Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
Open accessAbstract
Three defining clinical symptoms of autism are aberrant reciprocal social interactions, deficits in social communication, and repetitive behaviors, including motor stereotypies and insistence on sameness. We developed a set of behavioral tasks designed to model components of these core symptoms in mice. Male mice from 10 inbred strains were characterized in assays for sociability, preference for social novelty, and reversal of the spatial location of the reinforcer in T-maze and Morris water maze tasks. Six strains, C57BL/6J, C57L/J, DBA/2J, FVB/NJ, C3H/HeJ, and AKR/J, showed significant levels of sociability, while A/J, BALB/cByJ, BTBR T(+)tf/J, and 129S1/SvImJ mice did not. C57BL/6J, C57L/J, DBA/2J, FVB/NJ, BALB/cByJ, and BTBR T(+)tf/J showed significant preference for social novelty, while C3H/HeJ, AKR/J, A/J, and 129S1/SvImJ did not. Normal scores on relevant control measures confirmed general health and physical abilities in all strains, ruling out artifactual explanations for social deficits. Elevated plus maze scores confirmed high anxiety-like behaviors in A/J, BALB/cByJ, and 129S1/SvImJ, which could underlie components of their low social approach. Strains that showed high levels of performance on acquisition of a T-maze task were also able to reach criterion for reversal learning. On the Morris water maze task, DBA/2J, AKR/J, BTBR T(+)tf/J, and 129S1/SvImJ failed to show significant quadrant preference during the reversal probe trial. These results highlight a dissociation between social task performance and reversal learning. BTBR T(+)tf/J is a particularly interesting strain, displaying both low social approach and resistance to change in routine on the water maze, consistent with an autism-like phenotype. Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses.
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Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders.
“Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders (59–70).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [61]
BTBR T+tf/J mice display behavioral phenotypes relevant to all three diagnostic symptoms of autism.
“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [61]
Cites
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works
The use of a plus-maze to measure anxiety in the mouse
Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617 · see citing works
A forkhead-domain gene is mutated in a severe speech and language disorder
Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha‐Khadem, F., & Monaco, A. P. (2001) · Nature · doi:10.1038/35097076 · Cited by 2,053 · see citing works
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · cited 7× · see citing works
“Data from the DBA and FVB strains were taken from a previously published dataset using identical methods [86], and included for comparison to the other inbred mouse strains.”
InfluentialSelf-citationGaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543 · see citing works
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372 · see citing works
Autistic Traits in the General Population: A Twin Study
Constantino, J. N., & Todd, R. D. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.524 · Cited by 1,317 · see citing works
Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223 · see citing works
Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Evidence of Brain Overgrowth in the First Year of Life in Autism
Courchesne, E. (2003) · JAMA · doi:10.1001/jama.290.3.337 · Cited by 1,120 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071 · see citing works
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931 · see citing works
(2000) · Cited by 919 · see citing works
Measuring normal and pathological anxiety-like behaviour in mice: a review
Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912 · see citing works
Uta Frith, A., & Mira, M. P. (1992) · Focus on Autism and Other Developmental Disabilities · doi:10.1177/108835769200700302 · Cited by 889 · see citing works
Broader autism phenotype: evidence from a family history study of multiple-incidence autism families
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.2.185 · Cited by 777 · see citing works
Automated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775 · see citing works
Self-citationGenetics of austim: complex aetiology for a heterogeneous disorder
Folstein, S. E., & Rosen-Sheidley, B. (2001) · Nature Reviews Genetics · doi:10.1038/35103559 · Cited by 771 · see citing works
Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 762 · see citing works
A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., et al. (2000) · Nature · doi:10.1038/35050103 · Cited by 740 · see citing works
Carola, V., D'Olimpio, F., Brunamonti, E., Mangia, F., & Renzi, P. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00452-1 · Cited by 735 · see citing works
Hazlett, H. C., Poe, M., Gerig, G., Smith, R. G., Provenzale, J., Ross, A., Gilmore, J., & Piven, J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1366 · Cited by 665 · see citing works
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616 · see citing works
(1994) · PubMed · Cited by 565 · see citing works
American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
