Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice
Abstract
Exploratory behaviors as well as pharmacological actions of gamma-aminobutyric acidA (GABAA)/benzodiazepine receptor agonists and inverse agonists were characterized in C57BL/6J and A/J strains of mice. C57BL/6J mice displayed higher levels of exploratory behavior than A/J mice in the light in equilibrium with dark exploration model of anxiety and in an open-field test, suggesting that C57BL/6J mice are less "emotional" and more active than A/J mice, respectively. However, C57BL/6J mice were more sensitive than A/J mice to the anxiolytic effects of diazepam in the light in equilibrium with dark exploration model. In contrast, A/J mice were more sensitive than C57BL/6J mice to the convulsant effects of methyl-beta-carboline-3-carboxylate. C57BL/6J mice showed no evidence of acquisition of a passive avoidance task, while A/J readily acquired this memory task at low levels of footshock. C57BL/6J and A/J mice should be useful parental strains in recombinant inbred lines for investigating the genetic determinants of benzodiazepine-sensitive behaviors and sensitivity to drugs acting on the GABAA/benzodiazepine receptor complex.
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Alternatively, the A/J data may reflect low levels of open field exploratory behaviors and high levels of anxiety-like behaviors reported for A/J mice in other studies, and reflected in the low number of entries in the present study.
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
From Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004) · cites this paper as Mathis et al. 1994
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Self-citationGogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works
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MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776 · see citing works
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- Authors
- Mathis, C., Paul, S. M., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- Venue
- Behavior Genetics
- Published
- 1994-03
- Volume
- 24
- Issue
- 2
- Pages
- 171-180
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- OpenAlex
- W1991702917
- Cited by
- 111
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- benzodiazepine sensitivity, GABAA receptor, A/J mice, C57BL/6J mice, inbred mouse strains, anxiety, exploratory behavior, convulsant sensitivity, passive avoidance, footshock, recombinant inbred lines
- MeSH terms
- Animals, Arousal, Avoidance Learning, Carbolines, Convulsants, Diazepam, Exploratory Behavior, Female, Male, Mice, Inbred A, Mice, Inbred C57BL, Models, Genetic, Receptors, GABA-A, Seizures, Mice
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