Comparison of effects of desipramine and amitriptyline on EEG sleep of depressed patients
Abstract
Despite their widespread use, there are few data concerning the effects of tricyclic antidepressants on EEG sleep in depression. The present study documented the effects of desipramine (DMI, n = 17) and amitriptyline (AT, n = 16) upon EEG sleep in hospitalized depressed patients as part of a double-blind protocol involving 28 days of active treatment. Compared to placebo, patients receiving DMI showed somewhat worsened sleep continuity, particularly after 1 week of administration when the dose was 150 mg/day. On the other hand, sleep architecture and REM measures showed a rapid suppression of REM sleep, and then partial tolerance for this effect was observed with continued administration of DMI for 3 weeks. DMI was a more potent suppressor of REM sleep, while AT was more sedative. Based on these differences in effects upon EEG sleep, a discriminant function was derived and resulted in a correct classification of 87.5% of AT cases and 76.5% of DMI cases. These results are discussed in terms of the differences in pharmacological profiles for uptake blockade and anticholinergic potency for these two compounds.
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Desipramine (50-250mg) was associated with more nocturnal waking, shorter sleep, and less efficient sleep than amitriptyline (50-150mg).
“In another study (Shipley et al., 1985), desipramine (50-250mg) was associated with more nocturnal waking, shorter sleep, and less efficient sleep than amitriptyline (50-150mg).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Shipley et al., 1985
Imipramine and desipramine have been associated with insomnia.
“Amitriptyline (Hindmarch et al., 2000), trimipramine (Sonntag et al., 1996), nortriptyline (Hammack et al., 2002), dothiepin (Blacker et al., 1988) and doxepin (Hajak et al., 2001) have all been associated with sedation, while imipramine (Volkers et al., 2002) and desipramine (Shipley et al., 1985) are less likely to be linked with sedation, but have been associated with insomnia; the evidence is”
From Antidepressants and their effect on sleep (2005) · cites this paper as Shipley et al., 1985
Imipramine and desipramine are less likely to be linked with sedation.
“Amitriptyline (Hindmarch et al., 2000), trimipramine (Sonntag et al., 1996), nortriptyline (Hammack et al., 2002), dothiepin (Blacker et al., 1988) and doxepin (Hajak et al., 2001) have all been associated with sedation, while imipramine (Volkers et al., 2002) and desipramine (Shipley et al., 1985) are less likely to be linked with sedation, but have been associated with insomnia; the evidence is”
From Antidepressants and their effect on sleep (2005) · cites this paper as Shipley et al., 1985
Greater disturbance, and less sleep, is reported with imipramine and desipramine.
“Greater disturbance, and less sleep, is reported with imipramine (Volkers et al., 2002) and desipramine (Shipley et al., 1985).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Shipley et al., 1985
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Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323 · see citing works
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Cassano, P., & Fava, M. (2004) · Annals of Clinical Psychiatry · doi:10.1080/10401230490281618 · Cited by 154 · see citing works
2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults - Brazilian Sleep Association
Drager, L. F., Assis, M., Bacelar, A. F. R., Poyares, D. L. R., Conway, S. G., Pires, G. N., de Azevedo, A. P., Carissimi, A., Eckeli, A. L., Pentagna, Á., et al. (2023) · Sleep Science · doi:10.1055/s-0043-1776281 · Cited by 25 · see citing works
Effects of Antidepressant Treatment on Sleep EEG in Depression
Armitage, R. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601001s01 · Cited by 18 · see citing works
- Authors
- Shipley, J. E., Kupfer, D. J., Griffin, S. J., Dealy, R. S., Coble, P. A., McEachran, A. B., Grochocinski, V. J., Ulrich, R., & Perel, J. M.
- Venue
- Psychopharmacology
- Published
- 1985-01
- Volume
- 85
- Issue
- 1
- Pages
- 14-22
- ISSN
- 0033-3158
- 1432-2072
- Cited by
- 55
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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