(2012) · SpringerReference · doi:10.1007/springerreference_179660 · Cited by 527 · see citing works
MRI volumes of amygdala and hippocampus in non–mentally retarded autistic adolescents and adults
Aylward, E., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., & Pearlson, G. D. (1999) · Neurology · doi:10.1212/wnl.53.9.2145 · Cited by 513 · see citing works
Psychiatric endophenotypes and the development of valid animal models
Gould, T. D., & Gottesman, I. I. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00186.x · Cited by 507 · see citing works
Effects of age on brain volume and head circumference in autism
Aylward, E., Minshew, N. J., Field, K., Sparks, B. F., & Singh, N. (2002) · Neurology · doi:10.1212/wnl.59.2.175 · Cited by 496 · see citing works
Wong, S. T., Athos, J., Figueroa, X. A., Pineda, V. V., Schaefer, M. L., Chavkin, C. C., Muglia, L. J., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(01)80036-2 · Cited by 486 · see citing works
What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice
Crawley, J. N. (2007) · doi:10.1002/0470119055 · Cited by 474 · see citing works
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470 · see citing works
Defining the broader phenotype of autism: genetic, brain, and behavioral perspectives
DAWSON, G., WEBB, S., SCHELLENBERG, G. D., DAGER, S., FRIEDMAN, S., AYLWARD, E., & RICHARDS, T. (2002) · Development and Psychopathology · doi:10.1017/s0954579402003103 · Cited by 467 · see citing works
Localized enlargement of the frontal cortex in early autism
Carper, R. A., & Courchesne, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.005 · Cited by 456 · see citing works
Differences in fear motivated behaviors among inbred mouse strains
Trullás, R., & Skolnick, P. (1993) · Psychopharmacology · doi:10.1007/bf02244948 · Cited by 451 · see citing works
Factors controlling measures of anxiety and responses to novelty in the mouse
File, S. E. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00292-3 · Cited by 437 · see citing works
Griebel, G., Belzung, C., Perrault, G., & Sanger, D. J. (2000) · Psychopharmacology · doi:10.1007/s002130050038 · Cited by 420 · see citing works
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
Shu, W., Cho, J. Y., Jiang, Y., Zhang, M., Weisz, D. J., Elder, G. A., Schmeidler, J., Gasperi, R. D., Sosa, M. A. G., Rabidou, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503739102 · Cited by 415 · see citing works
Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits
MacDermot, K. D., Bonora, E., Sykes, N., Coupe, A., Lai, C. S. L., Vernes, S. C., Vargha‐Khadem, F., McKenzie, F., Smith, R. L., Monaco, A. P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/430841 · Cited by 411 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Regional brain enlargement in autism: a magnetic resonance imaging study.
Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199604000-00020 · Cited by 354 · see citing works
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Owen, E. H., Logue, S. F., Rasmussen, D. L., & Wehner, J. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00165-6 · Cited by 347 · see citing works
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
Moretti, P. M., Bouwknecht, J. A., Teague, R. M., Paylor, R. E., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi016 · Cited by 343 · see citing works
An MRI study of the corpus callosum in autism
Piven, J., Bailey, J. M., Ranson, B. J., & Arndt, S. V. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.8.1051 · Cited by 338 · see citing works
Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder
Persico, A. M., D'Agruma, L., Maiorano, N., Totaro, A., Militerni, R., Bravaccio, C., Wassink, T. H., Schneider, C., Melmed, R., Trillo, S., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000850 · Cited by 337 · see citing works
Association between a GABRB3 polymorphism and autism
Buxbaum, J. D., Silverman, J. M., Smith, C. J. W., Greenberg, D. A., Kilifarski, M., Reichert, J. G., Cook, E. H., Fang, Y., Song, C.-Y., & Vitale, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001011 · Cited by 322 · see citing works
Rogers, D. C., Jones, D. N. C., Nelson, P. R., Jones, C. M., Quilter, C. A., Robinson, T. L., & Hagan, J. J. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00072-8 · Cited by 294 · see citing works
Volkmar, F. R., & Pauls, D. L. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14471-6 · Cited by 288 · see citing works
Behavioural analysis of four mouse strains in an anxiety test battery
van Gaalen, M. M., & Steckler, T. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00240-0 · Cited by 267 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
Baron-Cohen, S. (2008) · doi:10.1093/oso/9780198504900.001.0001 · Cited by 253 · see citing works
An analysis of autism in fifty males with the fragile X syndrome
Hagerman, R. J., Jackson, A. W., Levitas, A., Rimland, B., Braden, M., Opitz, J. M., & Reynolds, J. F. (1986) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320230128 · Cited by 238 · see citing works
Gemelli, T., Berton, O., Nelson, E. D., Perrotti, L. I., Jaenisch, R., & Monteggia, L. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.025 · Cited by 237 · see citing works
Neuroanatomical substrates of social cognition dysfunction in autism.
