Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography
Open accessAbstract
This double-blind, placebo-controlled study assessed pharmacologically induced endogenous dopamine (DA) release in healthy male volunteers (n=12). Changes in endogenous DA release after injection of the psychostimulant drug methylphenidate were evaluated by single-photon emission tomography (SPET) and constant infusion of iodine-123 iodobenzamide ([123I]IBZM), a D2 receptor radioligand that is sensitive to endogenous DA release. Methylphenidate induced displacement of striatal [123I]IBZM binding, resulting in a significantly decrease in the specific to non-specific [123I]IBZM uptake ratio (average: 8.6%) in comparison with placebo (average: -1.9%). Moreover, injection of methylphenidate induced significant behavioural responses on the following items: excitement, anxiety, tension, and mannerisms and posturing. The results of this study demonstrate the feasibility of using constant infusion of [123I]IBZM and SPET imaging to measure endogenous DA release after methylphenidate challenge and to investigate neurochemical aspects of behaviour.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Methylphenidate increases striatal dopamine availability, as measured by reductions in ligand binding potential in PET studies.
“Methylphenidate has also been shown to increase striatal DA availability, as measured by reductions in ligand binding potential in PET studies (165, 166, 170, 178, 179, 181, 182, 187, 190, 191), with evidence to indicate that this effect is related to binding to the DAT (185, 186, 188).”
From The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities (2018) · cites this paper as [165]
The Results report that methylphenidate significantly reduced striatal radioligand uptake, and the Discussion reports a similar reduction in a human raclopride PET study. But this paper’s own measurement used [123I]IBZM single-photon emission tomography (SPET), not PET, so it does not itself provide the PET evidence implied by the citation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
No references could be resolved yet.
Research works printed but not linked: 11
- Volkov ND, Fowler JS, Gatley SJ, et al. PET evaluation of the dopamine system of the human brain. J Nucl Med 1996; 37: 1242-1256.
- Booij J, Tissingh G, Winogrodzka A, et al. Practical benefit of [ 123 I]FP-CIT SPET in the demonstration of the dopaminergic deficit in Parkinson's disease. Eur J Nucl Med 1997; 24: 68-71.
- Farde L, Nordström AL, Wiesel FA, Pauli S, Halldin C, Sedv- all G. Positron emission tomography analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch Gen Psychia- try 1992; 49: 538-544.
- Volkow ND, Wang G-J, Fowler JS, et al. Imaging endogenous dopamine competition with [ 11 C]raclopride in the human brain. Synapse 1994; 16: 255-262.
- Verhoeff NPLG, Kapucu O, Sokole-Busemann E, van Royen EA, Janssen AGM. Quantification of dopamine D2 receptor binding potential in the striatum with 123 I-IBZM SPECT: tech- nical and inter-observer variability. J Nucl Med 1993; 34: 2076-2084.
- Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. Cocaine recep- tors on dopamine transporters are related to self-administra- tion of cocaine. Science 1987; 237: 1219-1223.
- Wang G-J, Volkow ND, Fowler JS, et al. Methylphenidate de- creases regional cerebral blood flow in normal human sub- jects. Life Sci 1994; 54: 143-146. European Journal of Nuclear Medicine Vol. 24, No. 6, June 1997
- Laruelle M, Abi-Dargham A, van Dyck CH, et al. SPECT im- aging of striatal dopamine release after amphetamine chal- lenge. J Nucl Med 1995; 36: 1182-1190.
- Laruelle M, Abi-Dargham A, van Dyck CH, et al. Single pho- ton emission computerized tomography imaging of amphet- amine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 1996; 93: 9235-9240.
- Gatley SJ, Pan D, Chen R, Chaturvedi G, Ding Y-S. Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters. Life Sci 1996; 58: 231-239.
- Bobeldijk M, Verhoeff NPLG, Vekemans JAJM, et al. A sim- ple and high-yield synthesis of (S)-BZM, (R)-BZM, and (S)- IBZM for the preparation of (S)-123 I-IBZM. J Lab Comp Ra- diopharm 1990; 28: 1247-1256.
Cited by
Sorted by citations
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.-S., Gatley, S. J., Gifford, A., & Franceschi, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-j0001.2001 · Cited by 770 · see citing works
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
de Weijer, B. A., van de Giessen, E., van Amelsvoort, T. A., Boot, E., Braak, B., Janssen, I. M., van de Laar, A., Fliers, E., Serlie, M. J., & Booij, J. (2011) · EJNMMI Research · doi:10.1186/2191-219x-1-37 · Cited by 176 · see citing works
Self-citationDeep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder
Figee, M., de Koning, P., Klaassen, S., Vulink, N., Mantione, M., van den Munckhof, P., Schuurman, R., van Wingen, G., van Amelsvoort, T., Booij, J., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.021 · Cited by 112 · see citing works
Self-citationZijlstra, F., Booij, J., van den Brink, W., & Franken, I. H. A. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.11.002 · Cited by 109 · see citing works
Self-citationUdo de Haes, J. I., Kortekaas, R., Van Waarde, A., Maguire, R. P., Pruim, J., & den Boer, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0193-2 · Cited by 18 · see citing works
- Authors
- Booij, J., Korn, P., Linszen, D. H., & van Royen, E. A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- ORCID
- Booij, J.
- Venue
- European Journal of Nuclear Medicine
- Published
- 1997-06
- Volume
- 24
- Issue
- 6
- Pages
- 674-677
- ISSN
- 1619-7070 (ISSN-L)
- 0340-6997
- 1619-7089
- OpenAlex
- W2107173687
- Cited by
- 77
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 8 · 2013: 4 · 2012: 5
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
- handle.uba.uva.nl
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- endogenous dopamine release, [123I]IBZM, striatum, psychostimulants, behavioral responses
- MeSH terms
- Adult, Central Nervous System Stimulants, Behavior, Benzamides, Brain, Dopamine, Double-Blind Method, Humans, Iodine Radioisotopes, Male, Methylphenidate, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Dopamine Antagonists, Dopamine Uptake Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
