Cited by 776Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains

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MOY, S, NADLER, J, YOUNG, N, PEREZ, A, HOLLOWAY, L, BARBARO, R, BARBARO, J, WILSON, L +2 more·2007·Behavioural Brain Research

Abstract

Three defining clinical symptoms of autism are aberrant reciprocal social interactions, deficits in social communication, and repetitive behaviors, including motor stereotypies and insistence on sameness. We developed a set of behavioral tasks designed to model components of these core symptoms in mice. Male mice from 10 inbred strains were characterized in assays for sociability, preference for social novelty, and reversal of the spatial location of the reinforcer in T-maze and Morris water maze tasks. Six strains, C57BL/6J, C57L/J, DBA/2J, FVB/NJ, C3H/HeJ, and AKR/J, showed significant levels of sociability, while A/J, BALB/cByJ, BTBR T(+)tf/J, and 129S1/SvImJ mice did not. C57BL/6J, C57L/J, DBA/2J, FVB/NJ, BALB/cByJ, and BTBR T(+)tf/J showed significant preference for social novelty, while C3H/HeJ, AKR/J, A/J, and 129S1/SvImJ did not. Normal scores on relevant control measures confirmed general health and physical abilities in all strains, ruling out artifactual explanations for social deficits. Elevated plus maze scores confirmed high anxiety-like behaviors in A/J, BALB/cByJ, and 129S1/SvImJ, which could underlie components of their low social approach. Strains that showed high levels of performance on acquisition of a T-maze task were also able to reach criterion for reversal learning. On the Morris water maze task, DBA/2J, AKR/J, BTBR T(+)tf/J, and 129S1/SvImJ failed to show significant quadrant preference during the reversal probe trial. These results highlight a dissociation between social task performance and reversal learning. BTBR T(+)tf/J is a particularly interesting strain, displaying both low social approach and resistance to change in routine on the water maze, consistent with an autism-like phenotype. Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses.

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Crossref · 10.1016/j.bbr.2006.07.030

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Authors
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
MOY, S
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2007-01-10
Volume
176
Issue
1
Pages
4-20
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2016411894
Cited by
776
References
144
Citations by year
2026: 17 · 2025: 21 · 2024: 26 · 2023: 25 · 2022: 41 · 2021: 43 · 2020: 51 · 2019: 46 · 2018: 43 · 2017: 38 · 2016: 52 · 2015: 50 · 2014: 58 · 2013: 43 · 2012: 54
FWCI
11.65
Type
journal article
Language
en
Open access
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • National Institutes of Health (5u54mh066418-05)
  • National Institute of Mental Health (U54-MH066418, U54 MH 66418)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30-HD03110, P30HD003110)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
autism spectrum disorder, inbred mouse strains, sociability, social novelty preference, reversal learning, Morris water maze, anxiety-like behavior, social communication deficits, repetitive behavior, mouse models of autism
MeSH terms
Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Genetics, Behavioral, Male, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred DBA, Mice, Inbred Strains, Motor Activity, Phenotype, Reversal Learning, Social Behavior, Species Specificity, Maze Learning, Mice

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