The effects of thyroid hormones on3H-ouabain binding site concentration, Na, K-contents and86Rb-efflux in rat skeletal muscle
Abstract
Using a recently developed method based upon vanadate facilitated 3H-ouabain binding, the total concentration of 3H-ouabain binding sites was determined in biopsies of rat skeletal muscles containing varying proportions of slow-twitch fibres. In extensor digitorum longus, diaphragm, gastrocnemius and soleus muscles from mature (12-week-old) hyperthyroid rats the values obtained were respectively 2.6, 3.5, 5.1 and 9.8 times higher than those found in the same muscles from hypothyroid animals. This indicates that the effect of thyroid hormones is more pronounced on slow-twitch than on fast-twitch fibres. The changes in 3H-ouabain binding site concentration with thyroid status could not be accounted for by differences in affinity or the rate of 3H-ouabain binding. In young (4-5 week old) rats, where the K-content and the 3H-ouabain binding site concentration in muscle had been reduced by K-depletion, T3-pretreatment produced an even larger relative increase in the 3H-ouabain binding site concentration than in age-matched controls, but no increase in K-content. Therefore, the downregulation of 3H-ouabain binding sites seen during K-depletion cannot be attributed to a decreased response to thyroid hormones. In normal rats the marked stimulating effect of thyroid hormone on the synthesis of 3H-ouabain binding sites was not associated with any significant change in K-content, but clearly preceded by a significant (P less than 0.001) rise in the efflux of 86Rb.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The total intracellular potassium content measured in the diaphragm muscle of a thyrotoxic mouse is unchanged from the normal.
“It was seen that the total intracellular potassium content measured in the diaphragm muscle of a thyrotoxic mouse is unchanged from the normal [15].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [15]
Cites
The effect of catecholamines on Na—K transport and membrane potential in rat soleus muscle
Clausen, T., & Flatman, J. A. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011958 · Cited by 403 · see citing works
Self-citationThe Mechanism of the Calorigenic Action of Thyroid Hormone
Ismail‐Beigi, F., & Edelman, I. S. (1971) · The Journal of General Physiology · doi:10.1085/jgp.57.6.710 · Cited by 373 · see citing works
The effect of insulin on the transport of sodium and potassium in rat soleus muscle.
Clausen, T., & Kohn, P. G. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011703 · Cited by 228 · see citing works
Self-citationAsano, Y., Liberman, U. A., & Edelman, I. S. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108288 · Cited by 158 · see citing works
Lin, M. H., & Akera, T. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38162-0 · Cited by 157 · see citing works
Digoxin Metabolism in Hypo- and Hyperthyroidism
Doherty, J. E., & PERKINS, W. H. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-3-489 · Cited by 150 · see citing works
Evidence for a direct action of thyroid hormone in specifying muscle properties
Nwoye, L. O., Mommaerts, W. F. H. M., Simpson, D. R., Seraydarian, K., & Marusich, M. F. (1982) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1982.242.3.r401 · Cited by 150 · see citing works
EFFECT OF THYROID FUNCTION ON NUMBER OF Na-K PUMPS IN HUMAN SKELETAL MUSCLE
Kjeldsen, K. P., Gøtzsche, C.-O., Clausen, T., Nørgaard, A., & Thomassen, A. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91996-2 · Cited by 113 · see citing works
Self-citationNørgaard, A., Kjeldsen, K. P., Hansen, O., & Clausen, T. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(83)80154-5 · Cited by 109 · see citing works
Self-citationHansen, O., & Skou, J. C. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90254-x · Cited by 104 · see citing works
Biron, R. C., Burger, A., Chinet, A., Clausen, T., & Dubois‐Ferrière, R. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp013026 · Cited by 102 · see citing works
Self-citationThyrotoxicosis and Periodic Paralysis: Improvement with Beta Blockade
Conway, M. J., SEIBEL, J. A., & EATON, R. P. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-3-332 · Cited by 86 · see citing works
The age-dependent changes in the number of3H-ouabain binding sites in mammalian skeletal muscle
Kjeldsen, K. P., N�rgaard, A., & Clausen, T. (1984) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584838 · Cited by 69 · see citing works
Self-citationNicol, C. J. M., & Bruce, D. S. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582715 · Cited by 68 · see citing works
Nørgaard, A., Kjeldsen, K. P., & Hansen, O. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90131-7 · Cited by 66 · see citing works
Self-citationShishiba, Y., Shimizu, T., Saito, T., & Shizume, K. (1972) · Metabolism · doi:10.1016/0026-0495(72)90071-6 · Cited by 56 · see citing works
Capó, L. A., & Sillau, A. H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014835 · Cited by 55 · see citing works
Effect of K‐depletion on 3H‐ouabain binding and Na–K‐contents in mammalian skeletal muscle
Kjeldsen, K. P., Nørgaard, A., & Clausen, T. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb07488.x · Cited by 55 · see citing works
Self-citationCapasso, G., Lin, J., Santo, N. G. D., & Kinne, R. K.-H. (1985) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00583287 · Cited by 44 · see citing works
The effects of thyroid status on some properties of rat fast-twitch muscle
Nwoye, L. O., & Mommaerts, W. F. H. M. (1981) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf00713269 · Cited by 44 · see citing works
Haber, R. S., & Loeb, J. N. (1984) · Endocrinology · doi:10.1210/endo-115-1-291 · Cited by 43 · see citing works
Plasma and urinary digoxin in thyroid dysfunction
Shenfield, G. M., Thompson, J., & Horn, D. B. (1977) · European Journal of Clinical Pharmacology · doi:10.1007/bf00561063 · Cited by 37 · see citing works
Significance of skeletal muscle digitalis receptors for [3H]ouabain distribution in the guinea pig.