Pelphrey, K., Adolphs, R., & Morris, J. P. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20040 · Cited by 233 · see citing works
Sankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.026 · Cited by 231 · see citing works
Epidemiological trends in rates of autism
Fombonne, E. J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001162 · Cited by 231 · see citing works
A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder
Waiter, G. D., Williams, J. H. G., Murray, A. D., Gilchrist, A., Perrett, D. I., & Whiten, A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.02.029 · Cited by 230 · see citing works
BALB/c mice: Low sociability and other phenotypes that may be relevant to autism
Brodkin, E. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.025 · Cited by 223 · see citing works
Toward a developmental neurobiology of autism
Polleux, F., & Lauder, J. M. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20044 · Cited by 216 · see citing works
Self-citationThe effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
Aggleton, J. P., Hunt, P. R., Nagle, S., & Neave, N. (1996) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)89080-2 · Cited by 211 · see citing works
Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains
Bouwknecht, J. A., & Paylor, R. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00200-0 · Cited by 209 · see citing works
Evidence supporting WNT2 as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Huang, J., Swiderski, R. E., Pietila, J., Braun, T. A., Beck, G. E., Folstein, S. E., Haines, J. L., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1401 · Cited by 206 · see citing works
Wahlsten, D., Metten, P., & Crabbe, J. C. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02354-0 · Cited by 206 · see citing works
Ho, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh212 · Cited by 201 · see citing works
A new continuous alternation task in T-maze detects hippocampal dysfunction in mice
Gerlai, R. T. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00214-3 · Cited by 195 · see citing works
An MRI study of autism: The cerebellum revisited
Courchesne, E., Piven, J., Saliba, K., Bailey, J. M., & Arndt, S. V. (1999) · Neurology · doi:10.1212/wnl.52.5.1106 · Cited by 192 · see citing works
Mapping Quantitative Trait Loci for Open-Field Behavior in Mice
Gershenfeld, H. K., Neumann, P. E., Mathis, C., Crawley, J. N., Li, X., & Paul, S. M. (1997) · Behavior Genetics · doi:10.1023/a:1025653812535 · Cited by 189 · see citing works
Effects of transgenic overproduction of CRH on anxiety‐like behaviour
van Gaalen, M. M., Stenzel‐Poore, M. P., Holsboer, F., & Steckler, T. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02040.x · Cited by 189 · see citing works
Waiter, G. D., Williams, J. H. G., Murray, A. D., Gilchrist, A., Perrett, D. I., & Whiten, A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.049 · Cited by 188 · see citing works
Social behavior deficits in the Fmr1 mutant mouse
Mineur, Y. S., Huynh, L. X., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.004 · Cited by 177 · see citing works
Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests
Brooks, S. P., Pask, T., Jones, L., & Dunnett, S. B. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00109.x · Cited by 177 · see citing works
Steiner, R. A., Hohmann, J. G., Holmes, A., Wrenn, C. C., Cadd, G., Juréus, A., Clifton, D. K., Luo, M., Gutshall, M., Ma, S. Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061445598 · Cited by 175 · see citing works
Saitoh, O. (2001) · Brain · doi:10.1093/brain/124.7.1317 · Cited by 175 · see citing works
An MRI Study of the Corpus Callosum and Cerebellum in Mentally Retarded Autistic Individuals
Manes, F. F., Piven, J., Vrancic, D., Nanclares-Nogués, V., Plebst, C., & STARKSTEIN, S. E. (1999) · Journal of Neuropsychiatry · doi:10.1176/jnp.11.4.470 · Cited by 172 · see citing works
Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001) · Journal of Child Neurology · doi:10.1177/088307380101600607 · Cited by 171 · see citing works
Social approach–avoidance behavior of inbred mouse strains towards DBA/2 mice
Brodkin, E. S., Hagemann, A., Nemetski, S. M., & Silver, L. M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.013 · Cited by 170 · see citing works
An MRI study of autism: The cerebellum revisited
Piven, J., Saliba, K., Bailey, J. M., & Arndt, S. V. (1997) · Neurology · doi:10.1212/wnl.49.2.546 · Cited by 163 · see citing works
Behavior and mutagenesis screens: The importance of baseline analysis of inbred strains
Tarantino, L. M., Gould, T. J., Druhan, J. P., & Bucan, M. (2000) · Mammalian Genome · doi:10.1007/s003350010107 · Cited by 158 · see citing works
Less white matter concentration in autism: 2D voxel-based morphometry
Chung, M. K., Dalton, K. M., Alexander, A. L., & Davidson, R. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.04.037 · Cited by 155 · see citing works
