Cited by 81Protein Kinase Regulation and GTPase SignalingGenomic variations and chromosomal abnormalitiesNeurofibromatosis and Schwannoma Cases

Chromosomal localization of three humanras genes by in situ molecular hybridization

Popescu, N. C., Amsbaugh, S. C., DiPaolo, J. A., Tronick, S. R., Aaronson, S. A., Swan, D. C.·1985·Somatic Cell and Molecular Genetics

Abstract

Three human ras family protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras, have been mapped to chromosome bands 6p11-12, 12p11.1-12.1, and 1p11-13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of the possible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.

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Crossref · 10.1007/bf01534703

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Authors
Popescu, N. C., Amsbaugh, S. C., DiPaolo, J. A., Tronick, S. R., Aaronson, S. A., & Swan, D. C.
Affiliations
National Institutes of Health (US)
Venue
Somatic Cell and Molecular Genetics
Published
1985-03
Volume
11
Issue
2
Pages
149-155
ISSN
  • 0098-0366 (ISSN-L)
  • 0740-7750
  • 1572-9931
OpenAlex
W1994775044
Cited by
81
References
60
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Locations
  • Somatic Cell and Molecular Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Health Sciences › Medicine › Neurology › Neurofibromatosis and Schwannoma Cases
Keywords
ras gene, NRAS, proto-oncogenes, chromosomal localization, chromosome 6p, chromosome 12p, chromosome 1p
MeSH terms
Chromosome Mapping, Chromosomes, Human, 1-3, Chromosomes, Human, 6-12 and X, Cloning, Molecular, DNA, Humans, Lymphocytes, Neoplasms, Nucleic Acid Hybridization, Oncogenes

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