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Cited by 121Autoimmune and Inflammatory Disorders ResearchRheumatoid Arthritis Research and TherapiesOcular Diseases and Behçet’s Syndrome

Study of pro-inflammatory (TNF-?, IL-1?, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: Correlations with clinical and laboratory parameters

Kutukculer, N., Caglayan, S., Aydogdu, F.·1998·Clinical Rheumatology
DOI 10.1007/bf01451007
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Abstract

Acute phase proteins, synovial fluid (SF) cellular infiltrates, pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and Th1 (IL-2) and Th2 (IL-4) derived cytokine levels both in plasma and SF were examined in pauciarticular and polyarticular juvenile chronic arthritis (JCA) patients during the active (n = 22) and inactive (n = 14) period in order to determine pathogenic mechanisms and correlations between cytokines and laboratory parameters showing disease activity. The erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) and IgG concentrations were found to be significantly elevated in the active period of JCA. In pauciarticular JCA patients, when compared with their peripheral blood lymphocyte subpopulations, SF CD3+ cells (73.1%) and HLA-DR+ active T cells (22.5%) were found to be significantly increased. In the active period of JCA, plasma TNF-alpha and IL-6 concentrations were significantly elevated. Plasma IL-2 and IL-4 levels were not elevated and were found to be similar to those in the inactive phase and in healthy controls. SF IL-6, TNF-alpha and IL-1alpha levels were extremely high in all the patients. SF IL-4 and IL-2 levels were all undetectable. There was a significant correlation between ESR values and plasma IL-6 levels and between serum CRP levels and plasma IL-6 and TNF-alpha concentrations. In conclusion, increased local production of pro-inflammatory cytokines appears to account for the articular manifestations of JCA. The impaired production of anti-inflammatory Th2-derived cytokines (IL-4) seems to cause increased production of inflammatory cytokines acting on the balance between them. The deficit in IL-2 production was not suggested to be primarily involved in the pathogenesis. In addition, not only CRP and ESR values, but also plasma IL-6 and TNF-alpha concentrations may be used as markers of disease activity.

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  • In these patients, circulating concentrations of pro-inflammatory cytokines such as IL-1b and IL-6 are elevated.

    “In these patients, circulating concentrations of pro-inflammatory cytokines such as IL-1b and IL-6 are elevated (Kutukculer et al, 1998;Ji et al, 2002).”

    From Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency (2018) · cites this paper as Kutukculer et al, 1998

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Authors
Kutukculer, N., Caglayan, S., & Aydogdu, F.
Affiliations
Ege University (TR)
Venue
Clinical Rheumatology
Publisher
Springer Science and Business Media LLC
Published
1998-07
Volume
17
Issue
4
Pages
288-292
ISSN
  • 0770-3198 (ISSN-L)
  • 1434-9949
DOI
10.1007/bf01451007
OpenAlex
W2047262791
Cited by
121
References
26
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 10 · 2013: 5 · 2012: 10
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Clinical Rheumatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
juvenile idiopathic arthritis, synovial fluid cytokines, plasma cytokines, TNF-α, IL-1α, interleukin-6, interleukin-2, IL-4, Th1/Th2 balance, disease activity markers, C-reactive protein, erythrocyte sedimentation rate, HLA-DR+ T cells, pauciarticular arthritis, polyarthritis
MeSH terms
Adolescent, Arthritis, Juvenile, Blood Sedimentation, C-Reactive Protein, Child, Child, Preschool, Female, Humans, Immunoglobulin G, Interleukin-1, Interleukin-2, Male, Synovial Fluid, T-Lymphocytes, Tumor Necrosis Factor-alpha, Interleukin-4, Interleukin-6, Cytokines, Disease Progression

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