Link between emotional memory and anxiety states: A study by principal component analysis
Beuzen, A. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00013-9 · Cited by 152 · see citing works
Fatemi, S. H. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000129 · Cited by 151 · see citing works
Stress-induced disturbances in Morris water-maze performance: Interstrain variability
Francis, D. D. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00009-8 · Cited by 148 · see citing works
Dysferlin is a surface membrane–associated protein that is absent in Miyoshi myopathy
Matsuda, C., Aoki, M., Hayashi, Y. K., et al. (1999) · Neurology · doi:10.1212/wnl.53.5.1119 · Cited by 141 · see citing works
Peripheral Pulses of Oxytocin Increase Partner Preferences in Female, but Not Male, Prairie Voles
Cushing, B. S., & Carter, C. S. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1558 · Cited by 136 · see citing works
Mouse models of autism spectrum disorders: The challenge for behavioral genetics
Moy, S. S., Nadler, J. J., Magnuson, T., & Crawley, J. N. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30081 · Cited by 135 · see citing works
Self-citationTeaching old rats new tricks: age-related impairments in olfactory reversal learning
Schoenbaum, G. M., Nugent, S. L., Saddoris, M. P., & Gallagher, M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00343-8 · Cited by 132 · see citing works
Bothe, G. W. M., Bolivar, V. J., Vedder, M. J., & Geistfeld, J. G. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00064.x · Cited by 131 · see citing works
Molecular genetics and animal models in autistic disorder
Andres, C. R. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00642-6 · Cited by 121 · see citing works
Preference for social contact versus environmental enrichment in male laboratory mice
Van Loo, P. L. P., Van de Weerd, H. A., Van Zutphen, L. F. M., & Baumans, V. (2004) · Laboratory Animals · doi:10.1258/002367704322968867 · Cited by 118 · see citing works
The Neurobiological Context of Autism
Keller, F., & Persico, A. M. (2003) · Molecular Neurobiology · doi:10.1385/mn:28:1:1 · Cited by 114 · see citing works
Mathis, C., Paul, S. M., & Crawley, J. N. (1994) · Behavior Genetics · doi:10.1007/bf01067821 · Cited by 111 · see citing works
Bogue, M. A., & Grubb, S. C. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5057-2_8 · Cited by 109 · see citing works
Gonadal steroids influence the involvement of arginine vasopressin in social recognition in mice
Bluthé, R. M., Gheusi, G., & Dantzer, R. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90028-j · Cited by 107 · see citing works
Effect of Morris water maze diameter on visual-spatial learning in different mouse strains
Dam, D. V., LENDERS, G., & DEDEYN, P. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.09.006 · Cited by 103 · see citing works
Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice
Singer, J. B., Hill, A. E., Nadeau, J. H., & Lander, E. S. (2004) · Genetics · doi:10.1534/genetics.104.031492 · Cited by 100 · see citing works
Behavioral Phenotyping of Transgenic and Knockout Mice
Crawley, J. N. (1999) · CRC Press eBooks · doi:10.1201/9780849333644.pt3 · Cited by 100 · see citing works
Expanded characterization of the social interaction abnormalities in mice lacking Dvl1
Long, J. M., LaPorte, P., Paylor, R. E., & Wynshaw-Boris, A. J. (2004) · Genes Brain & Behavior · doi:10.1046/j.1601-183x.2003.00045.x · Cited by 98 · see citing works
Balogh, S. A., McDowell, C. S., Stavnezer, A. J., & Denenberg, V. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01586-3 · Cited by 93 · see citing works
Cook, M. N., Williams, R. W., & Flaherty, L. A. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.468 · Cited by 91 · see citing works
Mathis, C., Neumann, P. E., Gershenfeld, H. K., Paul, S. M., & Crawley, J. N. (1995) · Behavior Genetics · doi:10.1007/bf02327579 · Cited by 91 · see citing works
The search for autism disease genes
Wassink, T. H., Brzustowicz, L. M., Bartlett, C. W., & Szatmari, P. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20041 · Cited by 89 · see citing works
Striatal opioid peptide content in an animal model of spontaneous stereotypic behavior
PRESTI, M., & Lewis, M. H. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.08.003 · Cited by 83 · see citing works
Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task
Wahłsten, D., COOPER, S., & Crabbe, J. C. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.047 · Cited by 83 · see citing works
Learning and memory performance in mice lacking the GAL‐R1 subtype of galanin receptor
Wrenn, C. C., Kinney, J. W., Marriott, L. K., Holmes, A., Harris, A. P., Saavedra, M. C., Starosta, G., Innerfield, C. E., Jacoby, A. S., Shine, J., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03214.x · Cited by 82 · see citing works
