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Cited by 73

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Microbes, enzymes and genes involved in dichloromethane utilization

Leisinger, Thomas, Bader, Regula, Hermann, Ren�, Schmid-Appert, Monika, Vuilleumier, St�phane·1994·Biodegradation
DOI 10.1007/bf00696462
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Abstract

Dichloromethane (DCM) is efficiently utilized as a carbon and energy source by aerobic, Gram-negative, facultative methylotrophic bacteria. It also serves as a sole carbon and energy source for a nitrate-respiring Hyphomicrobium sp. and for a strictly anaerobic co-culture of a DCM-fermenting bacterium and an acetogen. The first step of DCM utilization by methylotrophs is catalyzed by DCM dehalogenase which, in a glutathione-dependent substitution reaction, forms inorganic chloride and S-chloromethyl glutathione. This unstable intermediate decomposes to glutathione, inorganic chloride and formaldehyde, a central metabolite of methylotrophic growth. Genetic studies on DCM utilization are beginning to shed some light on questions pertaining to the evolution of DCM dehalogenases and on the regulation of DCM dehalogenase expression. DCM dehalogenase belongs to the glutathione S-transferase supergene family. Analysis of the amino acid sequences of two bacterial DCM dehalogenases reveals 56% identity, and comparison of these sequences to those of glutathione S-transferases indicates a closer relationship to class Theta eukaryotic glutathione S-transferases than to a number of bacterial glutathione S-transferases whose sequences have recently become available. dcmA, the structural gene of the highly substrate-inducible DCM dehalogenase, is carried in most DCM utilizing methylotrophs on large plasmids. In Methylobacterium sp. DM4 its expression is governed by dcmR, a regulatory gene l…

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Crossref · 10.1007/bf00696462

Cites

59 of 59 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 10

  1. Bader R & Leisinger T (1993) Characterization ofdcmA inMethylophilus sp. DM11, the plasmid encoded structural gene of dichloromethane dehalogenase (Abstract). BioEngineering 9:58, P261
  2. Bader R (1994) Das Strukturgen der Dichlormethan Dehalogenase/Glutathion S-Transferase ausMethylophilus sp. Stamm DM11. Ph.D. Thesis. Federal Institute of Technology, Zürich
  3. Frank S (1993) Abbau von Dichlormethan durchHyphomicrobium DM2 unter denitrifizierenden Bedingungen. Diploma Thesis, Swiss Federal Institute of Technology, Zürich
  4. Gälli R, Stucki G & Leisinger T (1982) Mechanism of dehalogenation of dichloromethane by cell extract ofHyphomicrobium DM2. Experientia 38:1378
  5. Gonnet GH (1992) A tutorial introduction to Computational Biochemistry using Darwin. Institut für Wissenschaftliches Rechnen, ETH Zürich, Zürich, Switzerland
  6. Green PN (1993) Overview of the current state of methylotroph taxonomy. In: Murrell JC & Kelly DP (Eds) Microbial Growth on C1 Compounds (pp 253?265). Intercept Ltd, Andover, UK
  7. Leisinger T, La Roche S, Bader R, Schmid-Appert M, Braus-Stromeyer S & Cook AM (1993) Chlorinated methanes as carbon sources for aerobic and anaerobic bacteria. In: Murrell JC & Kelly DP (Eds) Microbial Growth on C1 Compounds (pp 351?363). Intercept Ltd, Andover, UK
  8. Pearson CR (1982) C1 and C2 halocarbons. In: Hutzinger O (Ed) The Handbook of Environmental Chemistry, Vol 3, Part B (pp 69?88). Springer Verlag, Berlin
  9. Sysoev OV, Govorukhina NI & Gruzman MB (1990) Glutathione S-transferase of methylotrophic bacteria: distribution and characterization. Appl. Biochem. Microbiol. 26:367?371
  10. Wever R (1993) Sources and sinks of halogenated methanes in nature. In: Murrell JC & Kelly DP (Eds) Microbial Growth on C1 Compounds (pp 35?45). Intercept Ltd, Andover, UK

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Metadata

Authors
Leisinger, T., Bader, R., Hermann, R., Schmid-Appert, M., & Vuilleumier, S.
Venue
Biodegradation
Publisher
Springer Science and Business Media LLC
Published
1994-12
Volume
5
Issue
3-4
Pages
237-248
ISSN
  • 0923-9820
  • 1572-9729
DOI
10.1007/bf00696462
Cited by
73
References
59
Language
en
Licence
www.springer.com/tdm (tdm)

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