Kjeldsen, K. P., Nørgaard, A., Hansen, O., & Clausen, T. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23702-8 · Cited by 29 · see citing works
Self-citationEffects of ouabain, age and K-depletion on K-uptake in rat soleus muscle
Kjeldsen, K. P., N�rgaard, A., & Clausen, T. (1985) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585350 · Cited by 16 · see citing works
Self-citationChinet, A., & Clausen, T. (1984) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00583876 · Cited by 15 · see citing works
Self-citationHypokalaemic periodic paralysis complicating thyrotoxicosis.
Ali, K. (1975) · BMJ · doi:10.1136/bmj.4.5995.503-a · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Na + -K + Pump Regulation and Skeletal Muscle Contractility
Clausen, T. (2003) · Physiological Reviews · doi:10.1152/physrev.00011.2003 · Cited by 585 · see citing works
Self-citationDynamics and consequences of potassium shifts in skeletal muscle and heart during exercise.
Sejersted, O., & Sjøgaard, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1411 · Cited by 526 · see citing works
Regulation of the Na, K-pump in skeletal muscle
Clausen, T., & Everts, M. E. (1989) · Kidney International · doi:10.1038/ki.1989.1 · Cited by 237 · see citing works
Self-citationRelationship between glutamine concentration and protein synthesis in rat skeletal muscle
Jepson, M. M., BATES, P. C., Broadbent, P., Pell, J. M., & Millward, D. J. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.2.e166 · Cited by 204 · see citing works
Mechanism of Thyrotoxic Periodic Paralysis
Lin, S.-H., & Huang, C.-L. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010046 · Cited by 174 · see citing works
Biochemical principles of metabolic depression
Guppy, M., Fuery, C. J., & Flanigan, J. E. (1994) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(94)90001-9 · Cited by 165 · see citing works
Quantification of the maximum capacity for active sodium‐potassium transport in rat skeletal muscle.
Clausen, T., Everts, M. E., & Kjeldsen, K. P. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016608 · Cited by 114 · see citing works
Self-citationHorowitz, B., Hensley, C. B., Quintero, M., Azuma, K. K., Putnam, D., & McDonough, A. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77301-8 · Cited by 110 · see citing works
Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle
Kjeldsen, K. P., Richter, E. A., Galbo, H., Lortie, G., & Clausen, T. (1986) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(86)90570-5 · Cited by 91 · see citing works
Self-citationThyroidal regulation of rat renal and hepatic Na,K-ATPase gene expression.
