The relationships of concentrations of insulin, intact proinsulin and 32–33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge

Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works

Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats

Marella, S., Maddirela, D. R., Badri, K. R., Kumar, M. V. J., & Chippada, A. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373954 · Cited by 5,938 · see citing works

Quantitative Determination of Serum Triglycerides by the Use of Enzymes

Bucolo, G., & David, H. (1973) · Clinical Chemistry · doi:10.1093/clinchem/19.5.476 · Cited by 3,202 · see citing works

Insulin Resistance in Essential Hypertension

Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344 · see citing works

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909 · see citing works

Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study

Garcia, M. J., McNamara, P. M., Gordon, T., & Kannell, W. B. (1974) · Diabetes · doi:10.2337/diab.23.2.105 · Cited by 1,608 · see citing works

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474 · see citing works

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465 · see citing works

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

Hamsten, A., Wiman, B., Fairé, U. D., & Blombäck, M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132501 · Cited by 1,339 · see citing works

Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

Pyörälà, K. (1979) · Diabetes Care · doi:10.2337/diacare.2.2.131 · Cited by 775 · see citing works

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

Ducimetière, P., Eschwège, É., Papoz, L., Richard, J. L., Claude, J., & Rosselin, G. (1980) · Diabetologia · doi:10.1007/bf00275270 · Cited by 746 · see citing works

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

Welborn, T. A., & Wearne, K. L. (1979) · Diabetes Care · doi:10.2337/diacare.2.2.154 · Cited by 740 · see citing works

Enzymatic Determination of Total Cholesterol in Serum

Tarbutton, P. N., & Gunter, C. R. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.6.724 · Cited by 646 · see citing works

The effect of insulin on renal sodium metabolism

DeFronzo, R. A. (1981) · Diabetologia · doi:10.1007/bf00252649 · Cited by 641 · see citing works

Reappraisal of the role of insulin in hypertriglyceridemia

Olefsky, J. M., Farquhar, J. W., & Reaven, G. M. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90006-0 · Cited by 483 · see citing works

Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects

Vague, P., Juhan-Vague, I., Aillaud, M. F., Badier, C., Viard, R., Alessi, M., & Collen, D. (1986) · Metabolism · doi:10.1016/0026-0495(86)90209-x · Cited by 443 · see citing works

Diet, Obesity and Hypertension: An Hypothesis Involving Insulin, the Sympathetic Nervous System, and Adaptive Thermogenesis

LANDSBERG, L. (1986) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068066 · Cited by 373 · see citing works

Technical Report Series 930

(2006) · Technical Report Series 936 · doi:10.2471/trs.06.930 · Cited by 347 · see citing works

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

Verheijen, J. H., Chang, G. T. G., & Kluft, C. (1984) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1661109 · Cited by 340 · see citing works

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

Temple, R., Luzio, S. D., Schneider, A., Carrington, C. A., Owens, D. R., Sobey, W., & Hales, C. N. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91306-8 · Cited by 337 · see citing works

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

Sobey, W., Beer, S. F., Carrington, C. A., CLARK, P. M. S., Frank, B. H., Gray, I. P., Luzio, S. D., Owens, D. R., Schneider, A., Siddle, K., et al. (1989) · Biochemical Journal · doi:10.1042/bj2600535 · Cited by 335 · see citing works

Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease.

D, M. P. S. M., & Haffner, S. M. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.2.123 · Cited by 331 · see citing works

Insulin Stimulates the Synthesis of Plasminogen Activator Inhibitor 1 by the Human Hepatocellular Cell Line Hep G2

Alessi, M., Juhan-Vague, I., Kooistra, T., Declerck, P. J., & Collen, D. (1988) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646997 · Cited by 289 · see citing works

Diabetes, hyperinsulinaemia, and coronary risk factors in Bangladeshis in east London.

McKeigue, P., Marmot, M. G., Court, Y. D. S., Cottier, D., Rahman, S., & Riemersma, R. A. (1988) · Heart · doi:10.1136/hrt.60.5.390 · Cited by 278 · see citing works

Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

Ward, W. K., LaCava, E. C., Paquette, T. L., Beard, J. C., Wallum, B. J., & Porte, D. (1987) · Diabetologia · doi:10.1007/bf00296991 · Cited by 275 · see citing works

Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

Haffner, S. M., Fong, D. S., Hazuda, H. P., Pugh, J. A., & Patterson, J. K. (1988) · Metabolism · doi:10.1016/0026-0495(88)90133-3 · Cited by 254 · see citing works

Relationships between plasma insulin triglyceride, body mass index, and plasminogen activator inhibitor 1.

