Deferoxamine and aluminum clearance in pediatric hemodialysis patients
Abstract
Mobilization of aluminum by deferoxamine and the subsequent clearance from plasma by hemodialysis with or without charcoal hemofiltration was studied in four pediatric patients. Deferoxamine, 10-20 mg/kg, followed by dialysis with a Travenol CA50 dialyzer produced reductions in mean plasma aluminum levels from 2433 +/- 729 nmol/l (65.5 +/- 19.6 micrograms/l) to 1727 +/- 554 nmol/l (46.5 +/- 14.9 micrograms/l) during dialysis. The use of a charcoal cartridge in the circuit resulted in a reduction in mean plasma aluminum levels 2459 +/- 591 nmol/l (66.2 +/- 15.9 micrograms/ml) to 1380 +/- 106 nmol/l (35.8 +/- 2.9 micrograms/l). In one patient, high-flux dialysis produced a reduction from 2140 nmol/l (55.6 micrograms/l) to 1134 nmol/l (29.4 micrograms/l). No patients suffered direct adverse reactions to low-dose deferoxamine, although two patients had previously exhibited potential aluminum neurotoxicity after rapid increases in plasma aluminum levels with deferoxamine in higher doses. Aluminum levels must be monitored closely during deferoxamine therapy in uremic children to minimize the risk of exacerbating aluminum neurotoxicity.
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Deferoxamine has been used successfully to treat Al toxicity in children.
“It has also been used successfully to treat Al toxicity in children (Warady et al., 1986; Ogborn et al., 1991).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Ogborn et al., 1991
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Aluminium toxicosis: a review of toxic actions and effects
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- Authors
- Ogborn, M. R., Dorcas, V. C., & Crocker, J. F. S.
- Affiliations
- Health Sciences Centre (CA)
- Izaak Walton Killam Health Centre (CA)
- Venue
- Pediatric Nephrology
- Published
- 1991
- Volume
- 5
- Issue
- 1
- Pages
- 62-64
- ISSN
- 0931-041X (ISSN-L)
- 1432-198X
- OpenAlex
- W2045242387
- Cited by
- 8
- References
- 14
- Citations by year
- 2019: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- deferoxamine, pediatric hemodialysis, aluminum neurotoxicity, high-flux hemodialysis, iron chelation
- MeSH terms
- Aluminum, Charcoal, Child, Deferoxamine, Female, Renal Dialysis, Hemoperfusion, Humans, Male, Metabolic Clearance Rate
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