The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Plasma neurotransmitters and cortisol in duodenal ulcer patients: Role of stress
Abstract
Levels of noradrenaline, adrenaline, dopamine, free serotonin, platelet serotonin, and cortisol were measured in the plasma of duodenal ulcer patients and controls. All subjects received antacids, and these substances were also measured. During relapse, all patients showed raised noradrenaline, adrenaline, dopamine, free serotonin, and cortisol values. In contrast, platelet serotonin showed very low values, which correlated negatively with all the former, except free serotonin. No correlations were found in parameters of the controls. After healing, significant reductions of noradrenaline, adrenaline, dopamine, free serotonin, and cortisol and significant increases of platelet serotonin values were observed. However, only dopamine, free serotonin, and cortisol reached normal values. Noradrenaline and adrenaline remained higher and platelet serotonin lower, both significantly more so than normals. These still-altered parameters showed similar correlations to those found during relapses. The present results demonstrate that some baseline autonomic system imbalance exists in patients, amplified and accentuated during relapse. We discuss the possibility that stress plays some role in triggering duodenal ulcer relapse.
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“In correlation with non-depressed individuals, depressed individuals have been found to have raised plasma catecholamine levels, including norepinephrine, epinephrine, and dopamine, high free-serotonin levels and low platelet-serotonin levels; [23-26]”
From A pilot study on the effects of exercise on depression symptoms using levels of neurotransmitters and EEG as markers (2014) · cites this paper as [25]
In the citing paper
“In correlation with non-depressed individuals, depressed individuals have been found to have raised plasma catecholamine levels, including norepinephrine, epinephrine, and dopamine, high free-serotonin levels and low platelet-serotonin levels; [23-26]”
From A pilot study on the effects of exercise on depression symptoms using levels of neurotransmitters and EEG as markers (2014) · cites this paper as [25]
In the citing paper
“Although this study was not able to replicate the degree of findings from previous studies examining catecholamine and 5HT levels, [20,21,25-28] this study did show a reduction in serum levels of catecholamine and 5HT levels within the exercise group; however, these decreases were not significant.”
From A pilot study on the effects of exercise on depression symptoms using levels of neurotransmitters and EEG as markers (2014) · cites this paper as [25]
Citations
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Research works printed but not linked: 5
- Lechin F, van der Dijs B, Azòcar J, Lechin AE, Gòmez F, Amat J, Lechin ME, Villa S, Bàez S, Acosta E, Cabrera A, Vitelli Florez G, Arocha L, Fernandez M, Mago E: Definite and sustained improvement with psychoactive drugs of three Crohn's disease patients: some neuroendocrinological, neurochemical and immunological findings. Abstract. Proceedings of the III Inter-American Congress of Clinical Pharmacology and Therapeutics. Arch Ven Farmac Terap 7:89, 1988
- Lechin F, van der Dijs B, Lechin-Bàez S, Vitelli-Florez G, Lechin ME, Cabrera A: Neurochemical, hormonal and immunological views of stress: Clinical and therapeutic implications in Crohn's disease and cancer.In Recent Advances in Pharmacology and Therapeutics: Proceedings of the III Inter-American Congress of Clinical Pharmacology and Therapeutics. M Velazco, A Israel, E. Romero, H Silva (eds). Amsterdam, Excerpta Medica, International Congress Series Vol. 839, 1989, pp 57?70
- Lechin ME, Villa S, Rada I, Jara H, Cabrera A, Jimènez V, van der Dijs B, Lechin F: Plasma neurotransmitters profile in reflux esophagitis. Abstract. Proceedings of the III Inter-American Congress of Clinical Pharmacology and Therapeutics. Arch Ven Farmac Terap 7:85, 1988
- Lechin F, van der Dijs B, Azòcar J, Amat J, Vitelli-Florez G, Martìnez C, Lechin S, Jimènez V, Cabrera A, Càrdenas M, Villa S: Stress, immunology and cancer: Effect of psychoactive drugs. Arch Ven Farmac Terap 6:28?43, 1987
- Rubin RT, Poland RE, Hays SE: Psychoneuroendocrine research in endogenous depression: A review.In Biological Psychiatry Today. J Obiols, C Ballus, E Gonzàlez-Monclus, J Pujol (eds). Amsterdam, Elsevier Science Publishers, 1979, pp 684?688
Cited by
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578
Matt, S. M., & Gaskill, P. J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 287
Increased Levels of Free Serotonin in Plasma of Symptomatic Asthmatic Patients
Lechín, F., van der Dijs, B., Orozco, B., Lechin, M. E., & Lechin, A. E. (1996) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63263-2 · Cited by 135
Self-citationLechín, F., van der Dijs, B., Orozco, B., Lechin, M. E., Báez, S., Lechin, A. E., Rada, I., Acosta, E., Arocha, L., Jiménez, V., et al. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00258-5 · Cited by 107
Self-citationImpact of medical comorbid disease on antidepressant treatment of major depressive disorder
Iosifescu, D. V., Bankier, B., & D, M. F. M. (2004) · Current Psychiatry Reports · doi:10.1007/s11920-004-0064-2 · Cited by 65
Metadata
- Authors
- Lechin, F., van der Dijs, B., Rada, I., Jara, H., Lechin, A. E., Cabrera, A., Lechin, M. E., Jimènez, V., Gòmez, F., Villa, S., Acosta, E., & Arocha, L.
- Affiliations
- Universidad Central de Venezuela (VE)
- Venue
- Digestive Diseases and Sciences
- Published
- 1990-11
- Volume
- 35
- Issue
- 11
- Pages
- 1313-1319
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2329891132
- Cited by
- 35
- References
- 39
- Citations by year
- 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- duodenal ulcer, cortisol, norepinephrine, epinephrine, dopamine, platelet serotonin, ulcer recurrence, autonomic imbalance, stress, ulcer healing
- MeSH terms
- Adult, Clonidine, Dopamine, Duodenal Ulcer, Epinephrine, Female, Humans, Hydrocortisone, Male, Middle Aged, Norepinephrine, Psychiatric Status Rating Scales, Recurrence, Serotonin, Stress, Physiological, Wound Healing, Neurotransmitter Agents
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- Lechin, F., van der Dijs, B., Rada, I., Jara, H., Lechin, A. E., Cabrera, A., Lechin, M. E., Jimènez, V., Gòmez, F., Villa, S., Acosta, E., & Arocha, L. (1990). Plasma neurotransmitters and cortisol in duodenal ulcer patients: Role of stress. Digestive Diseases and Sciences. https://doi.org/10.1007/bf01536734
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