Pharmacological Interventions in Autism: Theoretical and Practical Issues
Volkmar, F. R. (2001) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3001_9 · Cited by 79 · see citing works
Behavioural phenotyping of mouse mutants
van der Staay, F. J., & Steckler, T. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00278-9 · Cited by 78 · see citing works
Learning in inbred mice: Strain-specific abilities across three radial maze problems
Ammassari‐Teule, M., Hoffmann, H.-J., & Rossi‐Arnaud, C. (1993) · Behavior Genetics · doi:10.1007/bf01067443 · Cited by 78 · see citing works
Three autism candidate genes: a synthesis of human genetic analysis with other disciplines
Bartlett, C. W., Gharani, N., Millonig, J. H., & Brzustowicz, L. M. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.10.004 · Cited by 76 · see citing works
Subtypes of autism by cluster analysis based on structural MRI data
Hrdlička, M., Dudová, I., Beranova, I., Lisý, J., Belsan, T., Neuwirth, J., Komárek, V., Faladová, L., Havlovičová, M., Sedláček, Z., et al. (2005) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-005-0453-z · Cited by 67 · see citing works
Crawley, J. N. (2000) · ILAR Journal · doi:10.1093/ilar.41.3.136 · Cited by 67 · see citing works
Do Male Mice Prefer or Avoid Each Other’s Company? Influence of Hierarchy, Kinship, and Familiarity
Van Loo, P. L. P., de Groot, A. C., Van Zutphen, B. F. M., & Baumans, V. (2001) · Journal of Applied Animal Welfare Science · doi:10.1207/s15327604jaws0402_1 · Cited by 60 · see citing works
Familial symptom domains in monozygotic siblings with autism
Kolevzon, A., Smith, C. J., Schmeidler, J., Buxbaum, J. D., & Silverman, J. M. (2004) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30011 · Cited by 56 · see citing works
Oestreich, A. E. (2007) · Yearbook of Diagnostic Radiology · doi:10.1016/s0098-1672(08)70087-0 · Cited by 55 · see citing works
Disease susceptibility genes for autism
Bespalova, I., & Buxbaum, J. (2003) · Annals medicus · doi:10.1080/07853890310005966 · Cited by 52 · see citing works
Identifying interactions between genes and early environment in the mouse
Carola, V., Frazzetto, G., & Gross, C. T. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00152.x · Cited by 50 · see citing works
A question of balance: a proposal for new mouse models of autism
Murcia, C. L., Gulden, F. O., & Herrup, K. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.07.001 · Cited by 50 · see citing works
Rett syndrome: Of girls and mice—Lessons for regression in autism
Glaze, D. G. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20030 · Cited by 50 · see citing works
Johns, J. M., Noonan, L. R., ZIMMERMAN, L. I., McMillen, B. A., Means, L. W., Walker, C. H., Lubin, D. A., Meter, K. E., NELSON, C. J., Pedersen, C. A., et al. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09765.x · Cited by 50 · see citing works
Self-citationArolt, V., Lencer, R., Purmann, S., Sch�rmann, M., M�ller-Myhsok, B., Krecker, K., & SCHWINGER, E. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19991215)88:6 · Cited by 46 · see citing works
Crusio, W. E., Bertholet, J.-Y., & Schwegler, H. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90112-r · Cited by 39 · see citing works
Gendreau, P. L. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00131-0 · Cited by 38 · see citing works
Wahłsten, D. (1989) · Journal of Neurogenetics · doi:10.3109/01677068909167265 · Cited by 36 · see citing works
Mouse models for autism: report from a meeting
Insel, T. R. (2001) · Mammalian Genome · doi:10.1007/s00335-001-4006 · Cited by 33 · see citing works
Wahlsten, D., Crabbe, J., & Dudek, B. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00283-2 · Cited by 33 · see citing works
Heyser, C. J., McDonald, J. S., Polis, I. Y., & Gold, L. H. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.1.91 · Cited by 33 · see citing works
Sex-specific development of cortical monoamine levels in mouse
Connell, S., Karikari, C. A., & Höhmann, C. F. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.008 · Cited by 32 · see citing works
Thifault, S., Lalonde, R., Sanon, N., & Hamet, P. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00782-7 · Cited by 29 · see citing works
Gendreau, P. L., Petitto, J. M., Gariépy, J., & Lewis, M. H. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.2.424 · Cited by 25 · see citing works
Ono, T., Dean, R. G., Chattopadhyay, S. K., et al. (2009) · Gerontology · doi:10.1159/000212725 · Cited by 25 · see citing works
Gendreau, P. L., Petitto, J. M., Gariépy, J., & Lewis, M. H. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.2.424 · Cited by 23 · see citing works
Effects of Serotonin Depletion on the Play of Juvenile Rats
Knutson, B. D., & Panksepp, J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51942.x · Cited by 22 · see citing works
Behavioral phenotyping of transgenic and knockout animals: a cautionary tale.
