
    Irène Juhan-Vague, Marie‐Christine Alessi · 1998 · Medical science symposia series
  62. Is the defect in pro‐hormone processing in Type 2 diabetes mellitus restricted to the β cell?
    Gul Bano, D. A. Rodin, Anne E. White, Stephen O’Rahilly, Stephen Nussey · 2001 · Diabetic Medicine
  63. Regulation of the synthesis of plasminogen activator inhibitor type 1 (PAI-1): pathogenetic mechanism of atherosclerosis in diabetes mellitus?
    Thomas Nordt, Karlheinz Peter, W. Kübler, Christoph Bode · 1997 · Fibrinolysis and Proteolysis
  64. Myocardial infarction at a young age: mechanisms and management
    Anders Hamsten · 1991 · Vascular Medicine Review
  65. Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells
    Mingchao Jiang, Ning Wang, Yuqin Zhang, Jinjin Zhang, Youwei Li, Xiu Yan, Honghao Zhang, Chengbin Li, Youfei Guan, Bin Liang et al. · 2024 · iScience
  66. Application of size-exclusion chromatography in the investigation of the in vitro stability of proinsulin and its cleaved metabolites in human serum and plasma
    Ronald R. Bowsher, Paula F. Santa · 2009 · Journal of Chromatography B
  67. From ‘Syndrome X’ to the Thrifty Phenotype: A Reappraisal of the Insulin Resistance Theory of Atherogenesis
    Jonathan H. Pinkney, Dinesh Kumar Nagi, John S Yudkin · 1993 · Vascular Medicine Review
  68. Different binding and degradation of proinsulin, insulin and insulin-like growth factor-1 (IGF-1) in cultured renal proximal tubular cells
    P. M. Jehle, R. Fußgänger, Sylvia Stracke, Rolf Willi Grunewald, Frieder Keller · 1996 · Acta Diabetologica
  69. Type 2 Diabetes and Fibrinolysis
    Ján Staško, Peter Chudý, Daniela Kotuličová, Péter Galajda, Marian Mokáň, Peter Kubisz · 2011 · InTech eBooks
  70. Diabetes and Thrombosis
    David J. Schneider · 2023 · Contemporary cardiology
  71. Insulin and Blood Pressure
    Rijk O. B. Gans, Ab J. M. Donker · 1994 · Springer eBooks
  72. Mechanisms and effects of low plasminogen activator inhibitor type 1 activity
    Anna Ågren · 2008 · Figshare
  73. Diabetes and Thrombosis
    David J. Schneider, Burton E. Sobel · 2001 · Humana Press eBooks
  74. Low PAI‐1 activity in relation to inflammatory parameters, insulin profile and body mass index
    Anna Ågren, B. Wiman, Sam Schulman · 2008 · Journal of Internal Medicine
  75. Physiological and dysfunctional secretion of insulin.
    Bogdana Vîrgolici, Petruta R. Alexandru, Daniela Lixandru · 2012
  76. Independent Association between Fasting Plasma Insulin and Ambulatory Blood Pressure in 50-Year-Old Women
    Peter M Nilsson, Åke Schwan · 1995 · Blood Pressure
  77. Insulin treatment, NIDDM and atherosclerosis.
    Steven L. Shumak · 1991 · Europe PMC (PubMed Central)
  78. Dissimilar association of conventional immuno-reactive versus specific insulin with cardiovascular risk factors: a consequence of proinsulinaemia?
    P.A. Grootenhuis, J.M. Mooy, P.J. Kostense, C. Popp‐Snijders, L.M. Bouter, Robert J. Heine · 1998 · Diabetes Research and Clinical Practice
  79. Serum Lipoprotein Levels and Plasma Concentrations of Insulin, Intact and 32, 33 Split Proinsulin in Normoglycaemic Relatives of Patients with Type 2 Diabetes
    Susan V. Gelding, C. Andres, Ratnam Niththyananthan, W. Richmond, I. Peter Gray, D. G. Johnston · 1994 · Diabetic Medicine
  80. Effect of troglitazone on the proinsulin level in patients with type 2 diabetes mellitus: A pilot study
    Keiji Kubo · 1999 · Current Therapeutic Research
  81. No influence of proinsulin and insulin on plasma levels of plasminogen activator inhibitor type 1 and tissue plasminogen activator in young women before and during intake of contraceptive steroids
    Kresten Rubeck Petersen, Lise Kjems, Sven Olaf Skouby, Lars Franch Andersen, Jørgen Jespersen · 1996 · Metabolism
  82. Antihypertensive Treatment in Type 2 Diabetic Patients
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  83. The imbalance of coagulation and fibrinolysis in coronary heart disease and its relation to traditional risk factors
    Kaj Winther, Steen Husted, Hans Kræmmer Nielsen, Jørn Dalsgaard Nielsen · 1996 · Developments in cardiovascular medicine
  84. Zur Epidemiologie der diabetischen Angiopathie
    H.-J. Lüddecke · 1993 · Springer eBooks
  85. Insulinresistenz und metabolisches Syndrom
    Hepp Kd · 1993 · Springer eBooks
  86. Proinsulin level as a predictor of metabolic syndrome in the romanian population
    Simona Ateia, Emilia Rusu, S. Ateia, Cristescu Vasilica, Georgiana Enache, Adrian Costache, Gabriela Radulian, D Cheţa · 2013 · Romanian Journal of Diabetes Nutrition and Metabolic Diseases
  87. Proinsulin and insulin responses to a mixed meal in hypertriglyceridaemic men.
    Rousseau Mariano Gama, F Norris, S. Hampton, LM Morgan, J Wright, Vincent Marks · 1999 · Journal of Clinical Pathology
  88. ASSOCIATIONOF PROINSULIN WITH CARDIOVASCULAR RISK IN NONDIABETIC SUBJECTS
    Silvi Ifrim, Constantin Ionescu-Tirgoviste, N. Paulescu · 2011
  89. 29. INSULIN AND BLOOD PRESSURE
    Academisch Ziekenhuis · 1996
  90. Insulin and Blood Pressure
    Rijk O. B. Gans, Ab J. M. Donker · 1996 · Springer eBooks
  91. Current View of the Pathogenesis of Arteriosclerosis in Diabetes Mellitus
    Ryoyu Takeda · 1991 · The Journal of Japan Atherosclerosis Society
  92. The effects of short-term low-carbohydrate and ketogenic interventions on cardiometabolic health
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  93. Désordres cliniques et biologiques associés
    2010 · Elsevier eBooks
  94. Désordres cliniques et biologiques associés
    2014 · Elsevier eBooks
  95. Hyperinsulinaemia as long-term predictor of death and ischaemic heart disease in nondiabetic men: The Malmo ¨ Preventive Project
    P. N Ilsson · 2003
  96. Hyperinsulinaemia as long-term predictor of death and ischaemic heart disease in nondiabetic men: The Malmo Preventive Project
    Jan-Åke, Hedblad · 2016
  97. Désordres cliniques et biologiques associés
    2019 · Elsevier eBooks
  98. Two Syndromes X
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