Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

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7. Determination of the Most Influential Sources of Variability in Tacrolimus Trough Blood Concentrations in Adult Liver Transplant Recipients: A Bottom-Up Approach
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8. Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore
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9. Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver
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14. Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations
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15. In vitro–in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: principles and applications
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22. Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes.
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27. Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: Studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver
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28. Comparative pharmacokinetics of benzodiazepines in dog and man
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29. Clearance Concepts: Fundamentals and Application to Pharmacokinetic Behavior of Drugs
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30. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio
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31. Cardiac Arrest and Therapeutic Hypothermia Decrease Isoform-Specific Cytochrome P450 Drug Metabolism
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32. Sequential first-pass elimination of a metabolite derived from a precursor
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33. Pharmacokinetic and Other Considerations for Drug Therapy During Targeted Temperature Management
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34. Safety testing of metabolites: Expectations and outcomes.
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36. Investigation of omeprazole and phenacetin first‐pass metabolism in humans using a microscale bioreactor and pharmacokinetic models
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37. Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics
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42. Development of a Whole Body Physiologically Based Model to Characterise the Pharmacokinetics of Benzodiazepines. 1: Estimation of Rat Tissue-Plasma Partition Ratios
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43. A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics
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44. Atypical Cytochrome P450 Kinetics
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45. A potential biomarker of isofenphos-methyl in humans: A chiral view.
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46. Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats.
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47. Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes
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48. Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance.
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49. Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: Characterization by the multiple indicator dilution technique
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50. Metabolic Switching of BILR 355 in the Presence of Ritonavir. II. Uncovering Novel Contributions by Gut Bacteria and Aldehyde Oxidase
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51. Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.
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52. Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling
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53. Physiologically Based Pharmacokinetics of Cyclosporine A: Reevaluation of Dose–Nonlinear Kinetics in Rats
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54. Comparison of the Hepatic Uptake Clearances of Fifteen Drugs with a Wide Range of Membrane Permeabilities in Isolated Rat Hepatocytes and Perfused Rat Livers
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56. Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs
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57. Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: The Traditional Model, Segregated Flow Model, and QGut Model
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58. Pharmacokinetics of haloperidol in psychotic patients
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65. Modeling of Hepatic Elimination and Organ Distribution Kinetics with the Extended Convection-Dispersion Model
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85. Development of PK- and PBPK-based modeling tools for derivation of biomonitoring guidance values
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86. THE EFFECT OF ANESTHESIA AND SURGERY ON CYP3A ACTIVITY IN RATS
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