Chromosomal localization of three humanras genes by in situ molecular hybridization
Abstract
Three human ras family protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras, have been mapped to chromosome bands 6p11-12, 12p11.1-12.1, and 1p11-13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of the possible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.
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KRAS-2 gene is located on the short arm of chromosome 12 (12p11.1-12p12.1).
“KRAS-2 gene, located on the short arm of chromosome 12 (12p11.1-12p12.1) [14].”
From Drugging KRAS: Current perspectives and state-of-art review (2022) · cites this paper as [14]
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- Authors
- Popescu, N. C., Amsbaugh, S. C., DiPaolo, J. A., Tronick, S. R., Aaronson, S. A., & Swan, D. C.
- Affiliations
- National Institutes of Health (US)
- Venue
- Somatic Cell and Molecular Genetics
- Published
- 1985-03
- Volume
- 11
- Issue
- 2
- Pages
- 149-155
- ISSN
- 0098-0366 (ISSN-L)
- 0740-7750
- 1572-9931
- OpenAlex
- W1994775044
- Cited by
- 81
- References
- 60
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Somatic Cell and Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Health Sciences › Medicine › Neurology › Neurofibromatosis and Schwannoma Cases
- Keywords
- ras gene, NRAS, proto-oncogenes, chromosomal localization, chromosome 6p, chromosome 12p, chromosome 1p
- MeSH terms
- Chromosome Mapping, Chromosomes, Human, 1-3, Chromosomes, Human, 6-12 and X, Cloning, Molecular, DNA, Humans, Lymphocytes, Neoplasms, Nucleic Acid Hybridization, Oncogenes
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