The DOI matches its Crossref record, with a small difference in title or year; 13 of the 13 references it cites were found in a registry or an index.
Embryotoxic effects of thalidomide derivatives on the non-human primateCallithrix jacchus: 3. Teratogenic potency of the EM 12 enantiomers
Abstract
The teratogenic potencies of the enantiomers of 2-(2,6-dioxopiperidine-3-yl)-phthalimidine ( = EM 12), a teratogenic thalidomide analogue, were investigated in Callithrix jacchus, a primate very sensitive to the teratogenic action of this thalidomide analogue. The results indicate that the S-(-)-form of EM 12 is clearly more teratogenic than the R-(+)-form. The interpretation of the studies designed to evaluate stereo-selective differences in the teratogenicity of the enantiomers becomes difficult, since both enantiomers racemise in vivo with appreciable rates (Schmahl et al. 1988a, b). Therefore, it cannot be concluded as yet that the R-(+)-form lacks all teratogenic potential.
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Species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity.
“Moreover, it has been shown that species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity (Butler, 1977; Heger et al., 1988; Ingalls et al., 1964; Vickers, 1967)”
From Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) · cites this paper as Heger et al., 1988
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Self-citationTeratologic studies on the Himalayan rabbit: new aspects of thalidomide-induced teratogenesis
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Research works printed but not linked: 2
- Jackson AJ, Schumacher HJ (1980) Identification of urinary metabolites of EM 12 N-2?,6?-dioxopiperidin-3?-yl)-phthalimidine, a teratogenic analogue of thalidomide in rats and rabbits. Can J Pharmaceut Sci 15: 21?23
- Schmahl HJ, Winckler K, Klinkm�ller K, Heger HW, Barrach HJ, Nau H (1987) Pharmacokinetics of the teratogenic and non-teratogenic thalidomide analogue EM 12 and supidimide in the rat and marmoset monkey. In: Nau H, Scott Jr WJ (eds) Pharmacokinetics in teratogenesis, Vol. I. Interspecies differences and placental transfer. CRC Press, Boca Raton, Florida, pp 181?192
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“Moreover, it has been shown that species such as mice, rats, and bush babies are resistant to thalidomide-induced teratogenicity (Butler, 1977; Heger et al., 1988; Ingalls et al., 1964; Vickers, 1967), which suggests an underlying genetic difference between species, more likely to be present in a…”
BackgroundEnantiomer specific pharmacokinetics
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Metadata
- Authors
- Heger, W., Klug, S., Schmahl, H.-J., Nau, H., Merker, H.-J., & Neubert, D.
- Affiliations
- Freie Universität Berlin (DE)
- Venue
- Archives of Toxicology
- Published
- 1988
- Volume
- 62
- Issue
- 2-3
- Pages
- 205-208
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W2887685628
- Cited by
- 30
- References
- 13
- Citations by year
- 2025: 1 · 2018: 2 · 2016: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Forschung und Technologie
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- thalidomide derivatives, teratogenicity, embryotoxicity, Callithrix jacchus, marmoset, enantiomers, stereoselectivity, racemization
- MeSH terms
- Abnormalities, Drug-Induced, Animals, Callithrix, Female, Pregnancy, Stereoisomerism, Thalidomide
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