The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Sequence determination of the 3’ end of mouse mammary tumor virus RNA
Abstract
70S RNA has been prepared from mouse mammary tumor virus (MMTV) produced by the GR tumor cell line. After denaturation for 3 min at 60 degrees C the RNA was applied to a sucrose gradient and molecules sedimenting between 10-16S were selected and passed over an oligo-dT cellulose column. The poly A containing RNA fraction was used as a template for the synthesis of complementary DNA with reverse transcriptase in the presence of dideoxynucleoside triphosphates. Oligo-nucleotides p(dT)7rG, p(dT)7rA and (p(dT)7rC were tested for their primer activity. Two of the three primers gave readable sequences. This suggests a heterogeneity in the 3' end of the viral RNA, a phenomenon also observed with avian retroviruses. Nucleotides 37-45 from the 3' end are made up of only A's and T's and resemble a Hogness box. This finding could have biological consequences for the transcription of proviral DNA in the unintegrated and integrated state. Instead of the usual AAUAAA sequence present in mRNA's close and in front of the site of polyadenylation we find a sequence AGUAAA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is worth mentioning that in the case of MMTV, instead of the conserved hexamer AAUAAA, an alternative AGUAAA hexamer is located ∼20 nts upstream of the transcriptional start site, serving as the polyA signal (Klemenz et al. 1981, Coffin 1997).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Klemenz et al. 1981
Citations
Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
3′ Non-coding region sequences in eukaryotic messenger RNA
Proudfoot, N. J., & Brownlee, G. G. (1976) · Nature · doi:10.1038/263211a0 · Cited by 2,931
Nandi, S., & McGrath, C. M. (1973) · Advances in cancer research · doi:10.1016/s0065-230x(08)60535-7 · Cited by 330
Hagenbüchle, O., Bovey, R., & Young, R. A. (1980) · Cell · doi:10.1016/0092-8674(80)90125-7 · Cited by 242
Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding
Cohen, J., & VARMUS, H. E. (1979) · Nature · doi:10.1038/278418a0 · Cited by 207
Cohen, J., Shank, P. R., Morris, V. L., Cardiff, R. D., & VARMUS, H. E. (1979) · Cell · doi:10.1016/0092-8674(79)90010-2 · Cited by 192
Shank, P. R., Cohen, J., VARMUS, H. E., Yamamoto, K., & RINGOLD, G. M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2112 · Cited by 144
Mammary Tumour Virus Specific Nucleotide Sequences in Mouse DNA
Varmus, H. E., Bishop, J. M., Nowinski, R. C., & Sarker, N. H. (1972) · Nature New Biology · doi:10.1038/newbio238189a0 · Cited by 129
Morris, V. L., Medeiros, E., RINGOLD, G. M., Bishop, J. M., & VARMUS, H. E. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90284-4 · Cited by 125
Host-virus interactions in murine mammary carcinogenesis
BENTVELZEN, P. A. J. (1974) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(74)90012-2 · Cited by 97
Research works printed but not linked: 2
- BentvelzenP. & HilgersJ., 1980. In: G.Klein (ed.) Viral Oncology, Raven Press, New York, pp. 311?356.
- BentvelzenP., 1974. Biochim. Biophys. Acta 355: 236?259.
Cited by
Sorted by citations
Patterns of Variant Polyadenylation Signal Usage in Human GenesPreprint
Beaudoing, E., Freier, S. M., Wyatt, J. R., Claverie, J., & Gautheret, D. (2000) · Genome Research · doi:10.1101/gr.10.7.1001 · Cited by 695
Moore, R., Dixon, M., Smith, R., Peters, G., & Dickson, C. (1987) · Journal of Virology · doi:10.1128/jvi.61.2.480-490.1987 · Cited by 256
Slaton, J. W., Inoue, K., Perrotte, P., El‐Naggar, A. K., Swanson, D. A., Fidler, I. J., & Dinney, C. P. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64016-3 · Cited by 193
Buetti, E., & Diggelmann, H. (1981) · Cell · doi:10.1016/0092-8674(81)90129-x · Cited by 161
Self-citationFasel, N. J., Pearson, K. W., Buetti, E., & Diggelmann, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01115.x · Cited by 145
Self-citation
Metadata
- Authors
- Klemenz, R., Reinhardt, M., & Diggelmann, H.
- Venue
- Molecular Biology Reports
- Published
- 1981
- Volume
- 7
- Issue
- 1-3
- Pages
- 123-126
- ISSN
- 0301-4851 (ISSN-L)
- 1573-4978
- OpenAlex
- W2060232992
- Cited by
- 24
- References
- 19
- Citations by year
- 2025: 1 · 2013: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Biology Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- mouse mammary tumor virus, RNA sequence determination, polyadenylation signal, RNA heterogeneity, retroviral RNA
- MeSH terms
- Animals, Base Sequence, Cell Line, Centrifugation, Density Gradient, DNA, Female, Hot Temperature, Mammary Tumor Virus, Mouse, Mammary Neoplasms, Experimental, Oligodeoxyribonucleotides, Poly A, RNA, RNA, Messenger, RNA, Viral, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sequence determination of the 3’ end of mouse mammary tumor virus RNA. https://app.cochat.ai/papers/10.1007/bf00778742
- The paper
- Klemenz, R., Reinhardt, M., & Diggelmann, H. (1981). Sequence determination of the 3’ end of mouse mammary tumor virus RNA. Molecular Biology Reports. https://doi.org/10.1007/bf00778742