GICK, G. G., Ismail‐Beigi, F., & Edelman, I. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37434-9 · Cited by 89 · see citing works
Thyrotoxic Periodic Paralysis: Clinical Challenges
Vijayakumar, A., Ashwath, G., & Thimmappa, D. (2014) · Journal of Thyroid Research · doi:10.1155/2014/649502 · Cited by 88 · see citing works
RetractedThompson, C. B., & McDonough, A. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32653 · Cited by 81 · see citing works
Wiig, H., Reed, R. K., & Tenstad, O. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.5.h1627 · Cited by 62 · see citing works
Muscle glutamine concentration and protein turnover in vivo in malnutrition and in endotoxemia
Millward, D. J., Jepson, M. M., & Omer, A. (1989) · Metabolism · doi:10.1016/0026-0495(89)90132-7 · Cited by 60 · see citing works
Everts, M. E., Retterstøl, K., & Clausen, T. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08479.x · Cited by 59 · see citing works
Self-citationChanges in K+, Na+ and calcium contents during in vivo stimulation of rat skeletal muscle
Everts, M. E., Lømo, T., & Clausen, T. (1993) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1993.tb09512.x · Cited by 57 · see citing works
Self-citationLavoie, L., Roy, D., Ramlal, T., Dombrowski, L., Martn-Vasallo, P., Marette, A., Carpentier, J. L., & Klip, A. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.5.c1421 · Cited by 49 · see citing works
Kjeldsen, K. P. (1986) · Biochemical Journal · doi:10.1042/bj2400725 · Cited by 48 · see citing works
Self-citationSweadner, K. J., McGrail, K. M., & Khaw, B. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48350-0 · Cited by 42 · see citing works
Correlation between magnesium and potassium contents in muscle: role of Na(+)-K+ pump
Dørup, I., & Clausen, T. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c457 · Cited by 41 · see citing works
Self-citationTime Course of Na,K Transport and Other Metabolic Responses to Thyroid Hormone in Clone 9 Cells*
Haber, R. S., Ismail‐Beigi, F., & Loeb, J. N. (1988) · Endocrinology · doi:10.1210/endo-123-1-238 · Cited by 40 · see citing works
Dauncey, M. J., & Burton, K. A. (1989) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584633 · Cited by 38 · see citing works
Amiodarone Inhibits the Na+-K+ Pump in Rabbit Cardiac Myocytes after Acute and Chronic Treatment
Gray, D. F., Mihailidou, A. S., HANSEN, P. S., Buhagiar, K. A., Bewick, N. L., Rasmussen, H., & Whalley, D. W. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37204-0 · Cited by 36 · see citing works
Brodie, C., & Sampson, S. R. (1988) · Endocrinology · doi:10.1210/endo-123-2-891 · Cited by 34 · see citing works
Harrison, A. P., Tivey, D. R., Clausen, T., Duchamp, C., & Dauncey, M. J. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960091 · Cited by 34 · see citing works
Self-citationEffects of thyroid hormone on Na+-K+ transport in resting and stimulated rat skeletal muscle
Everts, M. E., & Clausen, T. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.5.e604 · Cited by 34 · see citing works
Self-citationFlanigan, J. E., Withers, P. C., Fuery, C. J., & Guppy, M. (1993) · Journal of Comparative Physiology B · doi:10.1007/bf00302118 · Cited by 32 · see citing works
Thompson, C. B., Choi, C., Youn, J. H., & McDonough, A. A. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.6.c1411 · Cited by 31 · see citing works
Brodie, C., & Sampson, S. R. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041400116 · Cited by 31 · see citing works
Thyroxine induces transition of red towards white muscle in cultured heart cells
Brik, H., & Shainberg, A. (1990) · Basic Research in Cardiology · doi:10.1007/bf01907112 · Cited by 30 · see citing works
Kjeldsen, K. P., Everts, M. E., & Clausen, T. (1986) · British Journal Of Nutrition · doi:10.1079/bjn19860133 · Cited by 25 · see citing works
Self-citationSelective induction of high-ouabain-affinity isoform of Na+-K+-ATPase by thyroid hormone
Haber, R. S., & Loeb, J. N. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e912 · Cited by 22 · see citing works
Exercise-induced hyperkalemia in hypothyroid dogs
Schaafsma, I. A., van Emst, M. G., Kooistra, H. S., Verkleij, C. B., Peeters, M. E., de Boer, P., Rijnberk, A., & Everts, M. E. (2002) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(01)00130-8 · Cited by 21 · see citing works
Self-citationPhakdeekitcharoen, B., Phudhichareonrat, S., Pookarnjanamorakot, C., Kijkunasathian, C., Tubtong, N., Kittikanokrat, W., & Radinahamed, P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0552 · Cited by 18 · see citing works
Martus, G., Hofman-Bang, J., Clausen, T., Ølgaard, K., & Lewin, E. (2011) · Kidney International · doi:10.1038/ki.2010.501 · Cited by 18 · see citing works
Self-citationNa(+)-K+ pump in rat muscle: effects of hypophysectomy, growth hormone, and thyroid hormone