Sd, B., & Nelson, R. J. (2001) · PubMed · Cited by 18 · see citing works
Autism and pervasive developmental disorders
Gadia, C. A., Tuchman, R. F., & Rotta, N. T. (2004) · Jornal de Pediatria · doi:10.2223/jped.1172 · Cited by 18 · see citing works
Long‐term potentiation in the hippocampus of fragile X knockout mice
Godfraind, J., Reyniers, E., Boulle, K. D., D’Hooge, R., Deyn, P. P. D., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Willems, P. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 16 · see citing works
Cook, M. N., Williams, R. W., & Flaherty, L. A. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.2.468 · Cited by 16 · see citing works
NELSON, C. J., McMILLEN, B. A., NOONAN, L. R., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/8fyp-h956 · Cited by 9 · see citing works
Mouse models for autism: report from a meeting
Insel, T. R. (2001) · Mammalian Genome · doi:10.1007/s00335-001-4006-6 · Cited by 3 · see citing works
Use of Pavlovian conditioning techniques to study disorders of attention and learning
Stanton, M. E., & Gallagher, M. (1996) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1996)2:4 · Cited by 2 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Rodent models in neuroscience research: is it a rat race?
Ellenbroek, B., & Youn, J. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.026120 · Cited by 627 · see citing works
Common circuit defect of excitatory-inhibitory balance in mouse models of autism
Gogolla, N., LeBlanc, J. J., Quast, K. B., Südhof, T. C., Fagiolini, M., & Hensch, T. K. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9023-x · Cited by 610 · see citing works
Automated Three‐Chambered Social Approach Task for Mice
Yang, M., Silverman, J. L., & Crawley, J. N. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0826s56 · Cited by 598 · see citing works
Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism
Scattoni, M. L., Gandhy, S. U., Ricceri, L., & Crawley, J. N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003067 · Cited by 550 · see citing works
Mouse Behavioral Assays Relevant to the Symptoms of Autism*
Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541 · see citing works
Silverman, J. L., Tolu, S. S., Barkan, C. L., & Crawley, J. N. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.201 · Cited by 438 · see citing works
Yang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6107-11.2012 · Cited by 369 · see citing works
Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364 · see citing works
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333 · see citing works
Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.98 · Cited by 288 · see citing works
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
Chadman, K. K., Gong, S., Scattoni, M. L., Boltuck, S. E., Gandhy, S. U., Heintz, N., & Crawley, J. N. (2008) · Autism Research · doi:10.1002/aur.22 · Cited by 292 · see citing works
Naviaux, J. C., Wang, L., Li, K., Bright, A., Alaynick, W. A., Williams, K. R., Powell, S. B., & Naviaux, R. K. (2015) · Molecular Autism · doi:10.1186/2040-2392-6-1 · Cited by 285 · see citing works
What's wrong with my mouse model?
Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology
Chen, J. A., Peñagarikano, O., Belgard, T. G., Swarup, V., & Geschwind, D. H. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040405 · Cited by 254 · see citing works
Wöhr, M., Orduz, D., Gregory, P., Moreno, H., Khan, U., Vörckel, K. J., Wolfer, D. P., Welzl, H., Gall, D., Schiffmann, S. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.19 · Cited by 258 · see citing works
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255 · see citing works
Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models
Orefice, L. L., Mosko, J. R., Morency, D. T., Wells, M. F., Tasnim, A., Mozeika, S. M., Ye, M., Chirila, A. M., Emanuel, A. J., Rankin, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.024 · Cited by 247 · see citing works
Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251 · see citing works
Social reward among juvenile mice
Panksepp, J. B., & Lahvis, G. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00295.x · Cited by 248 · see citing works
Social approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246 · see citing works
Self-citationWeissbrod, A., Shapiro, A., Vasserman, G., Edry, L., Dayan, M., Yitzhaky, A., Hertzberg, L., Feinerman, O., & Kimchi, T. (2013) · Nature Communications · doi:10.1038/ncomms3018 · Cited by 235 · see citing works
Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., et al. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.02.002 · Cited by 232 · see citing works
Self-citationHan, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231 · see citing works
Rodent empathy and affective neuroscience
Panksepp, J. B., & Lahvis, G. P. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.05.013 · Cited by 224 · see citing works
Sociability and motor functions in Shank1 mutant mice
Silverman, J. L., Turner, S. M., Barkan, C. L., Tolu, S. S., Saxena, R., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.026 · Cited by 218 · see citing works
The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies
Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S., & Crawley, J. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.66 · Cited by 215 · see citing works
Empathy is moderated by genetic background in mice
Chen, Q., Panksepp, J. B., & Lahvis, G. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004387 · Cited by 211 · see citing works
Development of a mouse test for repetitive, restricted behaviors: Relevance to autism
Moy, S. S., Nadler, J. J., Poe, M. D., Nonneman, R. J., Young, N. B., Koller, B. H., Crawley, J. N., Duncan, G. E., & Bodfish, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.029 · Cited by 195 · see citing works
Self-citationPeripheral and central inflammation in autism spectrum disorders
Depino, A. M. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.003 · Cited by 189 · see citing works
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality
Huang, T.-N., Chuang, H.-C., Chou, W.-H., Chen, C.-Y., Wang, H.-F., Chou, S.-J., & Hsueh, Y.-P. (2014) · Nature Neuroscience · doi:10.1038/nn.3626 · Cited by 180 · see citing works
Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works
Yin, F., Dumont, M., Banerjee, R., Ma, Y., Li, H., Lin, M. T., Beal, M. F., Nathan, C., Thomas, B., & Ding, A. (2010) · The FASEB Journal · doi:10.1096/fj.10-161471 · Cited by 180 · see citing works
Coretti, L., Cristiano, C., Florio, E., Scala, G., Lama, A., Keller, S., Cuomo, M., Russo, R., Pero, R., Paciello, O., et al. (2017) · Scientific Reports · doi:10.1038/srep45356 · Cited by 175 · see citing works
Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
Wöhr, M., Roullet, F. I., & Crawley, J. N. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00582.x · Cited by 169 · see citing works
Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism
Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00659.x · Cited by 171 · see citing works
Aberrant immune responses in a mouse with behavioral disorders
Heo, Y., Zhang, Y., Gao, D., Miller, V. M., & Lawrence, D. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020912 · Cited by 168 · see citing works
The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.021 · Cited by 147 · see citing works
Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146 · see citing works
Naviaux, J. C., Schuchbauer, M. A., Li, K., Wang, L., Risbrough, V. B., Powell, S. B., & Naviaux, R. K. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.33 · Cited by 134 · see citing works
Defensor, E. B., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.033 · Cited by 136 · see citing works
Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P., & Crawley, J. N. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.029 · Cited by 135 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Yang, M., Zhodzishsky, V., & Crawley, J. N. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.09.008 · Cited by 132 · see citing works
Ryan, B. C., Young, N. B., Crawley, J. N., Bodfish, J. W., & Moy, S. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.031 · Cited by 135 · see citing works
Self-citationDodero, L., Damiano, M., Galbusera, A., Bifone, A., Tsaftsaris, S. A., Scattoni, M. L., & Gozzi, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076655 · Cited by 116 · see citing works
Yang, M. (2007) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2007 · Cited by 124 · see citing works
Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117 · see citing works
He, L.-J., Liu, N., Cheng, T.-L., Chen, X.-J., Li, Y.-D., Shu, Y.-S., Qiu, Z.-L., & Zhang, X.-H. (2014) · Nature Communications · doi:10.1038/ncomms6036 · Cited by 107 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Low sociability in BTBR T+tf/J mice is independent of partner strain
Yang, M., Abrams, D. N., Zhang, J. Y., Weber, M. D., Katz, A. M., Clarke, A. M., Silverman, J. L., & Crawley, J. N. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.12.025 · Cited by 112 · see citing works
