EEG dipole modeling in complex partial epilepsy

Ebersole, John S.

doi:10.1007/bf01132768

Cited by 134EEG and Brain-Computer InterfacesEpilepsy research and treatmentNeural dynamics and brain function

EEG dipole modeling in complex partial epilepsy

Ebersole, John S.·1991·Brain Topography

DOI 10.1007/bf01132768

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Abstract

Visual inspection and qualitative impressions of clinical EEG abnormalities are being replaced by quantitative characterization of scalp voltage fields and dipole modeling of underlying cerebral sources. Three approaches have been used in the analysis of focal spikes of complex partial epilepsy. 1) Instantaneous, single dipole, inverse solutions for the voltage topography of the spike peak have revealed two distinct equivalent dipole configurations in the brain lobe beneath the negative extreme-radial and oblique (mixed radial and tangential). Only radial dipoles have been found for frontal and fronto-central spikes, while either type have been found for temporal and occipital spike foci. 2) Dipole stability can be assessed by an inspection of sequential instantaneous solutions encompassing the spike complex or by calculating the standard deviation of dipole location (x,y,z) and orientation (elevation, azimuth) parameters during this period. Two-thirds of spike dipoles of the radial type and essentially all of the oblique equivalent dipoles were found to be stable, whereas one-third of the radial dipoles were unstable in position or orientation. 3) Spatio-temporal analysis can identify multiple underlying sources and their potentials. Modeling separate radial and tangential dipoles over the course of the spike has revealed a composite character for spike fields with oblique dipoles and often has defined leads or lags in activity that suggested propagation between infero-mesial and lateral temporal cortex. Correlations with clinical and intracranial EEG data suggest that patients with mesial temporal sclerosis have spikes with oblique and stable equivalent dipoles; patients with discrete cortical lesions have spikes with radial and stable dipoles; patients with extensive or multi-focal cortical insults have spikes with radial and unstable dipoles.

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Electrophysiological source imaging has been widely used in epilepsy source localization, including inter-ictal discharges.
“ESI has been widely used in epilepsy source localization, including inter-ictal discharges (76–81).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [76]

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Authors: Ebersole, J. S.
Affiliations: United States Department of Veterans Affairs (US)
Corresponding author: Ebersole, John S.
ORCID: Ebersole, John S.
Venue: Brain Topography
Publisher: Springer Science and Business Media LLC
Published: 1991
Volume: 4
Issue: 2
Pages: 113-123
ISSN: 0896-0267 (ISSN-L)
1573-6792
DOI: 10.1007/bf01132768
OpenAlex: W2089080762
Cited by: 132
References: 31
Citations by year: 2025: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2012: 4
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Brain Topography (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: complex partial epilepsy, focal spikes, spatio-temporal analysis, hippocampal sclerosis, temporal lobe epilepsy, spike propagation, cortical lesions
MeSH terms: Action Potentials, Brain, Brain Mapping, Electroencephalography, Humans, Models, Neurological, Epilepsy, Complex Partial

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EEG dipole modeling in complex partial epilepsy

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