Juhan-Vague, I., Vague, P., Alessi, M., Badier, C., Valadier, J., Aillaud, M.-F., & Atlan, C. (1987) · PubMed · Cited by 218 · see citing works

PLASMA INSULIN AND LIPOPROTEIN CONCENTRATIONS: AN ATHEROGENIC ASSOCIATION?

Orchard, T. J., Becker, D. J., Bates, M. W., Kuller, L. H., & DRASH, A. L. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113639 · Cited by 187 · see citing works

Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin-dependent) diabetic patients and control subjects

Mohan, V., Sharp, P. S., Cloke, H. R., Burrin, J. M., Schumer, B., & KOHNER, E. M. (1986) · Diabetologia · doi:10.1007/bf00454882 · Cited by 181 · see citing works

Serum proinsulin levels at fasting and after oral glucose load in patients with Type 2 (non-insulin-dependent) diabetes mellitus

Yoshioka, N., Kuzuya, T., Matsuda, A., Taniguchi, M., & Iwamoto, Y. (1988) · Diabetologia · doi:10.1007/bf02341503 · Cited by 175 · see citing works

Blood pressure, insulin, and glycemia in nondiabetic subjects

Fournier, A. M., Gadia, M. T., Kubrusly, D. B., Skyler, J. S., & Sosenko, J. M. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90629-7 · Cited by 130 · see citing works

Is insulin the link between hypertension and obesity?

Christlieb, A. R., Krolewski, A. S., Warram, J. H., & Soeldner, J. S. (1985) · Hypertension · doi:10.1161/01.hyp.7.6_pt_2.ii54 · Cited by 128 · see citing works

Insulin Resistance in Patients of Asian Indian and European Origin with Non-Insulin Dependent Diabetes

Sharp, P., Mohan, V., Lévy, J., Mather, H. M., & KOHNER, E. M. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011745 · Cited by 127 · see citing works

The mechanism of insulin stimulation of (Na+,K+)-ATPase transport activity in muscle

Rosić, N. K., Standaert, M. L., & Pollet, R. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88958-x · Cited by 125 · see citing works

INHALATION DURING DENTAL ANESTHESIA.

Nh, P., PHILIPS, M., & Wf, W. (1964) · PubMed · Cited by 121 · see citing works

Relationship between blood pressure and plasma insulin in non-obese and obese non-diabetic subjects

Bonora, E., Zavaroni, I., Alpi, O., Pezzarossa, A., Bruschi, F., Dall’Aglio, E., Guerra, L., Coscelli, C., & BUTTURINI, U. (1987) · Diabetologia · doi:10.1007/bf00296995 · Cited by 113 · see citing works

RADIOIMMUNOASSAY MAY OVERESTIMATE INSULIN IN NON‐INSULIN‐DEPENDENT DIABETICS

Temple, R., CLARK, P. M. S., Nagi, D. K., Schneider, A., Yudkin, J. S., & Hales, C. N. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00915.x · Cited by 112 · see citing works

An enzymic assay for total serum cholesterol in the Vickers M-and D-300 Analyser.

Roeschlau, P., Bernt, E., & Gruber, W. (1974) · PubMed · Cited by 102 · see citing works

The Effects of Biosynthetic Human Proinsulin on Carbohydrate Metabolism

REVERS, R. R., Henry, R. R., Schmeiser, L., Kolterman, O., Cohen, R. M., Bergenstal, R. M., Polonsky, K. S., Jaspan, J. B., Rubenstein, A. H., Frank, B. H., et al. (1984) · Diabetes · doi:10.2337/diab.33.8.762 · Cited by 99 · see citing works

PLASMA INSULIN AND SERUM LIPIDS AND LIPOPROTEINS IN MIDDLE-AGED NON-INSULIN-DEPENDENT DIABETIC AND NON-DIABETIC SUBJECTS

Laakso, M., Pyörälà, K., Voutilainen, E., & Marniemi, J. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114574 · Cited by 96 · see citing works

Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats.