Everts, M. E., Dørup, I., Flyvbjerg, A., Marshall, S. M., & Jorgensen, K. D. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.2.e278 · Cited by 18 · see citing works
Self-citationNaik, S., Talwar, D., Acharya, S., Kumar, S., & Shrivastava, D. (2021) · Cureus · doi:10.7759/cureus.19566 · Cited by 17 · see citing works
Kjeldsen, K. P., & N�rgaard, A. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90273-5 · Cited by 16 · see citing works
Self-citationvan der Heide, S. M., Joosten, B. J. L. J., Everts, M. E., & Klaren, P. H. M. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810393 · Cited by 12 · see citing works
Self-citationHomogeneity of [3H]ouabain-binding sites in rat soleus muscle
Kjeldsen, K. P. (1988) · Biochemical Journal · doi:10.1042/bj2490481 · Cited by 11 · see citing works
Self-citationKennedy, D. G., Aronson, J. K., Bloomfield, J. G., & Smith, A. D. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90310-k · Cited by 9 · see citing works
Sharabani‐Yosef, O., Nir, U., & Sampson, S. R. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00423-3 · Cited by 8 · see citing works
Horie, I., Ando, T., Imaizumi, M., Usa, T., & Kawakami, A. (2015) · Endocrine Practice · doi:10.4158/ep14532.or · Cited by 6 · see citing works
Skeletal Muscle Changes in Hypothyroidism
Mantilla, C. B., Dow, D. E., & Sieck, G. C. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374135-6.00111-4 · Cited by 4 · see citing works
Sharabani‐Yosef, O., Bak, A., Nir, U., & Sampson, S. R. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1089 · Cited by 4 · see citing works
Felzen, B. (1989) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(89)90859-6 · Cited by 4 · see citing works
Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism
Schotanus, B. A., Meij, B. P., Vos, I. H. C., Kooistra, H. S., & Everts, M. E. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.08.004 · Cited by 3 · see citing works
Self-citationEverts, M. E. (2001) · Utrecht University Repository (Utrecht University) · Cited by 2 · see citing works
Self-citationGong, X. (2006) · Victoria University Research Repository (Victoria University) · Cited by 1 · see citing works
Potassium deficiency in rats: Effects on rates of dehydration and electrolyte homeostasis
Francesconi, R. P., Leva, N., Johnson, C. R., & Hubbard, R. W. (1994) · Journal of Thermal Biology · doi:10.1016/0306-4565(94)90060-4 · Cited by 1 · see citing works
Changes in resting membrane potential induced by active sensitization in the guinea-pig vas deferens
Noireaud, J., Souilem, O., Baudet, S., Bidon, J.-C., Gogny, M., & Jondet, A. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-7-8-802 · Cited by 1 · see citing works
Royal Academy of Medicine in Ireland Section of Biomedical Sciences
Ruddock, W., Burns, D., Brown, J. C., Allen, J. M., Hirst, D. G., Love, G. P., KEENAN, A. K., Lally, C., Bird, A., Ryan, M., et al. (1997) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf02943596 · Cited by 1 · see citing works
Royal academy of medicine in ireland section of biomedical sciences
Adderley, S., Fitzgerald, D. J., O'Neill, S. J., Fitzgerald, D. J., Moran, N., Smith, R., Fitzgerald, D. J., Stephens, G., Fitzgerald, D. J., Moran, N., et al. (1998) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf02937936 · Cited by 1 · see citing works
Royal academy of medicine in Ireland section of biomedical sciences
MacDermott, M., Doolan, C. M., KEENAN, A. K., Twomey, C. F., Doyle, M., Kirby, F., McDonald, N., McShane, A. J., Deasy, P. B., Boles, M. G., et al. (1993) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf02942170 · Cited by 1 · see citing works
Kjeldsen, K. P. (1994) · E&M. Endocrinology and metabolism · doi:10.1007/978-1-4612-2596-6_16
Self-citationNa+, K+-ATPase in single skeletal muscle fibres and the effects of ageing, training and inactivity
Wyckelsma, V. L. (2014) · Victoria University Research Repository (Victoria University)
- Authors
- Kjeldsen, K., Everts, M. E., & Clausen, T.
- Affiliations
- Aarhus University (DK)
- ORCID
- Clausen, Torben
- Venue
- Pfl�gers Archiv European Journal of Physiology
- Published
- 1986-05
- Volume
- 406
- Issue
- 5
- Pages
- 529-535
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- OpenAlex
- W1985537786
- Cited by
- 56
- References
- 26
- Citations by year
- 2021: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- thyroid hormones, ouabain binding sites, Na+/K+-ATPase, skeletal muscle, type I muscle fibers, fast-twitch fibres, hyperthyroidism, hypothyroidism, potassium content, potassium depletion, rubidium efflux, T3, extensor digitorum longus, diaphragm, gastrocnemius, soleus muscle
- MeSH terms
- Animals, Binding Sites, Female, Muscles, Osmolar Concentration, Ouabain, Potassium, Radioisotopes, Rats, Inbred Strains, Rubidium, Sodium, Thyroid Hormones, Tritium, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
