The histopathology of the pancreas in Type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
Open accessAbstract
A 25-year computerised survey of deaths in the United Kingdom among diabetic patients of 19 years of age and under was performed. Suitable pancreatic material was available in 119 out of the 498 identified patients. The duration of diabetes was known in 95 of the 119 patients. In 60 patients it had been present for less than 1 year. Insulitis was present in 47 of the 60 patients (78%) with recent onset disease, and was also found in 3 patients who had been treated for diabetes for between 1 and 6 years. In cases in which it was identified, insulitis affected 23% of islets containing insulin, but affected only 1% of islets which were insulin deficient, thus supporting the concept that insulitis represents an immunologically mediated destruction of insulin secreting B cells. Four patients appeared to have a different disease from classical Type 1 (insulin-dependent) diabetes in that there was no evidence of insulitis and all islets contained insulin. The age of onset of diabetes was eighteen months or less in these patients.
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Nearly 20% of insulin-containing islets, as opposed to only 1% of insulin-deficient islets, are inflamed (ie, insulitis).
“nearly 20% of insulin-containing islets, as opposed to only 1% of insulin-deficient islets, are inflamed (ie, insulitis),”
From Type 1 diabetes (2014) · cites this paper as [59]
The 'Islet pathology in recent onset Type 1 diabetes' section reports insulitis in 23% of insulin-containing islets and 1% of insulin-deficient islets, but only among cases where insulitis was present. The claim captures the contrast but omits that condition and describes 23% as 'nearly 20%.' (LLM, conf=0.84)
Experimental — accuracy not yet measuredMany pancreata have non-inflamed insulin-containing islets that seem to be normal.
“and many pancreata have non-inflamed insulin-containing islets that seem to be normal.58,59”
From Type 1 diabetes (2014) · cites this paper as [59]
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Foulis, A. K., & Stewart, J. A. (1984) · Diabetologia · doi:10.1007/bf00262221 · Cited by 233 · cited 4× · see citing works
“This finding was observed in a higher number of cases by Foulis and Stewart [5], and has been put beyond doubt in the present study, which shows that insulin containing islets are 23 times more likely to be affected by this lesion than insulin deficient islets (Table 1).”
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Type 1 diabetes: new perspectives on disease pathogenesis and treatment
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- Authors
- Foulis, A. K., Liddle, C. N., Farquharson, M. A., Richmond, J. A., & Weir, R. S.
- Affiliations
- Glasgow Royal Infirmary (GB)
- Venue
- Diabetologia
- Published
- 1986-05
- Volume
- 29
- Issue
- 5
- Pages
- 267-274
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2074381810
- Cited by
- 469
- References
- 1
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 11 · 2017: 15 · 2016: 17 · 2015: 24 · 2014: 18 · 2013: 9 · 2012: 14
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, insulitis, pancreatic histopathology, pancreatic islets, beta cell destruction, diabetes duration
- MeSH terms
- Adolescent, Adult, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, United Kingdom, Humans, Infant, Islets of Langerhans, Male, Time Factors
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