Peavy, D. E., Brunner, M., Duckworth, W. C., Hooker, C. S., & Frank, B. H. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38673-8 · Cited by 78 · see citing works

RELATIVE CONTRIBUTIONS OF INSULIN DEFICIENCY AND INSULIN RESISTANCE IN MATURITY-ONSET DIABETES

Turner, R. C., Holman, R. R., Matthews, D. R., & Peto, J. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91753-6 · Cited by 42 · see citing works

Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.

Halkin, H., Modan, M., Shefi, M., & Almog, S. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.71 · Cited by 40 · see citing works

2 Role of insulin resistance in the pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus

Gerich, J. E. (1988) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(88)80034-x · Cited by 25 · see citing works

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

Hales, C. N., & Barker, D. J. P. (1992) · Diabetologia · doi:10.1007/bf00400248 · Cited by 3,294 · see citing works

Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360 · see citing works

Small, Dense Low-Density Lipoprotein Particles as a Predictor of the Risk of Ischemic Heart Disease in Men: Prospective Results From the Que´bec Cardiovascular Study

Lamarche, B., Tchernof, A., Moorjani, S., Cantin, B., Dagenais, G. R., Lupien, P. J., & Despre´s, J.-P. (1997) · Circulation · doi:10.1161/01.cir.95.1.69 · Cited by 1,077 · see citing works

New Aspects of the Maillard Reaction in Foods and in the Human Body

Ledl, F., & Schleicher, E. D. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199005653 · Cited by 738 · see citing works

Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Diabetes Care · doi:10.2337/dc11-9998 · Cited by 718 · see citing works

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

Hales, C., & Barker, D. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt133 · Cited by 711 · see citing works

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

Juhan-Vague, I., Alessi, M., & Vague, P. (1991) · Diabetologia · doi:10.1007/bf00403280 · Cited by 566 · see citing works

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

Ferrannini, E. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.4.0336 · Cited by 451 · see citing works

PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events

Juhan-Vague, I., & Alessi, M. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657607 · Cited by 381 · see citing works

Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up

Fontbonne, A., Charles, M.-A. A., Thibult, N., Richard, J. L., Claude, J., Warnet, J., Rosselin, G., & Eschw�ge, E. (1991) · Diabetologia · doi:10.1007/bf00405009 · Cited by 377 · see citing works

Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians

Boucher, B. J., Mannan, N., Noonan, K., Hales, C. N., & Evans, S. J. W. (1995) · Diabetologia · doi:10.1007/bf00422375 · Cited by 365 · see citing works

The Adipocyte and Hemostatic Balance in Obesity

Loskutoff, D. J., & Samad, F. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.1 · Cited by 265 · see citing works

Relative Contribution of Insulin and Its Precursors to Fibrinogen and PAI-1 in a Large Population With Different States of Glucose Tolerance

Festa, A., Agostino, R. B. D., Mykkänen, L. M., Tracy, R. P., Zaccaro, D. J., Hales, C. N., & Haffner, S. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.562 · Cited by 262 · see citing works

Alcohol consumption and insulin concentrations. Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides.

Mayer, E. J., Newman, B. M., Quesenberry, C. P., FRIEDMAN, G. D., & Selby, J. V. (1993) · Circulation · doi:10.1161/01.cir.88.5.2190 · Cited by 193 · see citing works

Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes

Lehto, S., Rönnemaa, T., Pyörälà, K., & Laakso, M. (2000) · Diabetologia · doi:10.1007/s001250050023 · Cited by 192 · see citing works

Serum levels of insulin-like growth factor system components and relationship to bone metabolism in Type 1 and Type 2 diabetes mellitus patients

Jehle, P. M., Jehle, D. R., Mohan, S., & Böhm, B. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590297 · Cited by 193 · see citing works

Plasminogen Activator Inhibitor 1 and Atherothrombosis

Juhan-Vague, I., & Alessi, M. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646175 · Cited by 192 · see citing works

Endothelial function is impaired in fit young adults of low birth weight

Goodfellow, J. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00197-7 · Cited by 175 · see citing works

Die Maillard‐Reaktion in Lebensmitteln und im menschlichen Körper – neue Ergebnisse zu Chemie, Biochemie und Medizin

Ledl, F., & Schleicher, E. D. (1990) · Angewandte Chemie · doi:10.1002/ange.19901020604 · Cited by 161 · see citing works

Augmentation of the synthesis of plasminogen activator inhibitor type-1 by precursors of insulin. A potential risk factor for vascular disease.

