Cited by 102Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingNeurotransmitter Receptor Influence on Behavior

Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain

Mogi, M., Harada, M., Kiuchi, K., Kojima, K., Kondo, T., Narabayashi, H., Rausch, D., Riederer, P. +2 more·1988·Journal of Neural Transmission

Abstract

Tyrosine hydroxylase (TH) contents in the caudate nucleus, putamen, and substantia nigra from control and parkinsonism brains were measured for the first time by a sandwich enzyme immunoassay. Both the TH protein content and TH activity (Vmax) were decreased in parallel in the parkinsonian brains as compared with those of the control brains. In contrast, TH "homospecific activity" (activity per enzyme protein) was significantly increased in the parkinsonian brains. The results indicate that the decrease of TH activity in parkinsonian brains is due to the decrease of TH protein content as a result of cell death. The increase in the "homospecific activity" of residual TH in parkinsonian brain suggests such molecular changes in TH molecules as result in a compensatory increase in TH activity.

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Crossref · 10.1007/bf01244634

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Authors
Mogi, M., Harada, M., Kiuchi, K., Kojima, K., Kondo, T., Narabayashi, H., Rausch, D., Riederer, P., Jellinger, K., & Nagatsu, T.
Affiliations
  • Matsumoto Dental University (JP)
  • Nagoya University (JP)
  • Food and Drug Safety Center (JP)
  • Juntendo University (JP)
  • University of Veterinary Medicine Vienna (AT)
  • University of Würzburg (DE)
Venue
Journal of Neural Transmission
Published
1988-02
Volume
72
Issue
1
Pages
77-82
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2013700933
Cited by
101
References
14
Citations by year
2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 16 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 1 · 2012: 1
FWCI
5.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
tyrosine hydroxylase, Parkinson's disease, enzyme protein content, caudate nucleus, putamen, substantia nigra, dopaminergic neuron loss
MeSH terms
Brain Chemistry, Caudate Nucleus, Corpus Striatum, Humans, Immunoenzyme Techniques, Parkinson Disease, Putamen, Substantia Nigra, Tyrosine 3-Monooxygenase

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