Sakurai, T., Dorr, N. P., Takahashi, N., McInnes, L. A., Elder, G. A., & Buxbaum, J. D. (2011) · Autism Research · doi:10.1002/aur.169 · Cited by 108 · see citing works
Social peers rescue autism‐relevant sociability deficits in adolescent mice
Yang, M., Perry, K., Weber, M. D., Katz, A. M., & Crawley, J. N. (2011) · Autism Research · doi:10.1002/aur.163 · Cited by 106 · see citing works
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders
Francis, S. M., Sagar, A., Levin-Decanini, T., Liu, W., Carter, C. S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.021 · Cited by 101 · see citing works
Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
Gantois, I., Pop, A. S., de Esch, C. E. F., Buijsen, R. A. M., Pooters, T., Gomez-Mancilla, B., Gasparini, F., Oostra, B. A., D’Hooge, R., & Willemsen, R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.059 · Cited by 100 · see citing works
Prosocial effects of oxytocin in two mouse models of autism spectrum disorders
Teng, B. L., Nonneman, R. J., Agster, K. L., Nikolova, V. D., Davis, T. T., Riddick, N. V., Baker, L. K., Pedersen, C. A., Jarstfer, M. B., & Moy, S. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.038 · Cited by 98 · see citing works
Self-citationPeartree, N. A., Hood, L. E., Thiel, K. J., Sanabria, F., Pentkowski, N. S., Chandler, K. N., & Neisewander, J. L. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.001 · Cited by 90 · see citing works
Impaired sociability and cognitive function in Nrcam-null mice
Moy, S. S., Nonneman, R. J., Young, N. B., Demyanenko, G. P., & Maness, P. F. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.021 · Cited by 84 · see citing works
Self-citationShpyleva, S., Ivanovsky, S., de Conti, A., Melnyk, S., Tryndyak, V., Beland, F. A., James, S. J., & Pogribny, I. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113712 · Cited by 83 · see citing works
Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors
Messer, A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.011 · Cited by 81 · see citing works
Inflammatory macrophage phenotype in BTBR T+tf/J mice
Onore, C. E., Careaga, M., Babineau, B. A., Schwartzer, J. J., Berman, R. F., & Ashwood, P. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00158 · Cited by 77 · see citing works
Inflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?
Careaga, M., Schwartzer, J., & Ashwood, P. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.006 · Cited by 77 · see citing works
Large neutral amino acid levels tune perinatal neuronal excitability and survival
Knaus, L. S., Basilico, B., Malzl, D., Gerykova Bujalkova, M., Smogavec, M., Schwarz, L. A., Gorkiewicz, S., Amberg, N., Pauler, F. M., Knittl-Frank, C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.037 · Cited by 70 · see citing works
Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T., & Brodkin, E. S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.025 · Cited by 69 · see citing works
Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice
Chang, Y.-C., Cole, T. B., & Costa, L. G. (2018) · Particle and Fibre Toxicology · doi:10.1186/s12989-018-0254-4 · Cited by 65 · see citing works
Blanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60 · see citing works
Serotonin neuron abnormalities in the BTBR mouse model of autism
Guo, Y., & Commons, K. G. (2017) · Autism Research · doi:10.1002/aur.1665 · Cited by 51 · see citing works
Tatsukawa, T., Ogiwara, I., Mazaki, E., Shimohata, A., & Yamakawa, K. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.009 · Cited by 47 · see citing works
Cope, E. C., Zych, A. D., Katchur, N. J., Waters, R. C., Laham, B. J., Diethorn, E. J., Park, C. Y., Meara, W. R., & Gould, E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01174-2 · Cited by 49 · see citing works
Smucny, J., Stevens, K. E., Olincy, A., & Tregellas, J. R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.77 · Cited by 28 · see citing works
Autism-related behavioral phenotypes in an inbred rat substrain
Zhang-James, Y., Yang, L., Middleton, F. A., Yang, L., Patak, J., & Faraone, S. V. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.035 · Cited by 26 · see citing works
McClintic, A. M., King, B. H., Webb, S. J., & Mourad, P. D. (2014) · Autism Research · doi:10.1002/aur.1349 · Cited by 25 · see citing works
Cholinergic transmission from the basal forebrain modulates social memory in male mice
Kljakic, O., Al‐Onaizi, M., Janíčková, H., Chen, K. S., Guzman, M. S., Prado, M. A. M., & Prado, V. F. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15400 · Cited by 22 · see citing works
- Authors
- MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- MOY, S
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-01-10
- Volume
- 176
- Issue
- 1
- Pages
- 4-20
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC1857288
- OpenAlex
- W2016411894
- Cited by
- 776
- References
- 144
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 26 · 2023: 25 · 2022: 41 · 2021: 43 · 2020: 51 · 2019: 46 · 2018: 43 · 2017: 38 · 2016: 52 · 2015: 50 · 2014: 58 · 2013: 43 · 2012: 54
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54-MH066418, U54 MH 66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30-HD03110, P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, inbred mouse strains, sociability, social novelty preference, reversal learning, Morris water maze, anxiety-like behavior, social communication deficits, repetitive behavior, mouse models of autism
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Genetics, Behavioral, Male, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred DBA, Mice, Inbred Strains, Motor Activity, Phenotype, Reversal Learning, Social Behavior, Species Specificity, Maze Learning, Mice
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