Nordt, T., Schneider, D. J., & Sobel, B. E. (1994) · Circulation · doi:10.1161/01.cir.89.1.321 · Cited by 159 · see citing works

Insulin Resistance and Hypertension

Saad, M. F., Rewers, M., Selby, J. V., Howard, G., Jinagouda, S. D., Fahmi, S., Zaccaro, D., Bergman, R. N., Savage, P. J., & Haffner, S. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000128019.19363.f9 · Cited by 144 · see citing works

Thrombogenic and Fibrinolytic Factors and Cardiovascular Risk in Non-insulin-dependent Diabetes Mellitus

Juhan-Vague, I., Alessi, M., & Vague, P. (1996) · Annals of Medicine · doi:10.3109/07853899608999095 · Cited by 142 · see citing works

Fibrinolysis and thrombosis

Booth, N. A. (1999) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.1999.0034 · Cited by 131 · see citing works

Metabolic Precursors of Hypertension

Haffner, S. M. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440160106013 · Cited by 126 · see citing works

Proinsulin Is an Independent Predictor of Coronary Heart Disease

Zethelius, B., Byberg, L., Hales, C. N., Lithell, H., & Berne, C. (2002) · Circulation · doi:10.1161/01.cir.0000015855.04844.e7 · Cited by 121 · see citing works

Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: The Hoorn Study

Nijpels, G., Popp‐Snijders, C., Kostense, P. J., Bouter, L. M., & Heine, R. J. (1996) · Diabetologia · doi:10.1007/bf00400421 · Cited by 120 · see citing works

Stimulation by Proinsulin of Expression of Plasminogen Activator Inhibitor Type-I in Endothelial Cells

Schneider, D. J., Nordt, T. K., & Sobel, B. E. (1992) · Diabetes · doi:10.2337/diab.41.7.890 · Cited by 124 · see citing works

Effect of Troglitazone on Fibrinolysis and Activated Coagulation in Patients With Non–Insulin-Dependent Diabetes Mellitus

Fonseca, V. A., Reynolds, T., Hemphill, D., Randolph, C., Wall, J., Valiquett, T. R., Graveline, J. F., & Fink, L. M. (1998) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(97)00109-8 · Cited by 123 · see citing works

Metabolic Determinants Are Much More Important Than Genetic Polymorphisms in Determining the PAI-1 Activity and Antigen Plasma Concentrations

Henry, M., Trégouët, D., Alessi, M., Aillaud, M. F., Visvikis‐Siest, S., Siest, G., Tiret, L., & Juhan-Vague, I. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.84 · Cited by 121 · see citing works

Relationship between plasma plasminogen activator inhibitor-1 activity and VLDL triglyceride concentration, insulin levels and insulin sensitivity: studies in randomly selected normo- and hypertriglyceridaemic men

Asplund-Carlson, A., Hamsten, A., Wiman, B., & Carlson, L. A. (1993) · Diabetologia · doi:10.1007/bf00400356 · Cited by 120 · see citing works

Insulin Therapy in Type 2 Diabetic Subjects Suppresses Plasminogen Activator Inhibitor (PAI‐1) Activity and Proinsulin‐like Molecules Independently of Glycaemic Control

Jain, S. K., Nagi, D. K., Slavin, B. M., Lumb, P. J., & Yudkin, J. S. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb01992.x · Cited by 115 · see citing works

Carotid Artery Intima-Media Thickness in Elderly Patients With NIDDM and in Nondiabetic Subjects

NISKANEN, L. K., Rauramaa, R., Miettinen, H., Haffner, S. M., Mercuri, M. F., & Uusitupa, M. I. J. (1996) · Stroke · doi:10.1161/01.str.27.11.1986 · Cited by 113 · see citing works

Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin-dependent diabetic patients with and without hypertriglyceridaemia: the involvement of insulin, insulin precursor species and insulin resistance

Tan, K. C. B., Cooper, M. B., Ling, K. L. E., Griffin, B. A., Freeman, D. J., Packard, C. J., Shepherd, J., Hales, C. N., & Betteridge, D. J. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05454-q · Cited by 110 · see citing works

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic Beta cell

Halban, P. A. (1991) · Diabetologia · doi:10.1007/bf00408349 · Cited by 108 · see citing works

Hypertension, Insulin, and Proinsulin in Participants With Impaired Glucose Tolerance

