Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
Open accessAbstract
Type 1A diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration of the pancreatic islets of Langerhans. A major impediment to advances in understanding, preventing, and curing T1D has been the inability to "see" the disease initiate, progress, or regress, especially during the occult phase. Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis. Specifically, we visualized islet inflammation, manifest by microvascular changes and monocyte/macrophage recruitment and activation, using magnetic resonance imaging of magnetic nanoparticles (MNPs). As a proof of principle for this approach, imaging of infused ferumoxtran-10 nanoparticles permitted effective visualization of the pancreas and distinction of recent-onset diabetes patients from nondiabetic controls. The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis.
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Ferumoxtran-based USPIO imaging of insulitis allows early discrimination between diabetic and healthy individuals.
“This allows for early discrimination between diabetic and healthy individuals [178].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [178]
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- Authors
- Gaglia, J. L., Guimaraes, A. R., Harisinghani, M., Turvey, S. E., Jackson, R., Benoist, C., Mathis, D., & Weissleder, R.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2011-01-04
- Volume
- 121
- Issue
- 1
- Pages
- 442-445
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3007157
- OpenAlex
- W2067753785
- Cited by
- 209
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 16 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 19 · 2015: 26 · 2014: 17 · 2013: 20 · 2012: 22
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Cancer Research Institute
- Pfizer
- RSNA Research and Education Foundation
- Radiological Society of North America
- Harvard University
- Harvard Catalyst (UL1-RR025758, RR025758)
- Covis Pharma
- National Institutes of Health (5u54ca119349-05, P50-CA86355, U54-CA119349, CA119349, CA86355)
- U.S. Public Health Service (P01-A1-054904)
- National Heart, Lung, and Blood Institute (U01HL080731)
- National Cancer Institute (P50-CA-86355, U24CA092782, P50CA086355, U54 CA-119349)
- National Center for Research Resources (UL1RR025758)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- type 1A diabetes, insulitis, pancreatic islet inflammation, non-invasive imaging, magnetic nanoparticles, ferumoxtran-10, magnetic resonance imaging, monocyte/macrophage recruitment, microvascular changes, autoimmune disease
- MeSH terms
- Adolescent, Adult, Dextrans, Diabetes Mellitus, Type 1, Female, Humans, Inflammation, Islets of Langerhans, Macrophages, Magnetic Resonance Imaging, Male, Microcirculation, Monocytes, Case-Control Studies, Young Adult, Magnetite Nanoparticles
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