Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
Open accessAbstract
BACKGROUND: Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D2/D3 receptor [D2/3R] availability is lower in morbidly obese subjects. METHODS: To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [123I]IBZM SPECT, in 15 obese women and 15 non-obese controls. RESULTS: Striatal D2/3R availability was 23% (p = 0.028) lower in obese compared with non-obese women. CONCLUSION: This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obesity is associated with low D2 receptor binding, and morbidly obese individuals with the lowest D2 values had the largest body mass index, although one study did not find this.
“Obesity has been shown to be associated with low D2 receptor binding, and morbidly obese individuals with the lowest D2 values had the largest body mass index (de Weijer et al., 2011; Volkow et al., 2008; Wang et al., 2001), although this was not seen in one study (Steele et al., 2010).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as de Weijer et al., 2011
Preclinical and clinical studies provide evidence of decreases in striatal D2R that are linked with reward through the NAc and with habits and routines through the dorsal striatum in obesity.
“Both preclinical and clinical studies have provided evidence of decreases in striatal D2R, which, through the NAc, are linked with reward and through the dorsal striatum with the establishment of habits and routines in obesity (80–82).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [82]
Dysregulation of striatal D2R signaling has been implicated in obesity and compulsive food intake in obese rodents.
“Dysregulation of striatal D2R signaling has also been implicated in obesity (76,77) and in compulsive food intake in obese rodents (78).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
Reward, dopamine and the control of food intake: implications for obesity
Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400 · see citing works
Stice, E., Spoor, S., Bohon, C., & Small, D. M. (2008) · Science · doi:10.1126/science.1161550 · Cited by 786 · see citing works
Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K. G., & Hietala, J. A. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000350 · Cited by 672 · see citing works
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Thanos, P. K., Logan, J., Alexoff, D., Ding, Y.-S., Wong, C., Ma, Y., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.002 · Cited by 573 · see citing works
Volkow, N. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4099 · Cited by 514 · see citing works
D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
Noble, E. P. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10005 · Cited by 501 · see citing works
Booij, J., Tissingh, G., Boer, G. J., Speelman, J. D., Stoof, J. C., Janssen, A. G. M., Wolters, E. C., & van Royen, E. A. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.2.133 · Cited by 439 · see citing works
Self-citationAlterations of Central Dopamine Receptors Before and After Gastric Bypass Surgery
Steele, K. E., Prokopowicz, G. P., Schweitzer, M. A., Magunsuon, T. H., Lidor, A. O., Kuwabawa, H., Kumar, A., Brasic, J., & Wong, D. F. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0015-4 · Cited by 213 · see citing works
Rinne, J. O., Hietala, J. A., Ruotsalainen, U., Säkö, E., Laihinen, A., Någren, K., Lehikoinen, P., Oikonen, V., & Syvälahti, E. K. G. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.39 · Cited by 184 · see citing works
Decreased Dopamine Type 2 Receptor Availability After Bariatric Surgery: Preliminary Findings
Dunn, J. P., Cowan, R. L., Volkow, N. D., Feurer, I. D., Li, R., Williams, D. B., Kessler, R. M., & Abumrad, N. N. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.064 · Cited by 151 · see citing works
Effects of intravenous glucose on dopaminergic function in the human brain in vivo
Haltia, L. T., Rinne, J. O., Merisaari, H., Maguire, R. P., Savontaus, E., Helin, S., Någren, K., & Kaasinen, V. (2007) · Synapse · doi:10.1002/syn.20418 · Cited by 148 · see citing works
Influence of Methylphenidate on Eating in Obese Men
Leddy, J. J., Epstein, L. H., Jaroni, J. L., Roemmich, J. N., Paluch, R. A., Goldfield, G. S., & Lerman, C. E. (2004) · Obesity Research · doi:10.1038/oby.2004.29 · Cited by 104 · see citing works
Booij, J., Korn, P., Linszen, D. H., & van Royen, E. A. (1997) · European Journal of Nuclear Medicine · doi:10.1007/bf00841408 · Cited by 77 · see citing works
Self-citationBoot, E., Booij, J., Hasler, G., Zinkstok, J., de Haan, L., LINSZEN, D. H., & van Amelsvoort, T. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0739-8 · Cited by 46 · see citing works
Self-citationWang, G., Volkow, N. D., Fowler, J. S., et al. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00262-7 · Cited by 34 · see citing works
Striatal D 2 receptor binding in 22q11 deletion syndrome: an [ 123 I]IBZM SPECT study
Boot, E., Booij, J., Zinkstok, J., de Haan, L., LINSZEN, D. H., Baas, F., & van Amelsvoort, T. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109104854 · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The dopamine motive system: implications for drug and food addiction
Volkow, N. D., Wise, R. A., & Baler, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.130 · Cited by 939 · see citing works
Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800 · see citing works
The Addictive Dimensionality of Obesity
Volkow, N. D., Wang, G.-J., Tomasi, D., & Baler, R. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.020 · Cited by 380 · see citing works
The contribution of brain reward circuits to the obesity epidemic
Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.001 · Cited by 274 · see citing works
The role of reward circuitry and food addiction in the obesity epidemic: An update
Leigh, S.-J., & Morris, M. J. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2016.12.013 · Cited by 191 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Neural vulnerability factors that increase risk for future weight gain
Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Persistent effects of obesity: A neuroplasticity hypothesis
Matikainen‐Ankney, B. A., & Kravitz, A. V. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13665 · Cited by 56 · see citing works
Savage, S. W., Zald, D. H., Cowan, R. L., Volkow, N. D., Marks-Shulman, P. A., Kessler, R. M., Abumrad, N. N., & Dunn, J. P. (2014) · Obesity · doi:10.1002/oby.20690 · Cited by 27 · see citing works
- Authors
- de Weijer, B. A., van de Giessen, E., van Amelsvoort, T. A., Boot, E., Braak, B., Janssen, I. M., van de Laar, A., Fliers, E., Serlie, M. J., & Booij, J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Rijnstate Hospital (NL)
- Venue
- EJNMMI Research
- Published
- 2011
- Volume
- 1
- Issue
- 1
- Pages
- 37
- ISSN
- 2191-219X (ISSN-L)
- PMC
- PMC3265412
- OpenAlex
- W2109386189
- Cited by
- 176
- References
- 20
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 15 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 16 · 2016: 24 · 2015: 29 · 2014: 21 · 2013: 10 · 2012: 8
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- EJNMMI Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- obesity, receptor availability, dopaminergic reward system, food intake regulation, satiety, female obesity, replication study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