The Diabetes Prevention Program Research Group (2002) · Hypertension · doi:10.1161/01.hyp.0000035706.28494.09 · Cited by 106 · see citing works

Plasminogen Activator Inhibitor-1 Activity Is Independently Related to Both Insulin Sensitivity and Serum Triglycerides in 70-Year-Old Men

Byberg, L., Siegbahn, A., Berglund, L., McKeigue, P., Reneland, R., & Lithell, H. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.2.258 · Cited by 105 · see citing works

The hemostatic system and coronary heart disease

Hamsten, A. (1993) · Thrombosis Research · doi:10.1016/0049-3848(93)90221-9 · Cited by 104 · see citing works

Insulin resistance: the shape of things to come

Williams, B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91904-6 · Cited by 103 · see citing works

Vascular Thrombosis in Type II Diabetes Mellitus

Colwell, J. A. (1993) · Diabetes · doi:10.2337/diab.42.1.8 · Cited by 102 · see citing works

Insulin resistance syndrome: interaction with coagulation and fibrinolysis

Köhler, H.-P. (2002) · Swiss Medical Weekly · doi:10.4414/smw.2002.09856 · Cited by 94 · see citing works

The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial

Myette‐Côté, É., Durrer, C. G., Neudorf, H., Bammert, T. D., Botezelli, J. D., Johnson, J. D., DeSouza, C. A., & Little, J. P. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00240.2018 · Cited by 100 · see citing works

Insulin Deficiency and Increased Plasma Concentration of Intact and 32/33 Split Proinsulin in Subjects with Impaired Glucose Tolerance

Davies, M. J., Rayman, G., Gray, I. P., Day, J., & Hales, C. N. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00071.x · Cited by 89 · see citing works

Proinsulin and Insulin Concentrations in Relation to Carotid Wall Thickness

Haffner, S. M., D’Agostino, R., Mykkänen, L. M., Hales, C. N., Savage, P. J., Bergman, R. N., O’Leary, D., Rewers, M., Selby, J. V., Tracy, R. P., et al. (1998) · Stroke · doi:10.1161/01.str.29.8.1498 · Cited by 83 · see citing works

Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome

Haffner, S. M., Mykkänen, L. M., Valdez, R. A., D, M. P. S. M., Holloway, D. L., Monterrosa, A., & Bowsher, R. R. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.6.7989488 · Cited by 86 · see citing works

A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects

Haffner, S. M., Mykk�nen, L., Robbins, D. C., Valdez, R., Miettinen, H., Howard, B. V., D, M. P. S. M., & Bowsher, R. R. (1995) · Diabetologia · doi:10.1007/bf00401766 · Cited by 86 · see citing works

Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredity

Kuhl, J., Hilding, A., �stenson, C. G., Grill, V., Efendić, S., & B�venholm, P. (2004) · Diabetologia · doi:10.1007/s00125-004-1614-1 · Cited by 85 · see citing works

Why is insulin not a risk factor for coronary heart disease?

Jarrett, R. J. (1994) · Diabetologia · doi:10.1007/bf00400952 · Cited by 84 · see citing works

Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study.

YARNELL, J. W. G., Sweetnam, P. M., Marks, V., Teale, J. D., & Bolton, C. (1994) · Heart · doi:10.1136/hrt.71.3.293 · Cited by 78 · see citing works

Insulin resistance and the metabolic syndrome—or the pitfalls of epidemiology

Yudkin, J. S. (2007) · Diabetologia · doi:10.1007/s00125-007-0711-3 · Cited by 75 · see citing works

Insulin‐like growth factor binding protein‐1 in NIDDM: relationship with the insulin resistance syndrome

Mohamed‐Ali, Pinkney, J. H., Panahloo, Cwyfan‐Hughes, Hollý, & Yudkin (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00647.x · Cited by 73 · see citing works

The insulin-like growth factor system in vascular smooth muscle: Interaction with insulin and growth factors

Arnqvist, H. J., Bornfeldt, K., Chen, Y., & Lindström, T. (1995) · Metabolism · doi:10.1016/0026-0495(95)90222-8 · Cited by 69 · see citing works

Does Insulin Resistance Unite the Separate Components of the Insulin Resistance Syndrome?

