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Cited by 97Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesNeurotransmitter Receptor Influence on Behavior

Plasma levels of d-amphetamine in hyperactive children: Serial behavior and motor responses

Brown, Gerald L., Hunt, Robert D., Ebert, Michael H., Bunney, William E., Kopin, Irwin J.·1979·Psychopharmacology
DOI 10.1007/bf00427126
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Abstract

Amphetamine has been clearly documented to be an efficacious treatment for hyperactive children. The pharmacokinetics of amphetamine have been studied in adults, but not in children. Sixteen male children who scored greater than 2SD from norms on Factors I and IV of Conner's Teacher Rating Scale and who were not excluded for reasons to do with medical or psychiatric conditions, intelligence, or age, had a plasma d-amphetamine apparent elimination half-life of 6.8 +/- 0.5h. Peak plasma level occurred between 3 and 4h (62.7 +/- 3.8 and 65.9 +/- 3.6 ng/ml, respectively). Six of these children had a repeat study and there were no significant differences within subject in apparent elimination half-lives and attained peak blood levels. The variation in plasma levels was greater during absorption than during elimination. Both behavioral and motor activity responses as analyzed by differences between amphetamine and placebo days (by paired t-tests) indicate significant responses between hours 1--4; however, these responses do not correlate with plasma amphetamine levels; they occur during the absorption phase. The decreased response to later similar plasma levels of d-amphetamine may be related to depletion of catecholamine stores, to replacement by a 'false neurotransmitter' metabolite of amphetamine, or to alteration in receptor sensitivity.

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Crossref · 10.1007/bf00427126

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88 of 88 references verified0 citation errors · 0 not checkable

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  • There is a paucity of studies on the pharmacokinetic and behavioral time course of effects of low-dose amphetamine administration for ADHD.

    “In spite of the frequency of use of amphetamine-containing products for the treatment of ADHD, there is a surprising paucity of studies on the pharmacokinetic (PK) and behavioral time course of effects of low-dose amphetamine administration for ADHD (Brown et al., 1979(Brown et al., , 1980;;Pelham et al., 1999;Swanson et al., 1998).”

    From Analog Classroom Assessment of a Once-Daily Mixed Amphetamine Formulation, SLI381 (ADDERALL XR), in Children With ADHD (2003) · cites this paper as Brown et al., 1979

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Related

Authors
Brown, G. L., Hunt, R. D., Ebert, M. H., Bunney, W. E., & Kopin, I. J.
Affiliations
  • National Institutes of Health (US)
  • Yale University (US)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1979-01
Volume
62
Issue
2
Pages
133-140
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf00427126
OpenAlex
W2001735633
Cited by
97
References
88
Citations by year
2025: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2012: 3
FWCI
3.67
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
d-amphetamine, hyperactivity, children, plasma drug concentration, pharmacokinetics, elimination half-life, Cmax, behavioral responses, motor activity, catecholamine depletion, receptor sensitivity
MeSH terms
Child, Child, Preschool, Dextroamphetamine, Half-Life, Humans, Hyperkinesis, Male, Motor Activity, Psychiatric Status Rating Scales, Serial Learning, Time Factors

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