Donahue, R. P., Bean, J. A., Donahue, R. A. D., Goldberg, R. B., & Prineas, R. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2413 · Cited by 68 · see citing works

Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study

Kahn, S. E., Leonetti, D. L., Prigeon, R. L., Boyko, E. J., Bergstrom, R. W., & Fujimoto, W. Y. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7714116 · Cited by 68 · see citing works

The insulin resistance syndrome: the controversy is dead, long live the controversy!

D, M. P. S. M. (1994) · Diabetologia · doi:10.1007/bf00400955 · Cited by 68 · see citing works

Bupropion and Breastfeeding: A Case of a Possible Infant Seizure

Chaudron, L. H., & Schoenecker, C. J. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0622f · Cited by 67 · see citing works

Impaired fibrinolysis and risk of thromboembolism

Wiman, B., & Hamsten, A. (1991) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(91)90012-b · Cited by 66 · see citing works

Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma

Kao, P.-C., Taylor, R. L., & Service, F. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.8175958 · Cited by 65 · see citing works

Plasminogen activator inhibitor: a risk factor for myocardial infarction in diabetic patients.

Gray, R. P., Yudkin, J. S., & Patterson, D. (1993) · Heart · doi:10.1136/hrt.69.3.228 · Cited by 65 · see citing works

Insulin Deficiency Rather Than Hyperinsulinaemia in Newly Diagnosed Type 2 Diabetes Mellitus

Davies, M. J., Metcalfe, J., Gray, I. P., Day, J., & Hales, C. N. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00070.x · Cited by 62 · see citing works

Hyperinsulinemia, risk factors, and coronary heart disease. The Zutphen Elderly Study.

Feskens, E. J. M., & Kromhout, D. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1641 · Cited by 61 · see citing works

Fibrinolysis and atherosclerosis: An update

Hamsten, A., & Eriksson, P. O. (1994) · Fibrinolysis and Proteolysis · doi:10.1016/0268-9499(94)90723-4 · Cited by 55 · see citing works

Hyperinsulinaemia as long‐term predictor of death and ischaemic heart disease in nondiabetic men: The Malmö Preventive Project

Nilsson, P. M., Nilsson, J.-Å., Hedblad, B., Eriksson, K., & Berglund, G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01064.x · Cited by 50 · see citing works

Association of proinsulin-like molecules with lipids and fibrinogen in non-diabetic subjects ? evidence against a modulating role for insulin

Mohamed‐Ali, V., Gould, M., Gillies, S., Goubet, S., Yudkin, J. S., & Haines, A. (1995) · Diabetologia · doi:10.1007/bf00402183 · Cited by 50 · see citing works

Is insulin an independent risk factor for hypertension? The Paris Prospective Study

Fagot‐Campagna, A., Balkau, B., Simon, D., Ducimetière, P., & Eschwège, É. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.3.542 · Cited by 46 · see citing works

Fibrinolysis and risk of coronary artery disease

Juhan-Vague, I., & Alessi, M. (1996) · Fibrinolysis and Proteolysis · doi:10.1016/s0268-9499(96)80023-3 · Cited by 47 · see citing works

Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus

Inoue, I., Takahashi, K., Noji, S., Awata, T., Negishi, K., & Katayama, S. (1997) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(97)00045-4 · Cited by 45 · see citing works

Relative Hyperproinsulinemia as a Sign of Islet Dysfunction in Women with Impaired Glucose Tolerance1

Larsson, H., & Åhrén, B. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5717 · Cited by 43 · see citing works

Hyperinsulinaemia, Insulin Resistance, Microalbuminuria and the Risk of Coronary Heart Disease

Yudkin, J. S. (1996) · Annals of Medicine · doi:10.3109/07853899608999104 · Cited by 43 · see citing works

Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians

Evans, S. J. W., Boucher, B. J., Mannan, N., Noonan, K., & Hales, C. N. (1995) · Diabetologia · doi:10.1007/s001250050418 · Cited by 42 · see citing works

Diabetes and osteoporosis

Saller, A., Maggi, S., Romanato, G., Tonin, P., & Crepaldi, G. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03324857 · Cited by 41 · see citing works

Coronary heart disease in diabetes mellitus: three new risk factors and a unifying hypothesis

Yudkin, J. S. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00895.x · Cited by 41 · see citing works

Proinsulin-like molecules and plasminogen activator inhibitor type 1 (PAI-1) activity in diabetic and non-diabetic subjects with and without myocardial infarction

Gray, R. P. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06070-4 · Cited by 41 · see citing works

Hyperinsulinemia, hyperproinsulinemia and insulin resistance in the metabolic syndrome

Schrezenmeir, J. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01919311 · Cited by 40 · see citing works

Is Hyperinsulinaemia a Central Characteristic of a Chronic Cardiovascular Risk Factor Clustering Syndrome? Mixed Findings in Asian Indian, Creole and Chinese Mauritians

Zimmet, P., Collins, V. R., Dowse, G. K., Alberti, K. G. M. M., Tuomilehto, J. O., Knight, L. T., Gareeboo, H., Chitson, P., Fareed, D., & For the Mauritius Noncommunicable Disease Study Group (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00291.x · Cited by 40 · see citing works

Sex Differences in the Association Between Proinsulin and Intact Insulin With Coronary Heart Disease in Nondiabetic Older Adults

Oh, J. Y., Barrett-Connor, E. L., & Wedick, N. M. (2002) · Circulation · doi:10.1161/hc1102.105565 · Cited by 38 · see citing works

Metabolic and Clinical Characteristics of South Asians and Europeans in Coventry

Simmons, D. S., & Powell, M. J. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00159.x · Cited by 37 · see citing works

5 Fibrinolysis and atherosclerosis

Hamsten, A., & Eriksson, P. O. (1995) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(05)80272-0 · Cited by 36 · see citing works

Absence of clinically overt atherosclerotic vascular disease and adverse changes in cardiovascular risk factors in 70 patients with insulinoma

Leonetti, F., Iozzo, P., Giaccari, A., Sbraccia, P., Buongiorno, A. M., Tamburrano, G., & Andreani, D. (1993) · Journal of Endocrinological Investigation · doi:10.1007/bf03348949 · Cited by 35 · see citing works

Epidemiology of hypertension and insulin resistance syndrome

Haffner, S. M. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715011-00003 · Cited by 35 · see citing works

Circulating proinsulinlike molecules

Yudkin, J. S. (1993) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(93)90036-x · Cited by 35 · see citing works

Do High Proinsulin and C-Peptide Levels Play a Role in Autonomic Nervous Dysfunction?

Töyry, J. P., NISKANEN, L. K., Mäntysaari, M., Länsimies, E., Haffner, S. M., Miettinen, H., & Uusitupa, M. I. J. (1997) · Circulation · doi:10.1161/01.cir.96.4.1185 · Cited by 34 · see citing works

Hyperinsulinemia and hypofibrinolysis: Effects of short-term optimized glycemic control with continuous insulin infusion in type II diabetic patients

Lormeau, B., Aurousseau, M. H., Valensi, P. E., Pariès, J., & Attali, J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90281-x · Cited by 34 · see citing works

Fibrinolytic function and coronary risk

Juhan-Vague, I., Morange, P., & Alessi, M. (1999) · Current Cardiology Reports · doi:10.1007/s11886-999-0069-x · Cited by 33 · see citing works

The roles of insulin resistance, hyperinsulinemia, and thiazolidinediones in cardiovascular disease

Uwaifo, G. I., & Ratner, R. E. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.009 · Cited by 33 · see citing works

Different effects of acarbose and glibenclamide on proinsulin and insulin profiles in people with Type 2 diabetes

Markolf Hanefeld, E., Haffner, S. M., Menschikowski, M., Koehler, C., Temelkova-Kurktschiev, T. S., Wildbrett, J., & Fischer, S. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00347-3 · Cited by 31 · see citing works

The Fat Mouse: A Powerful Genetic Model to Study Hemostatic Gene Expression in Obesity/NIDDM

Loskutoff, D. J., Fujisawa, K., & Samad, F. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06322.x · Cited by 31 · see citing works

Glucose intolerance in thalassemia major is related to insulin resistance and hepatic dysfunction

Pappas, S., Donohue, S. M., Denver, A. E., Mohamed‐Ali, V., Goubet, S., & Yudkin, J. S. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90038-4 · Cited by 30 · see citing works

Cardiovascular Risk Factors and the Prediabetic Syndrome

Haffner, S. M. (1996) · Annals of Medicine · doi:10.3109/07853899608999094 · Cited by 29 · see citing works

Effect of insulin versus sulfonylurea therapy on cardiovascular risk factors and fibrinolysis in type II diabetes

Panahloo, A., Mohamed‐Ali, V., Andrés, C., Denver, A. E., & Yudkin, J. S. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90023-3 · Cited by 28 · see citing works

Cross-Sectional and Prospective Associations between Abdominal Adiposity and Proinsulin Concentration

Hanley, A. J., McKeown‐Eyssen, G., Harris, S. B., Hegele, R. A., Wolever, T. M. S., Kwan, J., & Zinman, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8139 · Cited by 27 · see citing works

Determinants of coronary vascular disease in patients with type ii diabetes mellitus and their therapeutic implications

Schneider, D. J., & Sobel, B. E. (1997) · Clinical Cardiology · doi:10.1002/clc.4960200506 · Cited by 27 · see citing works

Progress in clinical fibrinolysis

EMEIS, J. J., Verheijen, J. H., Ronday, H. K., de Maat, M. P. M., & Brakman, P. (1997) · Fibrinolysis and Proteolysis · doi:10.1016/s0268-9499(97)80098-7 · Cited by 26 · see citing works

Serum Insulin , Proinsulin and Proinsulin / Insulin Ratio in Type 2 Diabetic Patients : As an Index of β - Cell Function or Insulin Resistance

Kim, N. H., Kim, D. L., Choi, K. M., Baik, S. H., & Choi, D. S. (2000) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2000.15.3.195 · Cited by 25 · see citing works

Effect of Sulphonylurea Therapy on Plasma Insulin, Intact and 32/33 Split Proinsulin in Subjects with Type 2 Diabetes Mellitus

Davies, M. J., Metcalfe, J., Day, J., Grenfell, A., Hales, C. N., & Gray, I. P. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00274.x · Cited by 25 · see citing works

Hypertension and non-insulin dependent diabetes.

Yudkin, J. S. (1991) · BMJ · doi:10.1136/bmj.303.6805.730 · Cited by 23 · see citing works

Untitled work

(2000) · doi:10.1002/1520-7560(2000)9999:9999

Insulin and lipoprotein metabolism with special reference to the diabetic state

TOMKIN, G. H., & Owens, D. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100303 · Cited by 22 · see citing works

Síndrome X cardiovascular y disfunción endotelial

Vázquez‐Rey, E., & Kaski, J. C. (2003) · Revista Española de Cardiología · doi:10.1016/s0300-8932(03)76843-2 · Cited by 23 · see citing works

Difference in the influence of maternal and paternal NIDDM on pancreatic beta-cell activity and blood lipids in normoglycaemic non-diabetic adult offspring

Kasperska-Czyżyk, T., Jedynasty, K., Bowsher, R. R., Holloway, D. L., Stradowska, I., Stepień, K., Nowaczyk, R., Szymczak, W., & Czyźyk, A. (1996) · Diabetologia · doi:10.1007/s001250050517 · Cited by 21 · see citing works

Improved Beta Cell Function, with Reduction in Secretion of Intact and 32/33 Split Proinsulin, after Dietary Intervention in Subjects with Type 2 Diabetes Mellitus

Davies, M. J., Metcalfe, J., Day, J. L., Grenfell, A., Hales, C. N., & Gray, I. P. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00233.x · Cited by 21 · see citing works

Cardiovascular risk factors in Asian and Caucasian subjects with and without type 2 diabetes : studies using new highly specific assays for insulin, intact proinsulin and des 31,32 split proinsulin

Nagi, D. K. (1995) · UCL Discovery (University College London)

Dissimilar association of conventional immuno-reactive versus specific insulin with cardiovascular risk factors: a consequence of proinsulinaemia?

Grootenhuis, P. A., Mooy, J. M., Kostense, P. J., Popp‐Snijders, C., Bouter, L. M., & Heine, R. J. (1998) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(98)00030-8 · Cited by 1 · see citing works

Evaluation of two insulin assays in insulin resistance syndrome (syndrome X).

Haffner, S. M., Mykkänen, L. M., Valdez, R. A., & D, M. P. S. M. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.9.1430 · Cited by 14 · see citing works

Plasma proinsulin in recently diagnosed type 2 diabetes mellitus

Schmidli, R. S., Hagan, C., Scott, R. S., Livesey, J., & Forbes, L. V. (1993) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(93)90007-r · Cited by 5 · see citing works

The Relationship of Fasting Serum Radioimmune Insulin Levels to Incident Coronary Heart Disease in an Insulin-Treated Diabetic Cohort

Dandona, P., Chaudhuri, A., & Aljada, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1307 · Cited by 2 · see citing works